DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8773 and Erap1

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_109636.1	Gene:	Erap1 / 80898	MGIID:	1933403	Length:	930	Species:	Mus musculus

Alignment Length:	915	Identity:	318/915 - (34%)
Similarity:	487/915 - (53%)	Gaps:	75/915 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 RLPGTLKPTHYDLYLFPNIETGEFSGQETITITVEEATDQIVLHSLNLNISSVSIMNTGSDTL-- 184
            |||..:.|.||||.:..|:.|..|.|:..:.|.....|..|::||.:|.||..::.....:.|
Mouse    42 RLPEYMTPIHYDLMIHANLSTLTFWGKTEVEIIASRPTSTIIMHSHHLQISKATLRRGAGEMLSE 106

  Fly   185 EILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDETRKWIATSKF 249
            |.|:.......|.:.....:||..|....:.|.:..:::....|.|.|:|..::...:.:|.::|
Mouse   107 EPLKVLEYPAHEQVALLAAQPLLAGSLYTVIIDYAANLSESFHGFYKSTYRTQEGEMRILAATQF 171

  Fly   250 EPTYARQAFPCFDEPALKAEFTITLVHPSGEDYH-ALSNMNVDSS--VSQGAFQEVTFAKSVPMS 311
            |||.||.||||||||||||.|:|.:   ..:..| |:|||.:..|  |::|..:: .|..:|.||
Mouse   172 EPTAARMAFPCFDEPALKASFSIKI---KRDPRHLAISNMPLVKSVNVAEGLIED-HFDITVKMS 232

  Fly   312 TYLACFIVSDFAYKQVSIDTK-GIGETFSMSVYATPEQLDKVDLAVTIGKGVIEYYIDYFQIAYP 375
            |||..||:|||  |.||..|| |:    .:||||.|:::::.|.|:.....::|:|.|||.|.||
Mouse   233 TYLVAFIISDF--KSVSKMTKSGV----KVSVYAVPDKINQADYALDAAVTLLEFYEDYFNIPYP 291

  Fly   376 LPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMN 440
            |||.|:||||||.|||||:|||.||||:|||||:..|||::|..|..:::||.||.||||||||.
Mouse   292 LPKQDLAAIPDFQSGAMENWGLTTYRESSLLYDKEKSSASSKLGITMIVSHELAHQWFGNLVTME 356

  Fly   441 WWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPIIQTVENPDQITE 505
            ||||||||||||.|:|::.|...:||.|:.|.| .....:.:.:|....|||:...||||.||.|
Mouse   357 WWNDLWLNEGFAKFMEFVSVTVTHPELKVEDYF-FGKCFNAMEVDALNSSHPVSTPVENPAQIRE 420

  Fly   506 IFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYS------------------------- 545
            :||.::|.||:.::.||.|:|...||::.:..||.:|.|.
Mouse   421 MFDDVSYEKGACILNMLRDYLSADTFKRGIVQYLQKYSYKNTKNEDLWNSMMHICPTDGTQTMDG 485

  Fly   546 -------TAETGNFFTEIDKLELGYNVTEIMLTWTVQMGLPVVTIEKVSDTEYKLTQKRFLSNPN 603
                   ::.|.::..|:      .:|..:|.|||:|.|.|::|| .||.....:.|:.::....
Mouse   486 FCSRSQHSSSTSHWRQEV------VDVKTMMNTWTLQKGFPLITI-TVSGRNVHMKQEHYMKGSE 543

  Fly   604 DYDADHEPSEFNYRWSIPITYFTSSDSVVQRLWFYHDQSEITVTVPAAVEWIKFNADQVGYYRVN 668
            .:      .|..|.|.:|:|:.||....||| :....::::.: :|.||:|||||....|||.|:
Mouse   544 RF------PETGYLWHVPLTFITSKSDSVQR-FLLKTKTDVLI-LPEAVQWIKFNVGMNGYYIVH 600

  Fly   669 YDTDLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVA 733
            |..|.|..|:..|....:...|.|||.|:|:||.|....:|....|.:||.||..||:.:|...|
Mouse   601 YADDGWASLSGLLKEAHTTISSNDRASLINNAFQLVSIEKLSIEKALDLTLYLKNETEIMPIFQA 665

  Fly   734 ASRLTSL-----KRTLYYTSTYAKYKKYATALIEPIYTALTWTVGEDHLDNRLRVTALSAACSLG 793
            .:.|..:     ||.:....|  ::|.:...|::.:....|||......:..||...|..||...
Mouse   666 LNELIPMYKLMEKRDMIEVET--QFKDFLLKLLKDLIDKQTWTDEGSVSERMLRSQLLLLACVRN 728

  Fly   794 LESCLTEAGEQFNAWLAKPEDRP-KADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKL 857
            .:.|:..|...|..|.:...:.. ..||...|:..|.|:.   |.||.::..:.:...::|||::
Mouse   729 YQPCVQRAERYFREWKSSNGNMSIPIDVTLAVFAVGAQNT---EGWDFLYSKYQSSLSSTEKSQI 790

  Fly   858 MYGLSAIQIPWILQRYIDLAWNEEYVRGQDYFTCLTYISANPVGESLVWDYVRENWQRLVDRFGL 922
            .:.|...:.|..||..:|.::..|.::.|::...||.|..||||..|.|.::||||.:||.:|.|
Mouse   791 EFSLCTSKDPEKLQWLLDQSFKGEIIKTQEFPHILTLIGRNPVGYPLAWKFLRENWNKLVQKFEL 855

  Fly   923 NERYLGNLIPSITARFSTQTKLEEMEQFFAKYPEAGAGTAARVRALETVKNNIVWLAENLEGVDA 987
            ....:.:::...|.:|||:.:|||::.||:...|.|:......:.:||::.||.|:.:|.:.:..
Mouse   856 GSSSIAHMVMGTTDQFSTRARLEEVKGFFSSLKENGSQLRCVQQTIETIEENIRWMDKNFDKIRL 920

  Fly   988 WLDKQ 992
            ||.|:
Mouse   921 WLQKE 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	172/398 (43%)
		M1_APN_2	130..579	CDD:189008	189/486 (39%)
		ERAP1_C	655..969	CDD:288671	96/319 (30%)
Erap1	NP_109636.1	M1_APN-Q_like	50..515	CDD:341064	186/481 (39%)
		Substrate binding. /evidence=ECO:0000250	306..310		3/3 (100%)
		ERAP1_C	586..905	CDD:403137	99/323 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1883
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.770