DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and CG3502

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_611781.3	Gene:	CG3502 / 37695	FlyBaseID:	FBgn0046253	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	880	Identity:	244/880 - (27%)
Similarity:	406/880 - (46%)	Gaps:	76/880 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 DYRLPGTLKPTHYDLYLFPNIETGE--FSGQETITITVEEATDQIVLHSLNLNI--SSVSIMNTG 180
            |||||.:::|.||:|.:..::.:.:  |.|..||.:...|.|..|.||:..|.|  :..|:: :|
  Fly    27 DYRLPRSVEPLHYNLRILTHLNSTDQRFEGSVTIDLLARETTKNITLHAAYLKIDENRTSVV-SG 90

  Fly   181 SDTLEILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDETRK--- 242
            .:...:....|:.|..|.|..|...|.|.:..:|.:.|:..:.:...|.|.|:|.  |...|
  Fly    91 QEKFGVNRIEVNEVHNFYILHLGRELVKDQIYKLEMHFKAGLNDSQSGYYKSNYT--DIVTKEVH 153

  Fly   243 WIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNV------DSSVSQGAFQE 301
            .:|.::|.||:|||||||||||:.||.|.|||.:  .:.|..||.|.|      ||..:......
  Fly   154 HLAVTQFSPTFARQAFPCFDEPSWKATFNITLGY--HKKYMGLSGMPVLRCQDHDSLTNYVWCDH 216

  Fly   302 VTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLDKVDLAVTIGKGVIEYY 366
            .|..::   ||||..|.|.|.  :..:.:............:..|:.|.:..:::.|...::.:|
  Fly   217 DTLLRT---STYLVAFAVHDL--ENAATEESKTSNRVIFRNWMQPKLLGQEMISMEIAPKLLSFY 276

  Fly   367 IDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHM 431
            .:.|||.:||.|:|...:|.....|||:||||||.|..|..::.......|...|..:|||:||.
  Fly   277 ENLFQINFPLAKVDQLTVPTHRFTAMENWGLVTYNEERLPQNQGDYPQKQKDSTAFTVAHEYAHQ 341

  Fly   432 WFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPIIQT 496
            ||||||||||||||||.||.:::..||.:|::.|||:..::|....|.:..:.|.......|.:.
  Fly   342 WFGNLVTMNWWNDLWLKEGPSTYFGYLALDSLQPEWRRGERFISRDLANFFSKDSNATVPAISKD 406

  Fly   497 VENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTEIDKLEL 561
            |:||.::...|....|.|||..:|||...:||..|...:.::|..:.:......:.:..:....|
  Fly   407 VKNPAEVLGQFTEYVYEKGSLTIRMLHKLVGEEAFFHGIRSFLERFSFGNVAQADLWNSLQMAAL 471

  Fly   562 -------GYNVTEIMLTWTVQMGLPVVT-IEKVSDTEYKLTQKRFLSNPNDYDADHEPSEFNYRW 618
                   .:|::..|.:||:|.|.|:|| |......|..|.|.||..       :|...:.:..|
  Fly   472 KNQVISSDFNLSRAMDSWTLQGGYPLVTLIRNYKTGEVTLNQSRFFQ-------EHGIEKASSCW 529

  Fly   619 SIPITYFTSS----DSVVQRLWFYHDQSEITVTVP---AAVEWIKFNADQVGYYRVNYDTDLWND 676
            .:|:.:...:    :....:.|.....:...:.:|   :..||:..|......:|||||...|..
  Fly   530 WVPLRFVRQNLPDFNQTTPQFWLECPLNTKVLKLPDHLSTDEWVILNPQVATIFRVNYDEHNWRL 594

  Fly   677 LADQLVVQPSAFG--SVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAASRLTS 739
            :.:.|...|::.|  .:::|.||:|..|||......|..||:|..||.||.|::||..|...|..
  Fly   595 IIESLRNDPNSGGIHKLNKAQLLDDLMALAAVRLHKYDKAFDLLEYLKKEQDFLPWQRAIGILNR 659

  Fly   740 LKRTLYYTSTYAKYKKYATALIEPIYTALTWTVGEDHLDNRLRVT-----ALSAACSLGLESCLT 799
            | ..|...:...|:|.|...|:.|:|.......|.......::..     |.|.||...:..|..
  Fly   660 L-GALLNVAEANKFKNYMQKLLLPLYNRFPKLSGIREAKPAIKDIPFAHFAYSQACRYHVADCTD 723

  Fly   800 EA-----GEQFNAWLAKPEDRPKADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLMY 859
            :|     ..:....|..|.|..|      |.|..:...|...::..|:.||.|.::.|::..|..
  Fly   724 QAKILAITHRTEGQLELPSDFQK------VAYCSLLDEGGDAEFLEVFGLFQNSTNGSQRRILAS 782

  Fly   860 GLSAIQIPWILQRYIDLAW-NEEYVRGQDYFTCL-TYISANPVGESLVWDYVRENWQRLVDRFGL 922
            .|..::.....:::::... ::|.:.|..|...: :.::..|: .|...:|:..:.::|.::|
  Fly   783 ALGCVRNFGNFEQFLNYTLESDEKLLGDCYMLAVKSALNREPL-VSPTANYIISHAKKLGEKF-- 844

  Fly   923 NERYLGNLIPSITARF-STQ------TKLEEMEQF 950
            .::.|..|:.|:.... ||:      .:||::::|
  Fly   845 KKKELTGLLLSLAQNLRSTEEIDRLKAQLEDLKEF 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	134/405 (33%)
		M1_APN_2	130..579	CDD:189008	147/468 (31%)
		ERAP1_C	655..969	CDD:288671	75/317 (24%)
CG3502	NP_611781.3	Peptidase_M1	29..425	CDD:279741	134/405 (33%)
		M1_APN_2	37..496	CDD:189008	147/468 (31%)
		ERAP1_C	573..890	CDD:288671	75/317 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462028
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850