DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and CG14516

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster

Alignment Length:	1041	Identity:	339/1041 - (32%)
Similarity:	543/1041 - (52%)	Gaps:	126/1041 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VLAVQKANLKSDLRDAQEKLDLLEAGYTSTAAPTTASTANPGSTASPGSTAEPGSTAEPGSTAEP 89
            ::.|::..|..:|.        :|:...:.|.|||.:|.:.|......|.    :||...::...
  Fly     9 IMVVKEIPLHENLN--------MESRPMNAATPTTTTTFSKGGRRYSVSL----TTAILLASFFI 61

  Fly    90 GSTASPGSTVTPGSTASTSEP------------------GTTASPE-KIDYRLPGTLKPTHYDLY 135
            .:..:.|..|...:|.:..||                  |...:|: ..|.|||.:::|..|::.
  Fly    62 CTLLAVGFIVYNFATCAELEPDSDEDVVCTSYHLRRLKAGHDDTPKYDRDVRLPHSIRPLKYNIT 126

  Fly   136 LFPNIETG-EFSGQETITITVEEATDQIVLHSLNLNIS----SV-SIMNTG---SDTLEILETTV 191
            :.|.:... .|:|...|.|.|.|....|.:|:..||||    || .:.|.|   .|.|.|.:..:
  Fly   127 IEPQLSGNFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVHRVQNNGEPEGDGLRIHKQYL 191

  Fly   192 DAVREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDETRKWIATSKFEPTYARQ 256
            ...::|.:.:|.:.|.|.....:|:.|:|.:.:.:.|.|.|||...:||| |:|:::|:.|.||:
  Fly   192 VGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYEVHNETR-WVASTQFQATDARR 255

  Fly   257 AFPCFDEPALKAEFTITLVHPSGEDYHALSNMNVDSSVSQGAFQEVT---FAKSVPMSTYLACFI 318
            ||||||||||||.||:.:..|  .:...:|||.:.||..........   ||:|:||||||..:.
  Fly   256 AFPCFDEPALKANFTLHIARP--RNMTTISNMPIVSSNDHATMPSYVWDHFAESLPMSTYLVAYA 318

  Fly   319 VSDFAYKQVSIDTKGIGETFSMSVYATPEQLDKVDLAVTIGKGVIEYYIDYFQIAYPLPKLDMAA 383
            :|||.:  :|        :.:.:|:|..:.:...:.|:::|..::.:..|:|.:.:||||:||.|
  Fly   319 ISDFTH--IS--------SGNFAVWARADAIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMIA 373

  Fly   384 IPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLN 448
            :|:|.:||||:|||:|:|||::|||...::|.||||:|||:.||.||.|||||||.:||:|:|||
  Fly   374 LPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLN 438

  Fly   449 EGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPIIQTVENPDQITEIFDTITYS 513
            |||||::|||..|||.||||..|||.|:.|.:|..||....||.|...|.||.:|:||||.|:|:
  Fly   439 EGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHEVFNPQEISEIFDRISYA 503

  Fly   514 KGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTA---ETGNFFTEIDK----LELGYNVTEIMLT 571
            |||:::||:..||....||:.::.||.|..|::|   :..:|.|...|    |:...:|.|||.|
  Fly   504 KGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVKEIMDT 568

  Fly   572 WTVQMGLPVVTIEKVSDTE-YKLTQKRFL-SNPNDYDADHEPSEFNYRWSIPITYFTSSD----- 629
            ||:|.|.|||.:.:..::: .:|.|.||: :|....|.       :..|.||||:.|.|:
  Fly   569 WTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDE-------SLLWYIPITFTTDSELNFAN 626

  Fly   630 ----SVVQRLWFYH-DQSEITVTVPAAVEWIKFNADQVGYYRVNYDTDLWNDLADQLV------- 682
                :.:.|...|. :..|:::     .:|..||..|.||||||||.:.|..:.:.|:
  Fly   627 TRPTTWMPRTKLYELENRELSL-----AKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFED 686

  Fly   683 VQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAASRLTSLKRTLYYT 747
            :.|:     :||.|::|...||..:.|.|.||..|||||..|..:|||..|.|....:......:
  Fly   687 IAPA-----NRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNS 746

  Fly   748 STYAKYKKYATALIEPIYTALTWTVGEDHLDNRL----RVTALSAACSLGLESCLTEAGEQFNAW 808
            ..|...|.|....::.:|..:.:...:|..::.|    |...||.||.||.:.|:.||...|..|
  Fly   747 GDYDLLKNYLLKQLKKVYDQVGFKDSQDESEDILVKLKRADILSMACHLGHQECIAEASRHFQNW 811

  Fly   809 LAKP---EDRP-KADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLMYGLSAIQIPWI 869
            :..|   .:.| ..::|..||...|| .|::.:||..:|.|:..:...||..|:..|...:.||:
  Fly   812 MQTPNPDSNNPIVPNLRGVVYCSAIQ-YGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWL 875

  Fly   870 LQRYIDLAWNEEYVRGQDYFTCLTYISANPVGESLVWDYVRENWQRLVDRFGLNERYLGNLIPSI 934
            |.|::....:.:::|.||.|.....:|...||:::.:|::|.|||.:       :.|:|:.:.||
  Fly   876 LYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEI-------KTYMGSQMSSI 933

  Fly   935 -------TARFSTQTKLEEMEQFFAKYPEAGAGTAARVRAL-ETVKNNIVWLAENLEGVDAWLDK 991
                   |..|:::.:|.|.|.|   ..:|.......|:.: |.::.::.|:.:|.:.:..||:.
  Fly   934 HTLFKFATKGFNSKFQLGEFENF---VKDAHWDYDRPVQQIVEHIETSVDWMNKNYKSIVRWLEN 995

  Fly   992 Q 992
            :
  Fly   996 E 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	169/404 (42%)
		M1_APN_2	130..579	CDD:189008	192/467 (41%)
		ERAP1_C	655..969	CDD:288671	97/336 (29%)
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	169/404 (42%)
		M1_APN_2	121..576	CDD:189008	192/467 (41%)
		ERAP1_C	652..974	CDD:288671	97/337 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462040
Domainoid	1	1.000	133	1.000	Domainoid score	I3134
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm14800
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
	11	10.780