DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8773 and trhde.2

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	XP_690889.2	Gene:	trhde.2 / 562409	ZFINID:	ZDB-GENE-070705-89	Length:	994	Species:	Danio rerio

Alignment Length:	1025	Identity:	316/1025 - (30%)
Similarity:	504/1025 - (49%)	Gaps:	98/1025 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 IVTAKLVAIGLGLA-LTAFTVSTIVLAVQKANLKSDLRDAQEKLDLLEAGYTSTAAPTTASTANP 65
            |...|.:.:|..:: ||...|:.|.:.                   |...:...||.::.:.|..
Zfish    33 ITVHKRLVLGFAISILTLIIVTAIAIT-------------------LSVSFERCAAESSGALAAN 78

  Fly    66 GSTASPGSTAEPGSTAEPGSTAEPGSTASPGSTVTPGSTASTSEPGTTASPEKIDYRLPGTLKPT 130
            ||:.|....:..|:.:.                       ..||.|  ..|.: ..|||.||:|.
Zfish    79 GSSNSKWKQSRDGNISH-----------------------RDSEDG--QQPWR-HLRLPATLRPR 117

  Fly   131 HYDLYLFPNIETGEFSGQETITITVEEATDQIVLHSLNLNISSVSIMNTG--SDTLEILETTVDA 193
            ||||.|..::|...|||:..|......:|..|||||..|.:..|.:.:..  :..:.|.......
Zfish   118 HYDLRLTVHMENFSFSGEVNIEFECVNSTKLIVLHSDRLELDKVLVFSDSKKAGAMRIQRRFHYQ 182

  Fly   194 VREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDETRKWIATSKFEPTYARQAF 258
            .::..:..|:..:...||.:::|.|...:.::::|.:.|||:...| |:::|.::|.||:||:||
Zfish   183 PKQVYVIALHREMKPLRTYKINITFTAHIEHELLGFFRSSYMLNGE-RRFLAVTQFSPTHARKAF 246

  Fly   259 PCFDEPALKAEFTITLVHPSGEDYHALSNMNVDSSVS-QGAFQEVTFAKSVPMSTYLACFIVSDF 322
            ||||||..||.|.::|.|.|  .|.:||||.|:::.| :..:....|:::..||||...:.|.:|
Zfish   247 PCFDEPIYKATFRVSLKHES--SYQSLSNMPVEATTSDEDGWVTNHFSRTPRMSTYYLAWAVCNF 309

  Fly   323 AYKQVSIDTKGIGETFSMSVYATPE--QLDKVDLAVTIGKGVIEYYIDYFQIAYPLPKLDMAAIP 385
            .||:...| .|:    .:.:||.|:  |....|.|:.|.|.::::|.|||::.|.|||||:.|:|
Zfish   310 TYKEAVAD-NGV----LIRLYARPDAIQSGSGDYALRITKRLLQFYQDYFKVKYSLPKLDLLAVP 369

  Fly   386 DFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEG 450
            .....|||:|||..:.|..:|.|...||.:.:..:..|:.||..|.|||:|||..||.|:||.||
Zfish   370 KHPYAAMENWGLSVFVEQKILLDPDVSSFSYQMELTMVVVHEICHQWFGDLVTPVWWEDVWLKEG 434

  Fly   451 FASFVEYLGVDAVYPEWKMRDQ-FTVSTLHSVLTLDGTLGSHPIIQTVENPDQITEIFDTITYSK 514
            ||.:.||:|.|.::|:|.|..| |....||.|:.|||...||||.|.|.....|..:||.|.|.|
Zfish   435 FAHYFEYIGTDFLFPKWNMEKQRFLTDVLHEVMLLDGLASSHPISQQVFEATDIDRVFDWIAYKK 499

  Fly   515 GSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTEIDKL----ELGYNVTEIMLTWTVQ 575
            |::|:|||.:.:|:|.|::|:.:||..:.|..|...:.:.::.:.    ....|:|::|..||:|
Zfish   500 GAALIRMLANVMGQTLFQRALNDYLMTHMYGNAARDDLWNKLSEAMQREGKDINITQVMDRWTLQ 564

  Fly   576 MGLPVVTIEKVS--DTEYKLTQKRFLSNPNDYDAD---HEPSEFN--YRWSIPITYFTSSDSVVQ 633
            ||.|||||.|..  |....::|:.|:     ||.|   ..|..||  ::|.||:|....:.|.:.
Zfish   565 MGYPVVTISKNDSLDNSITISQEHFV-----YDTDAKIQNPELFNKSFQWQIPLTLAVGNASHIS 624

  Fly   634 R---LWFYHDQSEITVTVPAAVEWIKFNADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAH 695
            .   :|..:......|.......|:..|.:|.||:|||||...|..|..||...|:.....:||.
Zfish   625 TETIIWVTNKSEAHRVGHVVGETWLLGNINQTGYFRVNYDLHNWKLLIQQLTRNPTIISVGNRAG 689

  Fly   696 LLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAASRLTSLKRTLYYTSTYAKYKKYATAL 760
            |::|.|.||.:..||.....::..||.:||:::||..|:..|..|.:.|..|..::.:..|....
Zfish   690 LIDDVFNLARAGYLPQNVPLQMISYLSQETEFLPWHAASRALYQLDKLLDRTLDHSLFSDYVLRQ 754

  Fly   761 IEPIYTALTW--------TVGEDHLDNRLRVTALSAACSLGLESCLTEAGEQFNAWLAKPEDRPK 817
            :||.|..|.|        .:...:....|:...:..|||.|.:.|..:|....:.|::..::|..
Zfish   755 VEPKYHKLGWPATSPDGSLMHSAYQTEELQREVIMLACSFGNKHCHRQAVSLISDWISSNKNRIP 819

  Fly   818 ADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLMYGLSAIQIPWILQRYIDLAWNEEY 882
            .:||:.||..|: |:..::.|:.:|..|.:.:..|||..|:..|:.....::|.|.::|:...:.
Zfish   820 PNVRDIVYCTGV-SLMDEDVWEFIWMKFHSSTAVSEKKVLLEALTCSDNIFLLNRLLNLSLTSDL 883

  Fly   883 VRGQDYFTCLTYISANPVGESLVWDYVRENWQRLVDRFG----LNERYLGNLIPSITARFSTQTK 943
            |..||....:.:::.||:|..|.|.|.||.|..|..|:|    :|.:    ||..:|...:|:.:
Zfish   884 VPDQDVIDVIIHVARNPLGRHLAWRYFREKWDILNSRYGEALFMNSK----LISGVTEFLNTEAE 944

  Fly   944 LEEMEQFFAKYPEAGAGTAARVRALETVKNNIVWLAENLEGVDAWLDKQP 993
            |.|:::|.  ....|....|..||:|.|:.|:.|.....|....||.|.|
Zfish   945 LNELKEFI--LTSGGESAPAFARAVEIVQANVKWHILFQEQFYQWLRKAP 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	150/398 (38%)
		M1_APN_2	130..579	CDD:189008	166/458 (36%)
		ERAP1_C	655..969	CDD:288671	93/325 (29%)
trhde.2	XP_690889.2	Peptidase_M1	109..500	CDD:279741	150/398 (38%)
		M1_APN_2	118..568	CDD:189008	166/457 (36%)
		ERAP1_C	649..968	CDD:288671	93/325 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010