Protein Alignment CG8773 and RNPEPL1

DIOPT Version :9

• Sequence 1: NP_650273.2
• Gene: CG8773 / 41634
• FlyBaseID: FBgn0038135
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_060696.4
• Gene: RNPEPL1 / 57140
• HGNCID: 10079
• Length: 725
• Species: Homo sapiens
• Alignment Length: 831
• Identity: 161/831 - (19%)
• Similarity: 271/831 - (32%)
• Gaps: 253/831 - (30%)

  Fly    39 DAQEKLDLLEAGYTSTAAPTTASTANPGSTASPGSTAEPGSTAEPGSTAEPGSTASPGSTVTPGS 103
            ||...|.|..|.:....| ..|.|....:.::||          ||....|...|.|.:   ||
Human    78 DAHPALRLHSAAFRRAPA-AAAETPCAFAFSAPG----------PGPAPPPPLPAFPEA---PG- 127

  Fly   104 TASTSEPGTTASPEKIDYRLPGTLKPTHYDLYLFPNIETGEFSGQETITITVE---EATDQIVLH 165
                |||.......::|   |.|                 ::....|:|:..|   ....|::|.
Human   128 ----SEPACCPLAFRVD---PFT-----------------DYGSSLTVTLPPELQAHQPFQVILR 168

  Fly   166 SLNLNISSVSIMNTGSDTLEILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLY 230
            ..:.:..::..::.        |.|....:.|:       .|:|.          |:.|
Human   169 YTSTDAPAIWWLDP--------ELTYGCAKPFV-------FTQGH----------SVCN------ 202

  Fly   231 SSSYVKEDETRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNVDSSVS 295
                                    |..|||||.||:|..::..:..|||        :.|..|.:
Human   203 ------------------------RSFFPCFDTPAVKCTYSAVVKAPSG--------VQVLMSAT 235

  Fly   296 QGAFQE----VTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLDKVDLAV 356
            :.|:.|    ..|....|:..||...:..|.  |...|..:.       .|:|.|..|   ..|.
Human   236 RSAYMEEEGVFHFHMEHPVPAYLVALVAGDL--KPADIGPRS-------RVWAEPCLL---PTAT 288

  Fly   357 TIGKGVIEYYIDYFQIAY-PL--PKLDMAAI-PDFVSGAMEHWGLVTYRETSLLYDEATSSATNK 417
            :...|.:|.::...:..| |.  .:.|:..: |.|...|||: ..:|:..:|:|..:
Human   289 SKLSGAVEQWLSAAERLYGPYMWGRYDIVFLPPSFPIVAMEN-PCLTFIISSILESD-------- 344

  Fly   418 QRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPE--WKMRDQFTVSTLHS 480
            :.:...:.||.||.||||.||...|.::||:||.|::.:.......|..  ..:...|.:..||.
Human   345 EFLVIDVIHEVAHSWFGNAVTNATWEEMWLSEGLATYAQRRITTETYGAAFTCLETAFRLDALHR 409

  Fly   481 VLTLDGTLGSHPIIQTVE-------NPDQITEIFDTITYSKGSSLVRMLEDFLGE-TTFRQAVTN 537
            .:.|   ||....:..::       ||..:..:|   ||.||...|..|....|: ..|...:..
Human   410 QMKL---LGEDSPVSKLQVKLEPGVNPSHLMNLF---TYEKGYCFVYYLSQLCGDPQRFDDFLRA 468

  Fly   538 YLNEYKYSTAETG-------NFFTEIDKLELGYNVTEIMLTWTVQMGLPVVTIEKVSDTEYKLTQ 595
            |:.:||:::....       :||.|:.:..:..........|....|.|:        .|..|:|
Human   469 YVEKYKFTSVVAQDLLDSFLSFFPELKEQSVDCRAGLEFERWLNATGPPL--------AEPDLSQ 525

  Fly   596 KRFLSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVVQRLWFYH--DQSEITVTVPAAVEWIKFN 658
            ...|:.|.:                          .:.:||...  ||:..:.:.....:|..|
Human   526 GSSLTRPVE--------------------------ALFQLWTAEPLDQAAASASAIDISKWRTF- 563

  Fly   659 ADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDK 723
                                     |.:.|  :||         |.|.:.||......|::....
Human   564 -------------------------QTALF--LDR---------LLDGSPLPQEVVMSLSKCYSS 592

  Fly   724 ETDYVPWSVAASRLTSLKRTLYYTSTYAKYKKYATALIEPIYTALTW------------------ 770
            ..|.:...:....|..:.|..||...: :.:::..:.:..:||...:
Human   593 LLDSMNAEIRIRWLQIVVRNDYYPDLH-RVRRFLESQMSRMYTIPLYEDLCTGALKSFALEVFYQ 656

  Fly   771 TVGEDHLDNRLRVTALSAACSLGLESCLTEAGEQFNAWLAKPEDRPKADVR 821
            |.|..|.:.|   .|:....|.||.|. ||...:.:..|.|.|....:|.:
Human   657 TQGRLHPNLR---RAIQQILSQGLGSS-TEPASEPSTELGKAEADTDSDAQ 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	83/412 (20%)
		M1_APN_2	130..579	CDD:189008	95/476 (20%)
		ERAP1_C	655..969	CDD:288671	32/185 (17%)
RNPEPL1	NP_060696.4	M1_LTA4H	29..512	CDD:341062	117/562 (21%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P15144	326..330		2/3 (67%)
		Leuk-A4-hydro_C	560..673	CDD:401171	23/153 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..699		8/23 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810