DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and Psa

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster

Alignment Length:	882	Identity:	295/882 - (33%)
Similarity:	462/882 - (52%)	Gaps:	42/882 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 RLPGTLKPTHYDLYLFPNIETGEFSGQETITITVEEATDQIVLHSLNLNISSVSIMNTGSDTLEI 186
            |||..:.|.||:|.|.||::...|:|:..:.:.|:|.|.||.|::|::.:.||. ::.....|:.
  Fly   218 RLPTNVVPRHYELLLQPNLKEFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVE-LHFECSKLKP 281

  Fly   187 LETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDETRKWIATSKFEP 251
            .:....|..|....:..:.:.......||:.|.|.:.:|:.|.|.|.|...:...::...::||.
  Fly   282 EKIVYSAENETATLEFAQEIPAETQGVLHMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQFEA 346

  Fly   252 TYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNV--DSSVSQGAFQEVTFAKSVPMSTYL 314
            |.||:.|||:||||:||.|.||||.|  :|..|||||.|  :.|:..| .:.|.|.::..|||||
  Fly   347 TDARRCFPCWDEPAIKATFDITLVVP--KDRVALSNMPVIKEDSLPDG-LRRVRFDRTPIMSTYL 408

  Fly   315 ACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLDKVDLAVTIGKGVIEYYIDYFQIAYPLPKL 379
            ...:|.::.|.:...|     :...:.|:....:.::...|:.:...|:.||.|||.|||||||:
  Fly   409 VAVVVGEYDYVEGKSD-----DGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIAYPLPKM 468

  Fly   380 DMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMNWWND 444
            |:.||.||.:||||:|||||||||.:|.|...:|...||.||..:.||.||.||||||||.||..
  Fly   469 DLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTH 533

  Fly   445 LWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPIIQTVENPDQITEIFDT 509
            ||||||:|||||:|.|..::||:.:..||........|.||....||||...|.:|.:|.||||.
  Fly   534 LWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDE 598

  Fly   510 ITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTEIDKLELGYNVTEIMLTWTV 574
            |:|:||:|::|||.|::||.|||:.:..||..::|....|.:.:..:.:.. ..||:::|.:||.
  Fly   599 ISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEAS-SKNVSDVMTSWTQ 662

  Fly   575 QMGLPVVTIEKVSDTE----YKLTQKRFLSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVVQRL 635
            ..|.|||::|....::    .:|.|.:|       .||...::.|..|.:||:..||.:......
  Fly   663 HKGFPVVSVESEQTSKNQRLLRLKQCKF-------TADGSQADENCLWVVPISVSTSKNPTGIAK 720

  Fly   636 WFYHDQSEITVTVPAAVE--WIKFNADQVGYYRVNYDTDLWNDLADQLV--VQPSAFGSVDRAHL 696
            .|..|:|.:.||:....|  |||.|...|||||..|.    .::.:||:  |:......:||..|
  Fly   721 TFLLDKSSMEVTLDNVDEDDWIKINPGTVGYYRTRYS----QEMLEQLMPAVEKMELPPLDRLGL 781

  Fly   697 LNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAASRLTSLKRTLYYTSTYAKYKKYATALI 761
            ::|.||:..:.....|....|......||:|..|:...:.||:|...:.:|.....:.::...|.
  Fly   782 IDDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNLHILISHTDLMEDFHRFGRNLY 846

  Fly   762 EPIYTALTWTV--GEDHLDNRLRVTALSAACSLGLESCLTEAGEQFNAWLAKPEDRPKADVRETV 824
            ||:...|.|..  ||:|||..||...|:...|......:.||..:|...:...|..| ||:|.|.
  Fly   847 EPVAYRLGWEPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRRHVNGTELLP-ADLRTTC 910

  Fly   825 YYYGIQSVGSQEDWDAVWELFVNESDASEKSKLMYGLSAIQIPWILQRYIDLAWNEEYVRGQDYF 889
            |...:|. |.::.::.:.:|:.......|:.::...|.......:|:|.||.|.:.| ||.||..
  Fly   911 YKAVLQD-GDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFAMSSE-VRAQDSV 973

  Fly   890 TCLTYISANPVGESLVWDYVRENWQRLVDRF--GLNERYLGNLIPSITARFSTQTKLEEMEQFFA 952
            ..:..::.||.|..:.|::.:||.::|::|:  |.   .|..||..:...|:::.:.:|:|:|..
  Fly   974 FVIVAVAINPKGRDMAWEFFKENNKQLLERYQGGF---LLSRLIKYLIENFASEERAKEVEEFLQ 1035

  Fly   953 KYPEAGAGTAARVRALETVKNNIVWLAENLEGVDAWL 989
            .....|...... :|:||::.|..||..:.|.:..:|
  Fly  1036 VNQIPGCERTVS-QAVETIRLNAAWLQRDREQLAIFL 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	159/394 (40%)
		M1_APN_2	130..579	CDD:189008	177/450 (39%)
		ERAP1_C	655..969	CDD:288671	85/319 (27%)
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	159/394 (40%)
		M1_APN_2	227..667	CDD:189008	177/449 (39%)
		ERAP1_C	742..1052	CDD:288671	85/320 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462055
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850