DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and Trhde

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_001102461.1	Gene:	Trhde / 366894	RGDID:	728895	Length:	1066	Species:	Rattus norvegicus

Alignment Length:	1048	Identity:	339/1048 - (32%)
Similarity:	516/1048 - (49%)	Gaps:	116/1048 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TAKLVAIGLGLALTAFTVSTI-VLAVQKANLKSDLRDAQEKLDLLEAGYTSTAAPTTASTANPGS 67
            |.:.:|:...|.| ||.||.: :|||....:...||     .|  |.|         ||.|.||:
  Rat    71 TERHIAVHKRLVL-AFAVSIVALLAVTMLAVLLSLR-----FD--ECG---------ASAAMPGT 118

  Fly    68 TASPGSTAEPGSTAEPGSTAEPGSTASPGSTVTPGSTASTSEPGTTASPEK-------------- 118
            ....|...|.|     |:::.|||...........|.....|.||..:|..
  Rat   119 DGGLGGFPERG-----GNSSYPGSARRNHHAGEESSQREIGEVGTAGTPSAHPPSEEEQEQWQPW 178

  Fly   119 IDYRLPGTLKPTHYDLYLFPNIETGEFSGQETITITVEEATDQIVLHSLNLNISSVSIMNTGSDT 183
            ...||.|.|||.||:|.|...:|...|||:..:.|..:.||..:|||:..:.:..|.:..
  Rat   179 TQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACQNATRYVVLHASRVAVEKVQVAE----- 238

  Fly   184 LEILETTVDAV----------REFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKED 238
                :....||          .:.|:..||..|...|...|.|.:...:.|:::|.:.||||...
  Rat   239 ----DRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFRSSYVIHG 299

  Fly   239 ETRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNVDSSVSQGAFQE-- 301
            | |:::..::|.||:||:||||||||..||.|.|::.|.:  .|.:||||.|::||    |:|
  Rat   300 E-RRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQA--TYLSLSNMPVETSV----FEEDG 357

  Fly   302 -VT--FAKSVPMSTYLACFIVSDFAYKQVSIDTK-GIGETFSMSVYATPEQLDK--VDLAVTIGK 360
             ||  |:::..||||...:.:.:|.|::.:  || |:    .:.:||.|:.:.:  .|.|:.|.|
  Rat   358 WVTDHFSQTPLMSTYYLAWAICNFTYRETT--TKSGV----VVRLYARPDAIRRGSGDYALHITK 416

  Fly   361 GVIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIA 425
            .:||:|.|||::.|.|||||:.|:|.....|||:|||..:.|..:|.|.:.||.:....:..||.
  Rat   417 RLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIV 481

  Fly   426 HEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQ-FTVSTLHSVLTLDGTLG 489
            ||..|.|||:|||..||.|:||.||||.:.|::|.|.:||.|.|..| |....||.|:.|||...
  Rat   482 HEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPSWNMEKQRFLTDVLHEVMLLDGLAS 546

  Fly   490 SHPIIQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTA---ETGN 551
            |||:.|.|.....|.::||.|.|.||::|:|||.:|:|.:.|::.:.:||..:||..|   :..|
  Rat   547 SHPVSQEVLRATDIDKVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWN 611

  Fly   552 FFTEIDKLELGY-NVTEIMLTWTVQMGLPVVTI--EKVSDTEYKLTQKRFLSNPNDYDADHEPSE 613
            ..:|..|....| |:.|:|..||:|||.||:||  ...::....:||:.|:     ||...:...
  Rat   612 TLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNMTAENRILITQQHFI-----YDIGAKTKA 671

  Fly   614 F-----NYRWSIPITYFTSSDSVVQR---LWFYHDQSEITVTVPAAVEWIKFNADQVGYYRVNYD 670
            .     :|.|.||:|....:.|.|..   :|..:......:|......||..|.:|.||:|||||
  Rat   672 LQLQNSSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWILGNINQTGYFRVNYD 736

  Fly   671 TDLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAAS 735
            ...|..|.|||:.........:||.|::|||:||.:..||.....|:.|||.:|.|::||..|:.
  Rat   737 LRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASR 801

  Fly   736 RLTSLKRTLYYTSTYAKYKKYATALIEPIYTALTW--------TVGEDHLDNRLRVTALSAACSL 792
            .|..|.:.|.....|..:.:|....:...|:.|.|        .|...:....||...:..|||.
  Rat   802 ALYPLDKLLDRMENYNIFNEYILKQVATTYSKLGWPKNNFNGSVVQASYQHEELRREVIMLACSF 866

  Fly   793 GLESCLTEAGEQFNAWLAKPEDRPKADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKL 857
            |.:.|..:|....:.|::...:|...:||:.||..|: |:..::.|:.:|..|.:.:..|||..|
  Rat   867 GNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGV-SLLDEDVWEFIWMKFHSTTAVSEKKIL 930

  Fly   858 MYGLSAIQIPWILQRYIDLAWNEEYVRGQDYFTCLTYISANPVGESLVWDYVRENWQRLVDRFG- 921
            :..|:......:|.|.::|:.|.|.|..||....:.:::.||.|..|.|.:.|:.|:.|..|:|
  Rat   931 LEALTCSDDRNLLSRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGE 995

  Fly   922 ---LNERYLGNLIPSITARFSTQTKLEEMEQFFAKYPEAGAGTAARVRALETVKNNIVWLAENLE 983
               :|.:    ||..:|...:|:.:|:|::.|...|.  |..:|:..||:|||:.|:.|.....:
  Rat   996 ALFMNSK----LISGVTEFLNTEGELKELKNFMKSYD--GVASASFSRAVETVEANVRWKRLYQD 1054

  Fly   984 GVDAWLDK 991
            .:..||.|
  Rat  1055 ELFQWLGK 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	155/411 (38%)
		M1_APN_2	130..579	CDD:189008	175/471 (37%)
		ERAP1_C	655..969	CDD:288671	98/325 (30%)
Trhde	NP_001102461.1	M1_APN-Q_like	190..635	CDD:341064	171/466 (37%)
Trhde	NP_001102461.1	ERAP1_C	720..1044	CDD:403137	102/330 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920