DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8773 and Npepps

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_536320.1	Gene:	Npepps / 50558	RGDID:	619962	Length:	920	Species:	Rattus norvegicus

Alignment Length:	901	Identity:	297/901 - (32%)
Similarity:	468/901 - (51%)	Gaps:	54/901 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 GTTASPEKIDY-RLPGTLKPTHYDLYLFPNIETGEFSGQETITITVEEATDQIVLHSLNLNISSV 174
            |..|.|||..: |||..:.|.:|.|.|.|::....|.|:......|.:||:|||::..:::|.:.
  Rat    42 GLAAMPEKRPFERLPTEVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITA 106

  Fly   175 SIMNTGSDTLEILETTVDAVREFLIFQLNEPLT-KGRTVRLHIGFEGSMANKIVGLYSSSYVKED 238
            |....|.:  ||..|..:...|.....|:.|.| :..|..|.|.|.|.:.:|:.|.|.|.|....
  Rat   107 SYAPEGDE--EIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSRYTTPA 169

  Fly   239 ETRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNV--------DSSVS 295
            ...::.|.::||.|.||:||||:||||:||.|.|:||.|  :|..|||||||        |.::
  Rat   170 GEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVP--KDRVALSNMNVIDRKPYPDDENL- 231

  Fly   296 QGAFQEVTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLDKVDLAVTIGK 360
                .||.||::..|||||..|:|.::.:    ::|:. .:...:.||....:.::...|:.:..
  Rat   232 ----VEVKFARTPVMSTYLVAFVVGEYDF----VETRS-KDGVCVRVYTPVGKAEQGKFALEVAA 287

  Fly   361 GVIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIA 425
            ..:.:|.|||.:.|||||:|:.||.||.:||||:|||||||||:||.|...|.::::|.:|.|:.
  Rat   288 KTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVG 352

  Fly   426 HEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGS 490
            ||.||.||||||||.||..|||||||||::|||.||..:||:.:..||..:.......||....|
  Rat   353 HELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNS 417

  Fly   491 HPIIQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTE 555
            |||..:|.:|.::.||||.|:||||:|::|||.|::|:..|::.:..||.:::...|.|.:.:..
  Rat   418 HPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWES 482

  Fly   556 IDKLELGYNVTEIMLTWTVQMGLPVVTI--EKVSDTE-YKLTQKRFLSNPNDYDADHEPSEFNYR 617
            ::... |..:..:|.|||.|||.|::.:  |:|.|.. .||:||:|.:: ..|..:..|     :
  Rat   483 LESAS-GKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKFCAS-GPYVGEDCP-----Q 540

  Fly   618 WSIPITYFTSSDSVVQRLWFYHDQSEITVTVPAAV--EWIKFNADQVGYYRVNYDTDLWNDLADQ 680
            |.:|||..||.|....:|....|:.|::|.:....  :|:|.|...||:||..|.:.:...|...
  Rat   541 WMVPITISTSEDPNQAKLKILMDKPEMSVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPG 605

  Fly   681 LVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAASRLTSLKRTLY 745
              ::..:...|||..|.||.|:||.:..:......::......|.:|..||..:..|..|...|.
  Rat   606 --IRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLS 668

  Fly   746 YTSTYAKYKKYATALIEPIYTALTW--TVGEDHLDNRLRVTALSAACSLGLESCLTEAGEQFNAW 808
            :|..|.:.:::...:..||...|.|  ..||.|||..||...|......|.::.|.||..:|...
  Rat   669 HTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKEH 733

  Fly   809 LAKPEDRPKADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLMYGLSAIQIPWILQRY 873
            : :.:....||:|..||...::. |.....|.:.:|........||:::...|.|...|.::|:.
  Rat   734 V-EGKQILSADLRSPVYLTVLKH-GDGTTLDIMLKLHKQADMQEEKNRIERVLGATLSPELIQKV 796

  Fly   874 IDLAWNEEYVRGQDYFTCLTYIS-ANPVGESLVWDYVRENWQRLVDRF--GLNERYLGNLIPSIT 935
            :..|.:|| ||.||..:.:..:: .:..|....|.::::||:.|.:|:  |.   .:..||....
  Rat   797 LTFALSEE-VRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGF---LISRLIKLSV 857

  Fly   936 ARFSTQTKLEEMEQFFAKYPEAGAGTAARV--RALETVKNNIVWLAENLEGVDAWL 989
            ..|:......|::.||..:|   |.:|.|.  :..|.:..|..||..:.:.:..:|
  Rat   858 EGFAVDKMAGEVKAFFESHP---APSAERTIQQCCENILLNAAWLKRDADSIHQYL 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	162/401 (40%)
		M1_APN_2	130..579	CDD:189008	179/457 (39%)
		ERAP1_C	655..969	CDD:288671	81/320 (25%)
Npepps	NP_536320.1	Peptidase_M1	54..442	CDD:279741	162/401 (40%)
		M1_APN_2	62..505	CDD:189008	179/457 (39%)
		ERAP1_C	580..891	CDD:288671	81/321 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820