DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and CG31445

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster

Alignment Length:	914	Identity:	314/914 - (34%)
Similarity:	484/914 - (52%)	Gaps:	78/914 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 YRLPGTLKPTHYDLYLFPNIETGE---FSGQETITITVEEATDQIVLHSLNLNI--SSVSIMN-T 179
            ||||..|:|..|.|.:...:|:.:   |:|...|.|...:.|..|.|||.||.|  |.:::.. :
  Fly    27 YRLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLRQIS 91

  Fly   180 GSDTLE--ILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDETRK 242
            |:..::  :..|:|:...::.||...:.|..|...:|.:.|...:..::.|.|.||| |:..|.|
  Fly    92 GAGNMDNCVSSTSVNPTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSY-KDPVTNK 155

  Fly   243 --WIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNV-----DSSVSQGAFQ 300
              |::.::|||:.||:||||||||..||.|.:||.:  .:.::|||||.|     ..|::...:.
  Fly   156 TRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGY--HKQFNALSNMPVREIRPHESLANYIWC 218

  Fly   301 EVTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLDKVDLAVTIGKGVIEY 365
            |  |.:||||||||..:.|:||::|..::....:..|     :|.|..:|:.|.|...|..|::|
  Fly   219 E--FQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRT-----WARPNAIDQCDYAAEFGPKVLQY 276

  Fly   366 YIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAH 430
            |.::|.|.|||||:|..|:|||.:||||:||||.|||::|||....||..:||.:|:|||||.||
  Fly   277 YEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAH 341

  Fly   431 MWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPIIQ 495
            .||||||||.||.|||||||||::|..|||..:||||..||:.:::.|.:...||..:.||||.:
  Fly   342 QWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISR 406

  Fly   496 TVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTEI---- 556
            .::...:|.|.||.|:|.|||:::||:..|:||.:||..:..||..|.|..||..|.:..:
  Fly   407 PIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAA 471

  Fly   557 ---DKLELGYNVTEIMLTWTVQMGLPVVTIEK-VSDTEYKLTQKRFLSNPNDYDADHEPSEFNYR 617
               ..|...|::..||.:||:|.|.||:.|.: .|....::||:|:|.|.....||....
  Fly   472 HQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQIPQADRVGC----- 531

  Fly   618 WSIPITYFTSSD----SVVQRLWFYHDQSEITVTVPAAV-------EWIKFNADQVGYYRVNYDT 671
            |.:|::|.|..:    :...:.|.  :.|.....||..:       ||:..|......|:.|||.
  Fly   532 WWVPLSYTTQDENDFNNTSPKAWM--ECSSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDA 594

  Fly   672 DLWNDLADQLVVQPSAFGS---VDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVA 733
            ..|..|.|.|  ....|.|   ::||.|::|....|.:.:..|.||.::|.||.:|.|.:||..|
  Fly   595 RNWKLLIDTL--NSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSA 657

  Fly   734 ASRLTSLKRTLYYTSTYAKYKKYATALIEPIYTAL-----TWTVGEDHLDNRLRVTALSAACSLG 793
            ...|..|.|.|..|..:..:|:|...|:.|||..|     |:::.....:..|:.|.::.||...
  Fly   658 LDNLKLLNRILRQTPNFGSFKRYMQKLLTPIYEHLHGMNDTFSLMTQQDEVLLKTTVVNVACQYD 722

  Fly   794 LESCLTEAGEQFNAWLAK---PEDRP-KADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEK 854
            :..|:|:|...|..|.|:   .|:.| ..::|.|||...| |.|::|||:.:|..:...:.|||:
  Fly   723 VSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAI-SQGTEEDWNFLWSRYRKSNVASER 786

  Fly   855 SKLMYGLSAIQIPWILQRYIDLAWN-EEYVRGQDYFTCLTYISANPVGESLVWDYVRENWQRLVD 918
            ..::..|...:..||||||::.::: :..:|.||...|...:::..||..|...|..||.:.:..
  Fly   787 QTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIENVELIHK 851

  Fly   919 RFGLNERYLGNLIPSITARFSTQTKLEEMEQF------FAKYPEAGAGTAARVRALETVKNNIVW 977
            .:....|.:..|:..::.:.||...|.:...|      |.|    |...|.: ::|||:..|:.|
  Fly   852 YYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLK----GIRQAMQ-QSLETMLTNVQW 911

  Fly   978 LAEN 981
            :..|
  Fly   912 MDWN 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	168/407 (41%)
		M1_APN_2	130..579	CDD:189008	188/470 (40%)
		ERAP1_C	655..969	CDD:288671	93/332 (28%)
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	168/407 (41%)
		M1_APN_2	43..497	CDD:189008	186/463 (40%)
		ERAP1_C	578..904	CDD:288671	94/333 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462029
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm14800
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	10	9.750