DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and Anpep

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_112274.1	Gene:	Anpep / 81641	RGDID:	2991	Length:	965	Species:	Rattus norvegicus

Alignment Length:	1032	Identity:	350/1032 - (33%)
Similarity:	540/1032 - (52%)	Gaps:	128/1032 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TAKLVAIGLGLALTAFTVSTIVLAVQKANLKSDLRDAQEKLDLLEAGYTSTAAPTTASTANPGST 68
            |..::.|.||:|.....::..|:..|:.|     |:|:          .|..|||.
  Rat    10 TLGILGILLGVAAVCTIIALSVVYAQEKN-----RNAE----------NSAIAPTL--------- 50

  Fly    69 ASPGSTAEPGSTAEPGSTAEPGSTASPGSTVTPGSTASTSEPGTTASPEKIDYRLPGTLKPTHYD 133
                                ||||:         :|.||:.|....|.....||||.||.|..|.
  Rat    51 --------------------PGSTS---------ATTSTTNPAIDESKPWNQYRLPKTLIPDSYQ 86

  Fly   134 L----YLFPNIETG--EFSGQETITITVEEATDQIVLHSLNLNISS-----VSIMNTGS------ 181
            :    ||.|| |.|  .|.|..|:..|..|.|:.|::||..||.::     |::...|.
  Rat    87 VTLRPYLTPN-EQGLYIFKGSSTVRFTCNETTNVIIIHSKKLNYTNKGNHRVALRALGDTPAPNI 150

  Fly   182 DTLEILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDETRKWIAT 246
            ||.|::|.|     |:|:..|...|.||....:...|:|.:|:.:.|.|.|.|: |...:|.:||
  Rat   151 DTTELVERT-----EYLVVHLQGSLVKGHQYEMDSEFQGELADDLAGFYRSEYM-EGGNKKVVAT 209

  Fly   247 SKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNM-NVDSSVSQ--GAFQEVTFAKSV 308
            ::.:...||::||||||||:||.|.|||:||:  :..||||| ..||...|  .::....|..:.
  Rat   210 TQMQAADARKSFPCFDEPAMKASFNITLIHPN--NLTALSNMLPKDSRTLQEDPSWNVTEFHPTP 272

  Fly   309 PMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLDK--VDLAVTIGKGVIEYYIDYFQ 371
            .|||||..:|||:|.|.:.....:     ..:.::|.|..:|:  .|.|:.:...::.::..::.
  Rat   273 KMSTYLLAYIVSEFKYVEAVSPNR-----VQIRIWARPSAIDEGHGDYALQVTGPILNFFAQHYN 332

  Fly   372 IAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNL 436
            .||||.|.|..|:|||.:||||:||||||||::|::|..:||.:||:|:.:|||||.||.|||||
  Rat   333 TAYPLEKSDQIALPDFNAGAMENWGLVTYRESALVFDPQSSSISNKERVVTVIAHELAHQWFGNL 397

  Fly   437 VTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPI---IQTVE 498
            ||::|||||||||||||:||:||.|...|.|.::|...::.::.|:.:|....|||:   ...|.
  Rat   398 VTVDWWNDLWLNEGFASYVEFLGADYAEPTWNLKDLIVLNDVYRVMAVDALASSHPLSSPANEVN 462

  Fly   499 NPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTEIDK----- 558
            .|.||:|:||:||||||:|::|||..||.|..|::.:::||:.::||.....:.:..:.:
  Rat   463 TPAQISELFDSITYSKGASVLRMLSSFLTEDLFKKGLSSYLHTFQYSNTIYLDLWEHLQQAVDSQ 527

  Fly   559 --LELGYNVTEIMLTWTVQMGLPVVTIEKVSDTEYKLTQKRFLSNPNDYDADHEPSEFNYRWSIP 621
              ::|..:|:.||..|.:|||.||:|:...:...|   |:.||.:|.....  .||:|||.|.:|
  Rat   528 TAIKLPASVSTIMDRWILQMGFPVITVNTSTGEIY---QEHFLLDPTSKPT--RPSDFNYLWIVP 587

  Fly   622 ITYFTSSDSVVQRLWFYHDQSEITVTVPAAVEWIKFNADQVGYYRVNYDTDLWNDLADQLVVQPS 686
            |.|..:...  ...|...::::......::.||:..|.:..|||:||||.:.|..:.:||....|
  Rat   588 IPYLKNGKE--DHYWLETEKNQSAEFQTSSNEWLLLNINVTGYYQVNYDENNWRKIQNQLQTDLS 650

  Fly   687 AFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAASRLTSLKRTLYYTSTYA 751
            ....::||.:::|:|.||.:.:|........|.:|..||:|:||..|.|.|...|.....:..|.
  Rat   651 VIPVINRAQIIHDSFNLASAGKLSITLPLSNTLFLASETEYMPWEAALSSLNYFKLMFDRSEVYG 715

  Fly   752 KYKKYATALIEPIYTAL-----TW-----TVGEDHLDNRLRVTALSAACSLGLESCLTEAGEQFN 806
            ..|:|....:.|::...     .|     |:.|.:.:    :.|:|.|||.|||.|.......::
  Rat   716 PMKRYLKKQVTPLFAYFKIKTNNWLDRPPTLMEQYNE----INAISTACSSGLEECRDLVVGLYS 776

  Fly   807 AWLAKPEDRP-KADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLMYGLSAIQIPWIL 870
            .|:...::.| ..::|.|||...| :.|.:|:|:..||.|...:..:|..||...|:.....|||
  Rat   777 QWMNNSDNNPIHPNLRSTVYCNAI-AFGGEEEWNFAWEQFRKATLVNEADKLRSALACSNEVWIL 840

  Fly   871 QRYIDLAWNEEYVRGQDYFTCLTYISANPVGESLVWDYVRENWQRLVDRFGLNERYLGNLIPSIT 935
            .||:....|.:|:|.||..:.:..|:.|.||::||||:||.||::|.:.:|.......|||..:|
  Rat   841 NRYLSYTLNPDYIRKQDATSTIVSIANNVVGQTLVWDFVRSNWKKLFEDYGGGSFSFANLIQGVT 905

  Fly   936 ARFSTQTKLEEMEQFFAKYPEA----GAGTAARVRALETVKNNIVWLAENLEGVDAW 988
            .|||::.:|:::|||  |...:    |:||.|..:|||..|.||.|:.||.:.|..|
  Rat   906 RRFSSEFELQQLEQF--KEDNSATGFGSGTRALEQALEKTKANIKWVKENKDVVLKW 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	170/417 (41%)
		M1_APN_2	130..579	CDD:189008	186/480 (39%)
		ERAP1_C	655..969	CDD:288671	104/328 (32%)
Anpep	NP_112274.1	Cytosolic Ser/Thr-rich junction	33..68		16/87 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..68		12/61 (20%)
		Metalloprotease	69..965		327/920 (36%)
		Peptidase_M1	75..479	CDD:279741	170/417 (41%)
		M1_APN_2	84..550	CDD:189008	186/479 (39%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	351..355		3/3 (100%)
		ERAP1_C	619..942	CDD:288671	105/329 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.820