Protein Alignment CG8773 and RNPEP

DIOPT Version :9

• Sequence 1: NP_650273.2
• Gene: CG8773 / 41634
• FlyBaseID: FBgn0038135
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_064601.3
• Gene: RNPEP / 6051
• HGNCID: 10078
• Length: 650
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 114/514 - (22%)
• Similarity: 181/514 - (35%)
• Gaps: 148/514 - (28%)

  Fly   255 RQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNVDSSVSQGAFQEVTFAKSVPMSTYLACFIV 319
            |..|||||.||:|.:::..:..|.|  :.|:  |:..:...:|. .:..|....|:.:||....:
Human   176 RAFFPCFDTPAVKYKYSALIEVPDG--FTAV--MSASTWEKRGP-NKFFFQMCQPIPSYLIALAI 235

  Fly   320 SDFAYKQVSIDTKGIGETFSMSVYATPEQLDKVDLAVTIGKGVIEYYI--------DYFQIAYPL 376
            .|....:|...::         |:|.|   ..:|.|.....||||.::        .|....|.|
Human   236 GDLVSAEVGPRSR---------VWAEP---CLIDAAKEEYNGVIEEFLATGEKLFGPYVWGRYDL 288

  Fly   377 PKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMNW 441
                :...|.|..|.||: ..:|:....||        ...:.:|.||.||.:|.|||||||...
Human   289 ----LFMPPSFPFGGMEN-PCLTFVTPCLL--------AGDRSLADVIIHEISHSWFGNLVTNAN 340

  Fly   442 WNDLWLNEGFASFVE-----------YLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPI-- 493
            |.:.||||||..:.:           |..::|......:|..           :|.|...:|:
Human   341 WGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQH-----------MDITGEENPLNK 394

  Fly   494 ----IQTVENPDQITEIFDTITYSKGSSLVRMLEDFLG-ETTFRQAVTNYLNEYKYSTAETGNF- 552
                |:...:||   :.::...|.||...|..|...:| :..|...:..|::|:|:.:....:|
Human   395 LRVKIEPGVDPD---DTYNETPYEKGFCFVSYLAHLVGDQDQFDSFLKAYVHEFKFRSILADDFL 456

  Fly   553 ------FTEIDKLEL----GYN--------------------------VTEIMLTWTVQMGLPVV 581
                  |.|:.|..:    |:.                          ..|:...|..: .|.:.
Human   457 DFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEELAQLWAAE-ELDMK 520

  Fly   582 TIEKVSDTEY----------KLTQKRFLSNPNDYD-ADHEPS-------EFNYRWSIPITYFTSS 628
            .||.|:.:.:          |:.||..|...|... .|..||       |...||.    .....
Human   521 AIEAVAISPWKTYQLVYFLDKILQKSPLPPGNVKKLGDTYPSISNARNAELRLRWG----QIVLK 581

  Fly   629 DSVVQRLW----FYHDQSEITVTVP--------------AAVEWIKFNADQVGYYRVNY 669
            :...:..|    |.|:|.:...|:|              .|.|.....|.|:....|||
Human   582 NDHQEDFWKVKEFLHNQGKQKYTLPLYHAMMGGSEVAQTLAKETFASTASQLHSNVVNY 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	70/284 (25%)
		M1_APN_2	130..579	CDD:189008	86/386 (22%)
		ERAP1_C	655..969	CDD:288671	5/15 (33%)
RNPEP	NP_064601.3	leuko_A4_hydro	24..634	CDD:274120	111/506 (22%)
		M1_LTA4H	24..484	CDD:189006	84/351 (24%)
		Substrate binding. /evidence=ECO:0000250	298..302		2/3 (67%)
		Leuk-A4-hydro_C	504..644	CDD:286244	30/142 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810