DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8773 and LTA4H

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_000886.1	Gene:	LTA4H / 4048	HGNCID:	6710	Length:	611	Species:	Homo sapiens

Alignment Length:	627	Identity:	135/627 - (21%)
Similarity:	237/627 - (37%)	Gaps:	163/627 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 TITITVEEATD---QIVLHSLNLNISSVSIMNTGSDTLEILETTVDAVREFLIFQLNEPLTKGRT 211
            |..:||:...|   .:||.:.:|.|..|.|  .|.:....|..........:...|...|:|.:.
Human    38 TAALTVQSQEDNLRSLVLDTKDLTIEKVVI--NGQEVKYALGERQSYKGSPMEISLPIALSKNQE 100

  Fly   212 VRLHIGFEGSMANKIVGLYSSSYVKEDETRKWIAT------------SKFEPTYARQAFPCFDEP 264
            :.:.|.||.|              .:....:|:..            |:.:..:.|...||.|.|
Human   101 IVIEISFETS--------------PKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTP 151

  Fly   265 ALKAEFTITLVHPSGEDYHALSNMNVDSSVSQGAFQE--------VTFAKSVPMSTYLACFIVSD 321
            ::|..:|..:..|  ::..||.     |::..|...:        ..|.:.||:..||...:|.
Human   152 SVKLTYTAEVSVP--KELVALM-----SAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVG- 208

  Fly   322 FAYKQVSIDTKGIG---------ETFSMSVYATPEQLDKVDLAVTIGKGVIEYYIDYFQIAYPLP 377
                  :::::.||         |....|.|...|....:.:|..:|.            .|...
Human   209 ------ALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGG------------PYVWG 255

  Fly   378 KLDMAAI-PDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMNW 441
            :.|:..: |.|..|.||:..|.....|.|..|::         :::|||||.:|.|.|||||...
Human   256 QYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKS---------LSNVIAHEISHSWTGNLVTNKT 311

  Fly   442 WNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTV-----STLHSVLTLDGTLGSHPIIQTVENPD 501
            |:..|||||...::|......::.| |.| .|..     ...:||.|...|   ||..:.|.:
Human   312 WDHFWLNEGHTVYLERHICGRLFGE-KFR-HFNALGGWGELQNSVKTFGET---HPFTKLVVD-- 369

  Fly   502 QITEI-----FDTITYSKGSSLVRMLEDFL-GETTFRQAVTNYLNEYKYSTAETGN--------F 552
             :|:|     :.::.|.||.:|:..||..| |...|...:..|:.::.|.:..|.:        |
Human   370 -LTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYF 433

  Fly   553 FTEIDKL-ELGYNVTEIMLTWTVQMGLPVVTIE---KVSDTEYKLTQKRFLSNPNDYD------- 606
            ..::|.| ::.:|      .|....|||.:...   .:::....|:|:...:..:|.:
Human   434 KDKVDVLNQVDWN------AWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDL 492

  Fly   607 ---ADHEPSEF----NYRWSIPI----------TYFTSSDSVVQRLWF-YHDQSEITVTVPAAVE 653
               :.|:.:||    ..|..:|:          .:...::|.::..|. ...||:....:|.|::
Human   493 KDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALK 557

  Fly   654 WIKFNADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAH 695
            .    |.:.|  |:.:...|:.|||        ||   |::|
Human   558 M----ATEQG--RMKFTRPLFKDLA--------AF---DKSH 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	91/407 (22%)
		M1_APN_2	130..579	CDD:189008	108/481 (22%)
		ERAP1_C	655..969	CDD:288671	11/41 (27%)
LTA4H	NP_000886.1	leuko_A4_hydro	6..608	CDD:274120	135/627 (22%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	135..137		0/1 (0%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	267..272		1/4 (25%)
		Inhibitor ARM1 binding. /evidence=ECO:0000269\|PubMed:24591641	362..365		1/2 (50%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	564..566		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810