DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and TRHDE

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_037513.2	Gene:	TRHDE / 29953	HGNCID:	30748	Length:	1069	Species:	Homo sapiens

Alignment Length:	1047	Identity:	339/1047 - (32%)
Similarity:	514/1047 - (49%)	Gaps:	115/1047 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TAKLVAIGLGLALTAFTVSTI-VLAVQKANLKSDLRDAQEKLDLLEAGYTSTAAPTTASTANPGS 67
            |.:.:|:...|.| ||.||.: :|||....:...||     .|  |.|          ::|.||:
Human    75 TERHIAVHKRLVL-AFAVSLVALLAVTMLAVLLSLR-----FD--ECG----------ASATPGA 121

  Fly    68 TASPGSTAEPGSTAE-PGST------------AEPGSTASPGSTVTPGSTASTSEPGTTASPEKI 119
            ...|....|.|.... |||.            .|.|..||||:|.....:....||....:
Human   122 DGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQPPSEEEREPWEPWT---- 182

  Fly   120 DYRLPGTLKPTHYDLYLFPNIETGEFSGQETITITVEEATDQIVLHSLNLNISSVSIMNTGSDTL 184
            ..||.|.|||.||:|.|...:|...|||:..:.|....||..:|||:..:.:..|.:..
Human   183 QLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQLAE------ 241

  Fly   185 EILETTVDAV----------REFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDE 239
               :....||          .:.|:..||..|...|...|.|.:...:.|:::|.:.||||...|
Human   242 ---DRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYVLHGE 303

  Fly   240 TRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNVDSSVSQGAFQE--- 301
             |:::..::|.||:||:||||||||..||.|.|::.|.:  .|.:||||.|::||    |:|
Human   304 -RRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQA--TYLSLSNMPVETSV----FEEDGW 361

  Fly   302 VT--FAKSVPMSTYLACFIVSDFAYKQVSIDTK-GIGETFSMSVYATPEQLDK--VDLAVTIGKG 361
            ||  |:::..||||...:.:.:|.|::.:  || |:    .:.:||.|:.:.:  .|.|:.|.|.
Human   362 VTDHFSQTPLMSTYYLAWAICNFTYRETT--TKSGV----VVRLYARPDAIRRGSGDYALHITKR 420

  Fly   362 VIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAH 426
            :||:|.|||::.|.|||||:.|:|.....|||:|||..:.|..:|.|.:.||.:....:..||.|
Human   421 LIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVH 485

  Fly   427 EFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQ-FTVSTLHSVLTLDGTLGS 490
            |..|.|||:|||..||.|:||.||||.:.|::|.|.:||.|.|..| |....||.|:.|||...|
Human   486 EICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASS 550

  Fly   491 HPIIQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTA---ETGNF 552
            ||:.|.|.....|..:||.|.|.||::|:|||.:|:|.:.|::.:.:||..:||..|   :..|.
Human   551 HPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNT 615

  Fly   553 FTEIDKLELGY-NVTEIMLTWTVQMGLPVVTI--EKVSDTEYKLTQKRFLSNPNDYDADHEPSEF 614
            .:|..|....| |:.|:|..||:|||.||:||  ...::....:||:.|:     ||...:....
Human   616 LSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFI-----YDISAKTKAL 675

  Fly   615 -----NYRWSIPITYFTSSDSVVQR---LWFYHDQSEITVTVPAAVEWIKFNADQVGYYRVNYDT 671
                 :|.|.||:|....:.|.|..   :|..:......:|......|:..|.:|.||:|||||.
Human   676 KLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDL 740

  Fly   672 DLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAASR 736
            ..|..|.|||:.........:||.|::|||:||.:..||.....|:.|||.:|.|::||..|:..
Human   741 RNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRA 805

  Fly   737 LTSLKRTLYYTSTYAKYKKYATALIEPIYTALTW--------TVGEDHLDNRLRVTALSAACSLG 793
            |..|.:.|.....|..:.:|....:...|..|.|        .|...:....||...:..|||.|
Human   806 LYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFG 870

  Fly   794 LESCLTEAGEQFNAWLAKPEDRPKADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLM 858
            .:.|..:|....:.|::...:|...:||:.||..|: |:..::.|:.:|..|.:.:..|||..|:
Human   871 NKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGV-SLLDEDVWEFIWMKFHSTTAVSEKKILL 934

  Fly   859 YGLSAIQIPWILQRYIDLAWNEEYVRGQDYFTCLTYISANPVGESLVWDYVRENWQRLVDRFG-- 921
            ..|:......:|.|.::|:.|.|.|..||....:.:::.||.|..|.|.:.|:.|:.|..|:|
Human   935 EALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEA 999

  Fly   922 --LNERYLGNLIPSITARFSTQTKLEEMEQFFAKYPEAGAGTAARVRALETVKNNIVWLAENLEG 984
              :|.:    ||..:|...:|:.:|:|::.|...|.  |...|:..||:|||:.|:.|.....:.
Human  1000 LFMNSK----LISGVTEFLNTEGELKELKNFMKNYD--GVAAASFSRAVETVEANVRWKMLYQDE 1058

  Fly   985 VDAWLDK 991
            :..||.|
Human  1059 LFQWLGK 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	155/411 (38%)
		M1_APN_2	130..579	CDD:189008	175/471 (37%)
		ERAP1_C	655..969	CDD:288671	97/325 (30%)
TRHDE	NP_037513.2	M1_APN-Q_like	193..638	CDD:341064	171/466 (37%)
TRHDE	NP_037513.2	ERAP1_C	723..1047	CDD:403137	101/330 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920