DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and CG46339

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster

Alignment Length:	1056	Identity:	302/1056 - (28%)
Similarity:	486/1056 - (46%)	Gaps:	100/1056 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIVTAKLVAIGLGLALTAFTVS-TIVLAVQKANLK---------SDLRDAQEKLDLLEAGYTSTA 55
            :|:.|.:..:.|     .||:: |..:..|..|.|         :|..|. ....:..||:.|..
  Fly   159 LIIAAFITVLAL-----LFTIAITYFVTRQGLNPKEVTPPSCITADHPDV-NATPIQTAGWVSMN 217

  Fly    56 APTTASTANPGSTASPGSTAEPGSTAEPGSTAEPGSTASP---------GSTVTPGSTASTSEPG 111
            :|.....|.|...|||..|..|..|.   :.|.|.|:..|         |........|...|..
  Fly   218 SPPPLQAATPTPMASPTPTNTPTVTT---TLAMPASSEKPEIRMVDPKVGDIPVVEPAAGEVEDN 279

  Fly   112 TTASPEKIDYRLPGTLKPTHYDLYLFPNIETGEFSGQETITI--TVEEAT--DQIVLHSLNLNIS 172
            || .|.....:|....:|.||.|.:.|::.|...:|..||.|  .|.:.|  :.|||...|::||
  Fly   280 TT-KPINRPLKLYEGWRPLHYSLLIEPSVATSISNGSLTIEIERDVSKVTSWEPIVLDVHNVSIS 343

  Fly   173 SVSIMNTGSDTL------EILETTVDAVREFLIFQLNEPLTKGRTVR------LHIGFEGSMANK 225
            :|.::...:|..      :.|:...|...:...|.:|  |:|...|.      |.:.|...:.:.
  Fly   344 NVRVIRALADGASNASEEQDLDFDSDYGEDNATFVIN--LSKTLAVETQLRVLLSLDFVSQVTDT 406

  Fly   226 IVGLYSSSYVKED-ETRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMN 289
            :.|:|.:||...| :..:|:.:::|.|..||:||||||.|.:||.|:|::|.|. :...|||||.
  Fly   407 LQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPM-QFKMALSNMP 470

  Fly   290 VDSS--VSQGAFQEVTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLDKV 352
            ...|  ..:|..:: .|..:..|.|||..||||:....:::....|:  |..:.::..|:.:...
  Fly   471 KSGSRRFRRGFIRD-DFETTPKMPTYLVAFIVSNMVDSRLASQDSGL--TPRVEIWTRPQFVGMT 532

  Fly   353 DLAVTIGKGVIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDE---ATSSA 414
            ..|..:.:..:.||.|:|.|...|||:|:.::|||...|||:|||:|:|:::||..|   ..||:
  Fly   533 HYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSS 597

  Fly   415 TNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLH 479
            .:.|.:|.:||||.||.|||||||..||:||||.||||.::.|..::..:||::..|..|:....
  Fly   598 EHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFK 662

  Fly   480 SVLTLDGTLGSHPIIQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKY 544
            ..:..|....||.|...|.:.:.:..|||.|:||||:.|:|||...:|:..||.|..:.|.::.|
  Fly   663 ESMEHDADNTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAY 727

  Fly   545 STAETGNFFTEIDK-------LELGYNVTEIMLTWTVQMGLPVVTIEKVSDTEYKLTQKRFLSNP 602
            ...:..:.:..:.:       |....:|.:||.:|..|.|.|||.:|: ...:..|.|:|:|. |
  Fly   728 GNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNVER-RGADLVLRQERYLL-P 790

  Fly   603 NDYDADHEPSEFNYRWSIPITYFT----SSDSVVQRLWFYHDQSEITV-TVPA----AVEWIKFN 658
            :...||..      .|.||||:.|    ..|::........|:.|:.| .|.|    :...|..|
  Fly   791 SKNTADQS------TWFIPITFETDELRKGDNIPTHWMRSEDEEELIVGNVFAHSSNSDNVIYLN 849

  Fly   659 ADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFE-LTRYLD 722
            .::.||||||||...|..|.......|    .:.||.||:||..|:.:..|.|..... |....|
  Fly   850 LNRQGYYRVNYDMTSWLALKKNFSTLP----RITRAQLLDDALHLSQAEYLTYDIPLTFLMELFD 910

  Fly   723 KETDYVPWSVAASRLTSLKRTLYYTSTYAKYKKYATALIEPIYT--ALTWTVGEDHLDNRLRVTA 785
            ...|.:.|..|...|..|...|.....|..::.:...::.|.:.  .|.....|.||..:.|...
  Fly   911 AVDDELLWIAAKPGLNYLIYNLKREPAYETFRAFMKFIVRPAFDHYGLHEPDNESHLQLKHRALV 975

  Fly   786 LSAACSLGLESCLTEAGEQFNAWLAKPEDRP-KADVRETVYYYGIQSVGSQEDWDAVWELFVNES 849
            ...||....:.|..:|..:|..|:..|::.| |.:::..:|...: :.||..:|...::.:...:
  Fly   976 AYFACKFNYDRCTQKAQMKFREWMRDPKNNPIKPNLKSVIYCTSL-AEGSSPEWYFAYKQYKTTT 1039

  Fly   850 DASEKSKLMYGLSAIQIPWILQRYIDLAWN-EEYVRGQDYFTCLTYISANPVGESLVWDYVRENW 913
            .||||.:::..|.....||:|.:|:::..| ...:..||.......:::|.:|..:.:|:::.|.
  Fly  1040 SASEKEEILTSLGCTTKPWLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNI 1104

  Fly   914 QRLVDRFGLNERYLGNLIPSITARFSTQTKLEEMEQFFAKYPEAG--AGTAARVRALETVKNNIV 976
            :.:|:.:|.....|..:|.|:|...:......::....|...:.|  |..:|...|||.|.|||.
  Fly  1105 KEIVEYYGDGFSTLSEMIKSLTIYMNKDYHKHQLLDLAATCRKLGLHAVESAIELALEQVNNNIY 1169

  Fly   977 W-------LAENLEGV 985
            |       |...|||:
  Fly  1170 WRSHSYHSLKNFLEGI 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	139/414 (34%)
		M1_APN_2	130..579	CDD:189008	156/477 (33%)
		ERAP1_C	655..969	CDD:288671	77/320 (24%)
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	138/407 (34%)
		M1_APN_2	297..769	CDD:189008	156/477 (33%)
		ERAP1_C	846..1138	CDD:288671	72/296 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462048
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850