DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and CG32473

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster

Alignment Length:	902	Identity:	501/902 - (55%)
Similarity:	643/902 - (71%)	Gaps:	16/902 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 TVTPGSTASTSEPGTTASP---EKIDYRLPGTLKPTHYDLYLFPNIETGEFSGQETITITVEEAT 159
            |....|..:|..|...|:.   :.:.:|||..:||:.|.|:|.|::|...:||..:|::.|.|..
  Fly   116 TSKKSSIMATVAPAVKAASKVLQNLGFRLPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPI 180

  Fly   160 DQIVLHSLNLNISSVSIM---NTGSDTLEILETTVDAVREF--LIFQLNEPLTKGRTVRLHIGFE 219
            ..|.:|...||:|:|.:.   .:|:...:|..|...|..||  .:.:..:||..| ...|.:.|.
  Fly   181 AFIPVHVKQLNVSTVEVKRLDESGAPLKDITPTLTFAHPEFEYWVTEFEQPLEAG-NYSLLLNFT 244

  Fly   220 GSMANKIVGLYSSSYVKEDETR-KWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYH 283
            ||:.::|.|:|.|||:.:.:.| :.|.::|||||||||||||||||||||:||||:..|||::||
  Fly   245 GSLVDRITGMYQSSYLDKLKNRSRSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYH 309

  Fly   284 ALSNMNVDSSVSQGAFQEVTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQ 348
            .||||.|.|....|...|||||::||||||||.|:||||.||:.:::    |.:.::.|||.|.|
  Fly   310 VLSNMPVASEYVDGDITEVTFAETVPMSTYLAAFVVSDFQYKETTVE----GTSIALKVYAPPAQ 370

  Fly   349 LDKVDLAVTIGKGVIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSS 413
            ::|...|:....||:.|||:||.::|.|||||:.|||||||||||:|||||:|||:|||||:|||
  Fly   371 VEKTQYALDTAAGVMAYYINYFNVSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSS 435

  Fly   414 ATNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTL 478
            :.||||:|.|:|||.||.|||||||||||||||||||||||:||.||..::|||.|.:||.:..|
  Fly   436 SVNKQRVAIVVAHELAHQWFGNLVTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEEL 500

  Fly   479 HSVLTLDGTLGSHPIIQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYK 543
            |.|||:|.||.||||::::|:|.:|||.|||||||||::||||||:.:||...|.|.|.||..:.
  Fly   501 HPVLTIDATLASHPIVKSIESPAEITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHI 565

  Fly   544 YSTAETGNFFTEIDKLE-LGYNVTEIMLTWTVQMGLPVVTIEKVSDTEYKLTQKRFLSNPNDYDA 607
            ||||.|.::.|.:::.| |.::|.:||.|||.|||||||.:|| |.:.|||||||||:|.:||.|
  Fly   566 YSTATTEDYLTAVEEEEGLEFDVKQIMQTWTEQMGLPVVEVEK-SGSTYKLTQKRFLANEDDYAA 629

  Fly   608 DHEPSEFNYRWSIPITYFTSSDSVVQRLWFYHDQSEITVTVPAAVEWIKFNADQVGYYRVNYDTD 672
            :.|.|.|||||||||||.:|.:|.||.|.|.|:.:|.|:|:|....|||.|.:|||||||||.::
  Fly   630 EAEASSFNYRWSIPITYTSSINSEVQSLIFNHNDNEATITLPEEASWIKINTNQVGYYRVNYGSE 694

  Fly   673 LWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAASRL 737
            .|.:|...|......|.:.|||||||||..||.:.||.|:.|.:|..||:.|.|||||||..|.|
  Fly   695 QWAELISALKNSRETFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSAL 759

  Fly   738 TSLKRTLYYTSTYAKYKKYATALIEPIYTALTWTVGEDHLDNRLRVTALSAACSLGLESCLTEAG 802
            .:|:..:|||..|..|..||..|:.||...:|:||..|||:||||:..||:|||||.||.|.:|.
  Fly   760 ATLRNRVYYTDLYTNYTTYARKLLTPIVEKVTFTVAADHLENRLRIKVLSSACSLGHESSLQQAV 824

  Fly   803 EQFNAWLAKPEDRPKADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLMYGLSAIQIP 867
            ..||.|||.||.||..|:|:.|||||:|.|.::..||.||:|:::||||.||.|||..|:|:|:|
  Fly   825 TLFNQWLASPETRPNPDIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVP 889

  Fly   868 WILQRYIDLAWNEEYVRGQDYFTCLTYISANPVGESLVWDYVRENWQRLVDRFGLNERYLGNLIP 932
            |:|||||:.||:|..||.|||||.|.|||.||||:|||||||||||::||||||:|||.||.|||
  Fly   890 WLLQRYINWAWDESNVRRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIP 954

  Fly   933 SITARFSTQTKLEEMEQFFAKYPEAGAGTAARVRALETVKNNIVWLAENLEGVDAWL 989
            :|||||||:||||||:||||||||||||||||.:|||.||.||.|||.|...|..||
  Fly   955 TITARFSTETKLEEMQQFFAKYPEAGAGTAARQQALEAVKANIKWLAANKAQVGEWL 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	215/398 (54%)
		M1_APN_2	130..579	CDD:189008	242/455 (53%)
		ERAP1_C	655..969	CDD:288671	191/313 (61%)
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	215/398 (54%)
		M1_APN_2	151..602	CDD:189008	242/455 (53%)
		ERAP1_C	677..992	CDD:288671	192/314 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468259
Domainoid	1	1.000	261	1.000	Domainoid score	I1917
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	1	1.000	-	-		H68216
Inparanoid	1	1.050	633	1.000	Inparanoid score	I811
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm26111
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
	13	12.830