DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8773 and ERAP1

DIOPT Version :9

Sequence 1:NP_650273.2 Gene:CG8773 / 41634 FlyBaseID:FBgn0038135 Length:994 Species:Drosophila melanogaster
Sequence 2:XP_005272072.1 Gene:ERAP1 / 51752 HGNCID:18173 Length:951 Species:Homo sapiens


Alignment Length:945 Identity:328/945 - (34%)
Similarity:496/945 - (52%) Gaps:85/945 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 TASTSE--PGTTASPEKID--------YRLPGTLKPTHYDLYLFPNIETGEFSGQETITITVEEA 158
            |.||..  ..|.|||::.|        .|||..:.|.||||.:..|:.|..|.|...:.||..:.
Human    25 TVSTPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQP 89

  Fly   159 TDQIVLHSLNLNISSVSIMNTGSDTL--EILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGS 221
            |..|:|||.:|.||..::.....:.|  |.|:......:|.:.....|||..|....:.|.:.|:
Human    90 TSTIILHSHHLQISRATLRKGAGERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGN 154

  Fly   222 MANKIVGLYSSSY-VKEDETRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYH-A 284
            ::....|.|.|:| .||.|.| .:|:::||||.||.|||||||||.||.|:|.:   ..|..| |
Human   155 LSETFHGFYKSTYRTKEGELR-ILASTQFEPTAARMAFPCFDEPAFKASFSIKI---RREPRHLA 215

  Fly   285 LSNMNVDSS--VSQGAFQEVTFAKSVPMSTYLACFIVSDFAYKQVSIDTK-GIGETFSMSVYATP 346
            :|||.:..|  |::|..:: .|..:|.|||||..||:|||  :.||..|| |:    .:||||.|
Human   216 ISNMPLVKSVTVAEGLIED-HFDVTVKMSTYLVAFIISDF--ESVSKITKSGV----KVSVYAVP 273

  Fly   347 EQLDKVDLAVTIGKGVIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEAT 411
            :::::.|.|:.....::|:|.|||.|.|||||.|:||||||.|||||:|||.||||::||:|...
Human   274 DKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEK 338

  Fly   412 SSATNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVS 476
            |||::|..|...:|||.||.||||||||.||||||||||||.|:|::.|...:||.|:.|.| ..
Human   339 SSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYF-FG 402

  Fly   477 TLHSVLTLDGTLGSHPIIQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNE 541
            .....:.:|....|||:...||||.||.|:||.::|.||:.::.||.::|....|:..:..||.:
Human   403 KCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQK 467

  Fly   542 YKYSTAETGNFFTEIDKL--------------------------ELGYNVTEIMLTWTVQMGLPV 580
            :.|...:..:.:..:..:                          :.|.:|..:|.|||:|.|.|:
Human   468 HSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPL 532

  Fly   581 VTIEKVSDTEYKLTQKRFLSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVVQRLWFYHDQSEIT 645
            :|| .|......:.|:.::..     :|..| :..|.|.:|:|:.||...:|.| :....::::.
Human   533 ITI-TVRGRNVHMKQEHYMKG-----SDGAP-DTGYLWHVPLTFITSKSDMVHR-FLLKTKTDVL 589

  Fly   646 VTVPAAVEWIKFNADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLP 710
            : :|..|||||||....|||.|:|:.|.|:.|...|....:|..|.|||.|:|:||.|....:|.
Human   590 I-LPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLS 653

  Fly   711 YATAFELTRYLDKETDYVPWSVAASRLTSL-----KRTLYYTSTYAKYKKYATALIEPIYTALTW 770
            ...|.:|:.||..||:.:|.....:.|..:     ||.:....|  ::|.:...|:..:....||
Human   654 IEKALDLSLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVET--QFKAFLIRLLRDLIDKQTW 716

  Fly   771 TVGEDHLDNRLRVTALSAACSLGLESCLTEAGEQFNAW------LAKPEDRPKADVRETVYYYGI 829
            |......:..||...|..||....:.|:..|...|..|      |:.|     .||...|:..|.
Human   717 TDEGSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLP-----VDVTLAVFAVGA 776

  Fly   830 QSVGSQEDWDAVWELFVNESDASEKSKLMYGLSAIQIPWILQRYIDLAWNEEYVRGQDYFTCLTY 894
            ||.   |.||.::..:.....::|||::.:.|...|....||..:|.::..:.::.|::...||.
Human   777 QST---EGWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTL 838

  Fly   895 ISANPVGESLVWDYVRENWQRLVDRFGLNERYLGNLIPSITARFSTQTKLEEMEQFFAKYPEAGA 959
            |..||||..|.|.::|:||.:||.:|.|....:.:::...|.:|||:|:|||::.||:...|.|:
Human   839 IGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKENGS 903

  Fly   960 GTAARVRALETVKNNIVWLAENLEGVDAWLDKQPL 994
            ......:.:||::.||.|:.:|.:.:..||..:.|
Human   904 QLRCVQQTIETIEENIGWMDKNFDKIRVWLQSEKL 938

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8773NP_650273.2 Peptidase_M1 122..515 CDD:279741 178/399 (45%)
M1_APN_2 130..579 CDD:189008 191/481 (40%)
ERAP1_C 655..969 CDD:288671 97/324 (30%)
ERAP1XP_005272072.1 M1_APN_2 61..531 CDD:189008 191/481 (40%)
ERAP1_C 597..916 CDD:314669 100/328 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1883
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100307
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X67
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.770

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