DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and Trhde

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_666353.2	Gene:	Trhde / 237553	MGIID:	2384311	Length:	1066	Species:	Mus musculus

Alignment Length:	1047	Identity:	339/1047 - (32%)
Similarity:	514/1047 - (49%)	Gaps:	114/1047 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TAKLVAIGLGLALTAFTVSTI-VLAVQKANLKSDLRDAQEKLDLLEAGYTSTAAPTTASTANPGS 67
            |.:.:|:...|.| ||.||.: :|||....:...||     .|  |.|         ||.|.||:
Mouse    71 TERHIAVHKRLVL-AFAVSIVALLAVTMLAVLLSLR-----FD--ECG---------ASAAMPGT 118

  Fly    68 TASPGSTAEPGSTAE-PGST------------AEPGSTASPGSTVTPGSTASTSEPGTTASPEKI 119
            ....|...|..|.:. |||.            .|.|...:||   ||.:...:.|......| ..
Mouse   119 DGGLGGFPERDSNSSFPGSARRNHHAGGESSQRESGEVGTPG---TPSAQPPSEEEREQWQP-WT 179

  Fly   120 DYRLPGTLKPTHYDLYLFPNIETGEFSGQETITITVEEATDQIVLHSLNLNISSVSIMNTGSDTL 184
            ..||.|.|||.||:|.|...:|...|||:..:.|....||..:|||:..:.:..|.:..
Mouse   180 QLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQVAE------ 238

  Fly   185 EILETTVDAV----------REFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDE 239
               :....||          .:.|:..||..|...|...|.|.:...:.|:::|.:.||||...|
Mouse   239 ---DRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFRSSYVIHGE 300

  Fly   240 TRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNVDSSVSQGAFQE--- 301
             |:::..::|.||:||:||||||||..||.|.|::.|.:  .|.:||||.|::||    |:|
Mouse   301 -RRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQA--TYLSLSNMPVETSV----FEEDGW 358

  Fly   302 VT--FAKSVPMSTYLACFIVSDFAYKQVSIDTK-GIGETFSMSVYATPEQLDK--VDLAVTIGKG 361
            ||  |:::..||||...:.:.:|.|::.:  || |:    .:.:||.|:.:.:  .|.|:.|.|.
Mouse   359 VTDHFSQTPLMSTYYLAWAICNFTYRETT--TKSGV----VVRLYARPDAIRRGSGDYALHITKR 417

  Fly   362 VIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAH 426
            :||:|.|||::.|.|||||:.|:|.....|||:|||..:.|..:|.|.:.||.:....:..||.|
Mouse   418 LIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVH 482

  Fly   427 EFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQ-FTVSTLHSVLTLDGTLGS 490
            |..|.|||:|||..||.|:||.||||.:.|::|.|.:||.|.|..| |....||.|:.|||...|
Mouse   483 EICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPAWNMEKQRFLTDVLHEVMLLDGLASS 547

  Fly   491 HPIIQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTA---ETGNF 552
            ||:.|.|.....|..:||.|.|.||::|:|||.:|:|.:.|::.:.:||..:||..|   :..|.
Mouse   548 HPVSQEVLRATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNT 612

  Fly   553 FTEIDKLELGY-NVTEIMLTWTVQMGLPVVTI--EKVSDTEYKLTQKRFLSNPNDYDADHEPSEF 614
            .:|..:....| |:.|:|..||:|||.||:||  ...::....:||:.|:     ||...:....
Mouse   613 LSEALRRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRILITQQHFI-----YDIGAKTKAL 672

  Fly   615 -----NYRWSIPITYFTSSDSVVQR---LWFYHDQSEITVTVPAAVEWIKFNADQVGYYRVNYDT 671
                 :|.|.||:|....:.|.|..   :|..:......:.......||..|.:|.||:|||||.
Mouse   673 QLQNSSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRIAYLDRGSWILGNINQTGYFRVNYDL 737

  Fly   672 DLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAASR 736
            ..|..|.|||:.........:||.|::|||:||.:..||.....|:.|||.:|.|::||..|:..
Mouse   738 RNWRLLIDQLIRNHEVLSVSNRAALIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRA 802

  Fly   737 LTSLKRTLYYTSTYAKYKKYATALIEPIYTALTW--------TVGEDHLDNRLRVTALSAACSLG 793
            |..|.:.|.....|..:.:|....:...|..|.|        .|...:....||...:..|||.|
Mouse   803 LYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPRNNFNGSLVQASYQHEELRREVIMLACSFG 867

  Fly   794 LESCLTEAGEQFNAWLAKPEDRPKADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLM 858
            .:.|..:|....:.|::...:|...:||:.||..|: |:..::.|:.:|..|.:.:..|||..|:
Mouse   868 NKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGV-SLLDEDVWEFIWMKFHSTTAVSEKKILL 931

  Fly   859 YGLSAIQIPWILQRYIDLAWNEEYVRGQDYFTCLTYISANPVGESLVWDYVRENWQRLVDRFG-- 921
            ..|:......:|.|.::|:.|.|.|..||....:.:::.||.|..|.|.:.|:.|:.|..|:|
Mouse   932 EALTCSDDRNLLSRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEA 996

  Fly   922 --LNERYLGNLIPSITARFSTQTKLEEMEQFFAKYPEAGAGTAARVRALETVKNNIVWLAENLEG 984
              :|.:    ||..:|...:|:.:|:|::.|...|.  |..:|:..||:|||:.|:.|.....:.
Mouse   997 LFMNSK----LISGVTEFLNTEGELKELKNFMKSYD--GVASASFSRAVETVEANVRWKRFYQDE 1055

  Fly   985 VDAWLDK 991
            :..||.|
Mouse  1056 LFQWLGK 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	155/411 (38%)
		M1_APN_2	130..579	CDD:189008	174/471 (37%)
		ERAP1_C	655..969	CDD:288671	98/325 (30%)
Trhde	NP_666353.2	M1_APN-Q_like	190..635	CDD:341064	170/466 (36%)
Trhde	NP_666353.2	ERAP1_C	720..1044	CDD:378732	102/330 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020