DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and CG31198

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	931	Identity:	284/931 - (30%)
Similarity:	476/931 - (51%)	Gaps:	112/931 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 EPGTTASPEKIDYRLPGTLKPTHYDLYLFPN-IETG-----EFSGQETITITVEEATDQIVLHSL 167
            :|..|.:.|..:|||...:.|.:|::.|.|. :||.     .|.|:..|.:...:.|:.|.|||.
  Fly    29 QPPATLATELNEYRLAEHITPVNYNITLRPYLLETDGNKRFTFDGEVWIEVISNQTTNDIYLHSK 93

  Fly   168 NLNIS------------------SVSIMNTGSDTLEILETTVDAVREFLIFQLNEPLTKGRTVRL 214
            ||..|                  .:|..||.:...:|::.|....           ||...|..|
  Fly    94 NLTYSVREYWQKPTTEVANPTVIQISATNTTNYDTDIVKLTASTA-----------LTANTTYIL 147

  Fly   215 HIGFEGSMANKIVGLYSSSYVKEDETRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSG 279
            |..:.|.|.:.:.|.|.||||.::...||:.:::|:..:||:|||.||||..||.|.:||  ...
  Fly   148 HFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTL--KRH 210

  Fly   280 EDYHALSNMNVDS---SVSQGAFQEVTFAKSVP-MSTYLACFIVSDFAYKQVSIDTKGIGETFSM 340
            ..::::||..:.|   |..:|.|.:|  .|:.| |||||..||:|:|..::..          ..
  Fly   211 RTFNSVSNTRLISSYPSTEEGIFSDV--YKTTPKMSTYLLAFIISEFVARKDD----------DF 263

  Fly   341 SVYATPEQLDKVDLAVTIGKGVIE---YYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRE 402
            .|||.||...:......:|..::|   .|:|....:....|:||||||||.:||||:|||:||||
  Fly   264 GVYARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGNDKMDMAAIPDFSAGAMENWGLLTYRE 328

  Fly   403 TSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEW 467
            .|||.||:.::..::|.||:|:|||.||||||:|||..||:..|||||||.:.:|.|...|..:|
  Fly   329 RSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVEDKW 393

  Fly   468 KMRDQFTVSTLHSVLTLDGTLGSHPII-QTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTF 531
            ::..||.|..:.||:.:|.|..::|:. :....|..::.:|::|:|:||::.:||::..:||..|
  Fly   394 ELEKQFVVDQVQSVMAMDSTNATNPLSDENTYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQQF 458

  Fly   532 RQAVTNYLNEYKYSTAETGNFFTEIDKLELG----------YNVT--EIMLTWTVQMGLPVVTIE 584
            ::::..||.:|:|.::        :.:..||          ||.:  :|..::|.|:|.|::.:
  Fly   459 QKSLQEYLKKYEYQSS--------LPEYLLGAWQANWPNSSYNESSKDIFKSFTEQVGYPLINV- 514

  Fly   585 KVSDTEYKLTQKRFLSNPNDYDADHEPSEFNYRWSIPITYFTS-SDSVVQRLWFYHDQSEITVTV 648
            .|.:::...||||||...:|      .|:.:.::::||:|.|| :::.:.....:..:..:|.||
  Fly   515 TVGNSQVSFTQKRFLLKESD------GSDSSLKYTVPISYTTSETNNFLNTTPKFILKPNVTTTV 573

  Fly   649 P--AAVEWIKFNADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSV---DRAHLLNDAFALADSTQ 708
            .  :.::||..|..|.|||||.|..|.|:.:...|:.  :.:|.:   :||.:::|.|.||.:..
  Fly   574 QFNSTIKWIVVNIQQTGYYRVTYSDDNWHAIHHALIT--ANWGGIHENNRAQIVDDLFNLARAGY 636

  Fly   709 LPYATAFELTRYLDKETDYVPWSVAASRLTSLKRTLYYTSTYAKYKKYATALIEPIYTALTWTVG 773
            :.|....::..||..||:|:||:.|.:....|  |:...:..|.:..|...|....|..|.:...
  Fly   637 VTYNLTLDVIEYLQTETNYIPWTSAFNGFNYL--TIRLGNDTADFNYYIQTLTNKAYNQLGFNEA 699

  Fly   774 EDH--LDNRLRVTALSAACSLGLESCLTEAGEQFNAWLAKPEDRPKADVRETVYYYGIQSVGSQE 836
            .:.  ||..||...||.||..|...|:::|...|.:....|:     ::|.|||..|::. |.:.
  Fly   700 SNDTALDIYLRTKILSWACRYGSSDCISQAQGYFQSLATVPK-----NIRATVYCVGLRE-GGEA 758

  Fly   837 DWDAVWELFVNESDASEKSKLMYGLSAIQIPWILQRYIDLAWNEEYVRGQDYFTCL-TYISANPV 900
            ::.|::..|.||:.|:|::.|......::...::::..||..::| :|.||..:.| |..:.|..
  Fly   759 EFQALYNKFKNETVATEETLLQNSFGCVKTQSLIEKVFDLIISDE-IRRQDKSSVLATLYTENNE 822

  Fly   901 GESLVWDYVRENWQRLVDRFGLNERYLGNLIPSITARFSTQTKLEEMEQF----FAKYPEAGAGT 961
            ..|.|:..|.:.::.|.:..| ....:..:|.:|.|||:|..:|.::|.|    .||:   |:..
  Fly   823 NVSPVFALVTQKYEELAEAMG-GYSAVATVISNIAARFTTNQQLTDLENFNKANGAKF---GSSQ 883

  Fly   962 AARVRALETVKNNIVWLAENL 982
            |....|..|||.|:.|....|
  Fly   884 ATLTAAEATVKENLEWATAKL 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	147/424 (35%)
		M1_APN_2	130..579	CDD:189008	163/492 (33%)
		ERAP1_C	655..969	CDD:288671	89/323 (28%)
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	147/424 (35%)
		M1_APN_2	50..510	CDD:189008	163/492 (33%)
		ERAP1_C	582..898	CDD:288671	93/330 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	7	6.920