DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8773 and ANPEP

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_001141.2	Gene:	ANPEP / 290	HGNCID:	500	Length:	967	Species:	Homo sapiens

Alignment Length:	944	Identity:	354/944 - (37%)
Similarity:	519/944 - (54%)	Gaps:	69/944 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 STASPGSTVTPGSTASTS-EPGTTASPEKI--DYRLPGTLKPTHYDL----YLFPNIETG--EFS 146
            :.:||.::.||.::|:|: ...||....|.  .||||.||||..|.:    ||.|| :.|  .|.
Human    41 ANSSPVASTTPSASATTNPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPN-DRGLYVFK 104

  Fly   147 GQETITITVEEATDQIVLHSLNLNIS-----SVSIMNTGS------DTLEILETTVDAVREFLIF 200
            |..|:..|.:||||.|::||..||.:     .|.:...|.      |..|::|.|     |:|:.
Human   105 GSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPT-----EYLVV 164

  Fly   201 QLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDETRKWIATSKFEPTYARQAFPCFDEPA 265
            .|...|.|.....:...|||.:|:.:.|.|.|.|: |...||.:||::.:...||::||||||||
Human   165 HLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYM-EGNVRKVVATTQMQAADARKSFPCFDEPA 228

  Fly   266 LKAEFTITLVHPSGEDYHALSNM---NVDSSVSQGAFQEVTFAKSVP-MSTYLACFIVSDFAY-- 324
            :||||.|||:||  :|..|||||   ...:.:.:.....||...:.| |||||..||||:|.|
Human   229 MKAEFNITLIHP--KDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVE 291

  Fly   325 KQVSIDTKGIGETFSMSVYATPEQL--DKVDLAVTIGKGVIEYYIDYFQIAYPLPKLDMAAIPDF 387
            ||.|   .|:    .:.::|.|..:  ...|.|:.:...::.::..::...|||||.|...:|||
Human   292 KQAS---NGV----LIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDF 349

  Fly   388 VSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFA 452
            .:||||:||||||||.|||:|..:||::||:|:.:|||||.||.|||||||:.||||||||||||
Human   350 NAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFA 414

  Fly   453 SFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPI---IQTVENPDQITEIFDTITYSK 514
            |:|||||.|...|.|.::|...::.::.|:.:|....|||:   ...:..|.||:|:||.|:|||
Human   415 SYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSK 479

  Fly   515 GSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTEIDK------LELGYNVTEIMLTWT 573
            |:|::|||..||.|..|:|.:.:||:.:.|......|.:..:.:      ::|...|.:||..||
Human   480 GASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWT 544

  Fly   574 VQMGLPVVTIEKVSDTEYKLTQKRFLSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVVQRLWFY 638
            :|||.||:|::..:.|   |:|:.||.:|:....  .||||||.|.:|||....... .|..|..
Human   545 LQMGFPVITVDTSTGT---LSQEHFLLDPDSNVT--RPSEFNYVWIVPITSIRDGRQ-QQDYWLI 603

  Fly   639 HDQSEITVTVPAAVEWIKFNADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLNDAFAL 703
            ..:::..:...:..||:..|.:..||||||||.:.|..:..||....||...::||.::||||.|
Human   604 DVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNL 668

  Fly   704 ADSTQLPYATAFELTRYLDKETDYVPWSVAASRLTSLKRTLYYTSTYAKYKKYATALIEPIY--- 765
            |.:.::|...|...|.:|.:|..|:||..|.|.|:..|.....:..|...|.|....:.|::
Human   669 ASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHF 733

  Fly   766 --TALTW-TVGEDHLDNRLRVTALSAACSLGLESCLTEAGEQFNAWLAKPEDRP-KADVRETVYY 826
              ....| .:.|:.:|....|.|:|.|||.|:..|.......|..|:..|.:.| ..::|.|||.
Human   734 RNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYC 798

  Fly   827 YGIQSVGSQEDWDAVWELFVNESDASEKSKLMYGLSAIQIPWILQRYIDLAWNEEYVRGQDYFTC 891
            ..| :.|.:|:||..||.|.|.:..:|..||...|:..:..|||.||:....|.:.:|.||..:.
Human   799 NAI-AQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATST 862

  Fly   892 LTYISANPVGESLVWDYVRENWQRLVDRFGLNERYLGNLIPSITARFSTQTKLEEMEQFFAKYPE 956
            :..|:.|.:|:.||||:|:.||::|.:.:|.......|||.::|.||||:.:|:::|||.....|
Human   863 IISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEE 927

  Fly   957 A--GAGTAARVRALETVKNNIVWLAENLEGVDAW 988
            .  |:||.|..:|||..|.||.|:.||.|.|..|
Human   928 TGFGSGTRALEQALEKTKANIKWVKENKEVVLQW 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	177/420 (42%)
		M1_APN_2	130..579	CDD:189008	194/482 (40%)
		ERAP1_C	655..969	CDD:288671	109/322 (34%)
ANPEP	NP_001141.2	Cytosolic Ser/Thr-rich junction	33..68		8/26 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..62		6/20 (30%)
		Metalloprotease	69..967		346/916 (38%)
		M1_APN-Q_like	84..545	CDD:341064	190/476 (40%)
		Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269\|PubMed:1350662, ECO:0000269\|PubMed:8887485	288..295		3/6 (50%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:22932899	352..356		3/3 (100%)
		ERAP1_C	619..946	CDD:403137	112/327 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12261
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.850