DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8773 and lnpep

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	XP_021331684.1	Gene:	lnpep / 322814	ZFINID:	ZDB-GENE-030131-1534	Length:	1026	Species:	Danio rerio

Alignment Length:	999	Identity:	327/999 - (32%)
Similarity:	526/999 - (52%)	Gaps:	91/999 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 QEKLDLLEAGYTSTAAPTTASTANPGST----ASPGSTAEPGSTAEPGSTAE------------- 88
            :..:|..|..|.|:|.....|..|..|:    ||..:..:|.::..|.||..
Zfish    69 ENDMDEDEEDYESSARLLGMSFMNRSSSQRSAASSYTRQQPSNSCSPLSTKTTAVGVLILVLVVS 133

  Fly    89 --------PGST---------ASPGSTVTPGSTASTSEPGTTASPEKIDYRLPGTLKPTHYDLYL 136
                    |..|         .|..|::.|.||:....|.|       |.|||.::.|.||::.|
Zfish   134 MFMVIYFVPSCTFTKKGCQKSNSSMSSIYPISTSGELFPWT-------DLRLPVSVHPVHYNISL 191

  Fly   137 FPNIETGEFSGQETITITVEEATDQIVLHSLNLNISSVSIMNTGSDTLEILETTVDAVREFLIFQ 201
            .|::.:..|.|..:|.:.|...|..|:|||.::||..|:..:.....||.......|::
Zfish   192 HPDLNSMTFQGNVSIVVLVMHETKNIILHSSDMNIIKVTFDDKEYRFLEYKPWQQIAIK------ 250

  Fly   202 LNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDETRKWIATSKFEPTYARQAFPCFDEPAL 266
            ..|.|.||:.| |...::.:::|...|.|:||||....|::.:|.::|||..||:|||||||||.
Zfish   251 FPEDLKKGQYV-LKFSYKANLSNSYDGFYNSSYVDTAGTKRVLAATQFEPLAARKAFPCFDEPAF 314

  Fly   267 KAEFTITLVHPSGEDYHALSNMN--VDSSVSQGAFQEVTFAKSVPMSTYLACFIVSDFAYKQVSI 329
            |:.|.:.:...:  .|.:||||.  ..:.:::...||..|..||.|||||..|||::|     |.
Zfish   315 KSTFVVKMTREA--KYISLSNMPKIKTTDLNENGLQEDEFESSVKMSTYLVAFIVAEF-----SS 372

  Fly   330 DTKGIGETFSMSVYATPEQLDKVDLAVTIGKGVIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEH 394
            .:|.:.:| ::||||.|::.|:|..|:.....::::|..:|:|.|||.|||:.|||||::||||:
Zfish   373 HSKNVSKT-TVSVYAVPDKKDQVHYALETACKLLKFYNTFFEIEYPLSKLDLVAIPDFLAGAMEN 436

  Fly   395 WGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLG 459
            |||:|:|||:||... .||..:||.:.||||||.||.||||||||.||||||||||||::::|:.
Zfish   437 WGLITFRETTLLVGN-QSSRFDKQLVTSVIAHELAHQWFGNLVTMRWWNDLWLNEGFATYMQYMS 500

  Fly   460 VDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPIIQTVENPDQITEIFDTITYSKGSSLVRMLED 524
            ::.|:|:..:..:| ::.....|..|....|||:...|..|:|:.|:||:::|.||:|::.||..
Zfish   501 IENVFPDLDIDIEF-LNVRFKALAKDALNSSHPVSTFVSTPEQVEEMFDSVSYEKGASILLMLNA 564

  Fly   525 FLGETTFRQAVTNYLNEYKYSTAET---GNFFTEIDKLELGYNVTEIMLTWTVQMGLPVVTIEKV 586
            .|.:..|.:.|..||..|..|..|:   .|..:::.|..|  ||:|:|.||||..|.|:||:::
Zfish   565 TLRDGEFHKGVIEYLQNYNLSNTESKDLWNSLSQVSKQSL--NVSEMMNTWTVHKGFPLVTVKR- 626

  Fly   587 SDTEYKLTQKRFLSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVVQ--RLWFYHDQSEITVTVP 649
            :..:..|:|:.||.|..:...|      :..|.||:||...|.||::  :..|:....|.|:.:|
Zfish   627 NGPQVTLSQEHFLLNAENGTDD------SSLWHIPLTYVNDSCSVLRSCKQVFHLKDKEATLQLP 685

  Fly   650 AAVEWIKFNADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATA 714
            ..|:|:|||....|:|.|:||...|:||...|.|..:...|.|:|.|:|:.|||:...::.:...
Zfish   686 GQVKWLKFNFRSDGFYIVHYDEQGWSDLISALKVDVNVLPSEDKAALINNIFALSRLGKVSFRQV 750

  Fly   715 FELTRYLDKETDYVPWSVAASRLTSLKRTLYYTSTYAKYKKYATALIEPIYTAL----TWTVGED 775
            ..|..|:..||:..|.:.|.|:|..:.|.|...|. .......|..||..:.:|    :|.|...
Zfish   751 LNLMDYIRNETETAPLTEALSQLGQIYRLLDKRSD-LNLASSMTTYIESHFGSLMESQSWEVETS 814

  Fly   776 HLDNRLRVTALSAACSLGLESCLTEAGEQFNAWLAKPED-RPKADVRETVYYYGIQSVGSQEDWD 839
            .....||...|..||:|...:|.|:|...|:.|||..:. :..:|:..||:....:   :.|.|.
Zfish   815 VSKMTLRSALLETACALNRPNCTTQARRLFDQWLASNKTLQIPSDLMRTVFKVAAK---TDEGWS 876

  Fly   840 AVWELFVNESDASEKSKLMYGLSAIQ----IPWILQRYIDLAWNEEYVRGQDYFTCLTYISANPV 900
            .:...:.:....:||.|::..|::.|    |.|:||:.:|    ...::.|::...:..:..:..
Zfish   877 KLLGSYKHSIYDTEKRKMLEALASTQDVRKIIWVLQKSLD----GSEIQNQEFPLVIHTVCRDFA 937

  Fly   901 GESLVWDYVRENWQRLVDRFGLNERYLGNLIPSITARFSTQTKLEEMEQFFAKYPEAGAGTAARV 965
            |....||:::|||:::..:|.:....:.::|.|.|::|||:|.|.|::.||:.....|:......
Zfish   938 GYLYAWDFMKENWEKITQKFPIGSFAIQSIITSTTSQFSTKTHLAEVQNFFSSLGAKGSQMRIVQ 1002

  Fly   966 RALETVKNNIVWLAENLEGVDAWL 989
            .|:||:|:|:.|:.:||..:.:||
Zfish  1003 EAIETIKHNMRWMEKNLNTLQSWL 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	159/394 (40%)
		M1_APN_2	130..579	CDD:189008	180/453 (40%)
		ERAP1_C	655..969	CDD:288671	87/322 (27%)
lnpep	XP_021331684.1	M1_APN_2	185..620	CDD:189008	180/453 (40%)
lnpep	XP_021331684.1	ERAP1_C	690..1009	CDD:314669	90/326 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920