Protein Alignment CG8773 and Lnpep

DIOPT Version :10

• Sequence 1: NP_650273.2
• Gene: CG8773 / 41634
• FlyBaseID: FBgn0038135
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_766415.1
• Gene: Lnpep / 240028
• MGIID: 2387123
• Length: 1025
• Species: Mus musculus
• Alignment Length: 925
• Identity: 321/925 - (34%)
• Similarity: 493/925 - (53%)
• Gaps: 61/925 - (6%)

  Fly    95 PGSTVTPGSTASTSEPGTTASPEKID--------YRLPGTLKPTHYDLYLFPNIETGEFSGQETI 151
            |..|.|......|::......|...:        .|||..:.|..|:|.|.||:.:..|.|..||
Mouse   132 PRCTFTKEGCHKTNQSAELIQPVATNGKVFPWAQIRLPTAIIPLCYELSLHPNLTSMTFRGSVTI 196

  Fly   152 TITVEEATDQIVLHSLNLNISSVSIMNTGSD---TLEILETTVDAVREFLIFQLNEPLTKGRTVR 213
            ::...:.|..|:|||...|||.|:.|:..|.   .:||||.   ...|.:.....|||..|....
Mouse   197 SLQALQDTRDIILHSTGHNISRVTFMSAVSSQEKQVEILEY---PYHEQIAVVAPEPLLTGHNYT 258

  Fly   214 LHIGFEGSMANKIVGLYSSSYVKEDETRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPS 278
            |.|.:..:::|...|.|..:|..:...:|:.|.::|||..||.|||||||||.||.|.|.:..
Mouse   259 LKIEYSANISNSYYGFYGITYTDKSNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKITR-- 321

  Fly   279 GEDYHALSNMNVDSSV--SQGAFQEVTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMS 341
            .|.:.|||||...|||  .:|..|: .|::||.|||||..|||.:.  :.:|.|..|.    .:|
Mouse   322 NEHHTALSNMPKKSSVPAEEGLIQD-EFSESVKMSTYLVAFIVGEM--RNLSQDVNGT----LVS 379

  Fly   342 VYATPEQLDKVDLAVTIGKGVIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLL 406
            |||.||::.:|..|:.....::|:|..||:|.|||.|||:.|||||.:||||:|||:|:||.:||
Mouse   380 VYAVPEKIGQVHHALDTTIKLLEFYQTYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLL 444

  Fly   407 YDEATSSATNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRD 471
            ||.||||..:::.:..:||||.||.||||||||.||||||||||||:|:||..|:.::.|....:
Mouse   445 YDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSYE 509

  Fly   472 QFTVSTLHSVLTLDGTLGSHPIIQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVT 536
            .| :......:..|....||||..:|::.:||.|:||:::|.||:||:.||:.:|.|..||.||.
Mouse   510 DF-LDARFKTMRKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFRHAVI 573

  Fly   537 NYLNEYKYSTAETGNF---FTEIDKLELGYNVTEIMLTWTVQMGLPVVTIEKVSDTEYKLTQKRF 598
            .||:.:.|:..::.:.   |.|:....|  :|.::|.|||:|.|.|:||::: ..||..|.|:||
Mouse   574 LYLHNHSYAAIQSDDLWDSFNEVTDKTL--DVKKMMKTWTLQKGFPLVTVQR-KGTELLLQQERF 635

  Fly   599 LSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVVQ-RLWFYHDQSEITVTVPAAVEWIKFNADQV 662
            ...   ...:.:||:.::.|.|||:|.|...:..: |.....|:....:.:...|:|:|.|::..
Mouse   636 FLR---MQPESQPSDTSHLWHIPISYVTDGRNYSEYRSVSLLDKKSDVINLTEQVQWVKVNSNMT 697

  Fly   663 GYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDY 727
            |||.|:|..|.|..|.:||...|......|||:|:|:.|.||...::|...||:|..||..||..
Mouse   698 GYYIVHYAHDDWTALINQLKRNPYVLSDKDRANLINNIFELAGLGKVPLRMAFDLIDYLKNETHT 762

  Fly   728 VPWSVAASRLTSLKRTLYYTSTYAKYKKYATALIEPIYTAL-------TWTVGEDHLDNRLRVTA 785
            .|.:.|..: |:|   :|.......:...::.|:..::..|       |||.........||...
Mouse   763 APITEALFQ-TNL---IYNLLEKLGHMDLSSRLVARVHKLLQNQIQQQTWTDEGTPSMRELRSAL 823

  Fly   786 LSAACSLGLESCLTEAGEQFNAWLAK--PEDRPKADVRETVYYYGIQSVGSQEDWDAVWELFVNE 848
            |..||:..||:|.|.|...|::|:|.  .:..| .||..||:..|.:   :::.|..::.::.:.
Mouse   824 LEFACAHSLENCTTMATNLFDSWMASNGTQSLP-TDVMVTVFKVGAR---TEKGWLFLFSMYSSM 884

  Fly   849 SDASEKSKLMYGLSAIQ----IPWILQRYIDLAWNEEYVRGQDYFTCLTYISANPVGESLVWDYV 909
            ...:||:|::..|::.:    :.|:::..:|    .:.:|.|.....:..:..:..|..|.||:|
Mouse   885 GSEAEKNKILEALASSEDVHKLYWLMKSSLD----GDIIRTQKLSLIIRTVGRHFPGHLLAWDFV 945

  Fly   910 RENWQRLVDRFGLNERYLGNLIPSITARFSTQTKLEEMEQFFAKYPEAGAGTAARVRALETVKNN 974
            :|||.:||.:|.|....:.:::...|..|||:|.|.|::.||....||.........|||.::.|
Mouse   946 KENWNKLVHKFHLGSYTIQSIVAGSTHLFSTKTHLSEVQAFFENQSEATLKLRCVQEALEVIQLN 1010

  Fly   975 IVWLAENLEGVDAWL 989
            |.|:..||:.:..||
Mouse  1011 IQWMVRNLKTLSQWL 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	KLF9_13_N-like	<17..118	CDD:425361	5/22 (23%)
		M1_APN-Q_like	130..573	CDD:341064	187/450 (42%)
		ERAP1_C	654..973	CDD:463368	94/331 (28%)
Lnpep	NP_766415.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101
		M1_APN-Q_like	177..612	CDD:341064	188/449 (42%)
		ERAP1_C	689..1009	CDD:463368	94/331 (28%)