DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8773 and Aopep

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_001276853.1	Gene:	Aopep / 72061	MGIID:	1919311	Length:	823	Species:	Mus musculus

Alignment Length:	725	Identity:	133/725 - (18%)
Similarity:	231/725 - (31%)	Gaps:	265/725 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 PGSTASTSEPGTTASPEKID-------YRLPGTLKPTHYDLYLFPNIETGEFSGQETITITVEEA 158
            ||....|..|...|:|||:.       ..||........|.|...:...|
Mouse   165 PGLEKFTKAPKLLATPEKLRCEIVRDLVALPADAWREQLDCYTRCSQAPG--------------- 214

  Fly   159 TDQIVLHSLNLNISSVSIMNTGSDTLEILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSMA 223
            ..::::.|.|.   |:.|..||:      .|..|..|...|:...:|             ||.
Mouse   215 CGELLIDSDNW---SLRIRKTGT------STPADFPRAIRIWYKTKP-------------EGQ-- 255

  Fly   224 NKIVGLYSSSYVKEDETRKWIATSKFEPTYARQAFPCFDEPALKAEFTIT-------LVHPSGED 281
                   |.::..:...|..:.|.. .|...|..|||.:.|...:.:..|       :|..|||
Mouse   256 -------SVAWTTDQNGRPCVYTMG-SPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGE- 311

  Fly   282 YHALSNMNVDSSVSQGAFQEVTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATP 346
                 |....:.:.:| :....:..::||.       .|.||.        .:|....|...|:|
Mouse   312 -----NSAKPTPLREG-YMSWHYYVTMPMP-------ASTFAI--------AVGCWTEMKPKASP 355

  Fly   347 --EQLDKVDLAVTIGKGVIEY-----YIDY---FQIA---------------------------- 373
              :.:.:..|.::..:..:.|     :::|   ||.|
Mouse   356 PDDLMTEHSLPLSPSEADLRYDNTCNHMEYPCRFQSASAASQDIIPYRVFAPVCLEGACQEALLW 420

  Fly   374 ---------------YPLPKLDMAAIP-DFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIAS 422
                           :|..:||:..:| :|.|..|....::...:::|   ..||.....:
Mouse   421 LIPSCLSAAHSVLGTHPFSRLDILIVPTNFPSLGMASPHIIFLSQSTL---TGTSHLCGTR---- 478

  Fly   423 VIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPE--------------------W 467
             :.||.||.|||..:....|.:.||:||||:.:|    |..:.|                    |
Mouse   479 -LCHEIAHSWFGLAIGARDWTEEWLSEGFATHLE----DIFWAEAQQLPPHEALEQQELRACLRW 538

  Fly   468 -KMRDQFTVS-------------TLHSVLTLDGTLGSHPIIQTVENPDQITEIFDTITYSKGSSL 518
             :::|:...|             |.| |.....::..|.:     ||:   :.|..:.|.||..|
Mouse   539 HRLQDELRNSPEGMQVLRPNKEETGH-VSASGASVVKHGL-----NPE---KGFMQVHYLKGYFL 594

  Fly   519 VRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTEI-----DKLELGYNVTEIMLTWTVQMGL 578
            :|.|...|||..:...:..:::.:......:.:|...:     :...||.:|..|:..|....|:
Mouse   595 LRFLTRTLGEKIYFPFLRKFVHLFHGQLILSQDFLQMLLENIPENKRLGLSVENIVRDWLECSGI 659

  Fly   579 P-------------------------------------------VVTIEKVSD------TEYKLT 594
            |                                           .|..||:|.      .|:.|.
Mouse   660 PKALQEERKAEDCSPSRLARQVGSEVAKWIRVNRRPRKRKRGKREVAFEKLSPDQIVLLLEWLLE 724

  Fly   595 QKRFLSNP-------NDYDADHEPSEFNYRW-SIPITY-FTSSDSVVQRLWFYHDQS-------E 643
            ||..  :|       ..|....:.:|..:|| .:.|.: :|.:.:.|:| :...||:       |
Mouse   725 QKTL--SPQTLHCLQQTYHLPEQDAEVRHRWCELVIKHKYTKAYNQVER-FLLEDQAMGIYLYGE 786

  Fly   644 ITVTVPAAVE 653
            :.|:..|.::
Mouse   787 LMVSEDARLQ 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	87/487 (18%)
		M1_APN_2	130..579	CDD:189008	100/548 (18%)
		ERAP1_C	655..969	CDD:288671
Aopep	NP_001276853.1	GluZincin	186..634	CDD:301352	96/537 (18%)
		Leuk-A4-hydro_C	680..821	CDD:286244	22/120 (18%)
		Nucleolar localization signal. /evidence=ECO:0000269\|PubMed:17803194	693..703		0/9 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810