DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and LVRN

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_776161.3	Gene:	LVRN / 206338	HGNCID:	26904	Length:	990	Species:	Homo sapiens

Alignment Length:	1046	Identity:	334/1046 - (31%)
Similarity:	505/1046 - (48%)	Gaps:	139/1046 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TAFTVSTIVLAVQKANLKSDLRDAQEKLDLLEA--GYTSTAAPTTASTANPG-----STASPGST 74
            :.|.||..| |:..|.|.:.|..|   |.:|.|  |:.....|:..    ||     :.:||...
Human     7 SGFYVSRAV-ALLLAGLVAALLLA---LAVLAALYGHCERVPPSEL----PGLRDLEAESSPPLR 63

  Fly    75 AEPGSTAEPGSTAEPGSTASPGSTVTPGSTASTSEPGTTASPEKIDYRLPGTLKPTHYDLYLFPN 139
            .:|..|.:|.|..|...|.:|.:...||...              ..|||..|.|.||||.|:|.
Human    64 QKPTPTPKPSSARELAVTTTPSNWRPPGPWD--------------QLRLPPWLVPLHYDLELWPQ 114

  Fly   140 IETGE-------FSGQETITITVEEATDQIVLHSLNLNISSVSI---MNTGSDTLEILETTVDAV 194
            :...|       |:|:..||:....||.:::||||..:.....:   ::.|:....:....||.|
Human   115 LRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQDCERAEVRGPLSPGTGNATVGRVPVDDV 179

  Fly   195 -----REFLIFQLNEPLTKGRTVRLHIGFEGSMANKI-VGLYSSSYVKEDETRKWIATSKFEPTY 253
                 .|:::.:|:|||..|.:..|.:.|.|.:...: .||:.:.|..:.|.|..:| |:.|||:
Human   180 WFALDTEYMVLELSEPLKPGSSYELQLSFSGLVKEDLREGLFLNVYTDQGERRALLA-SQLEPTF 243

  Fly   254 ARQAFPCFDEPALKAEFTITLV-HPSGEDYHALSNM-----NVDSSVSQGAFQEVTFAKSVPMST 312
            ||..|||||||||||.|.||:: |||   |.|||||     :....|:...:...||:.:..|.|
Human   244 ARYVFPCFDEPALKATFNITMIHHPS---YVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPT 305

  Fly   313 YLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQL--DKVDLAVTIGKGVIEYYIDYFQIAYP 375
            ||..|::.|  |..|:...:|    ..:.::|..:.:  ...|.|:.|...:..:..|.|.|:|.
Human   306 YLVAFVICD--YDHVNRTERG----KEIRIWARKDAIANGSADFALNITGPIFSFLEDLFNISYS 364

  Fly   376 LPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMN 440
            |||.|:.|:|.|.:.|||:|||:.:.|:.||.:........|..|:.|::||..|.|||||||||
Human   365 LPKTDIIALPSFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMN 429

  Fly   441 WWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPIIQTVEN--PDQI 503
            |||::||||||||:.|:..::...|:....:.|..:.||::|..|..|.:..:...|||  ..:|
Human   430 WWNNIWLNEGFASYFEFEVINYFNPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEI 494

  Fly   504 TEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETG----NFFTEID---KLEL 561
            .|:||..|||||:|:.|||..||.|..|..|:.:||..:.||.||..    :|...||   .:.|
Human   495 QELFDIFTYSKGASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVIL 559

  Fly   562 GYNVTEIMLTWTVQMGLPVVTIE------KVSDTEYKLTQKRFLSNPNDYDADHEPSEFNYRWSI 620
            ...:..||.:||.|.|.||:|:.      |......:..:.|.|...||            .|.:
Human   560 PATIKNIMDSWTHQSGFPVITLNVSTGVMKQEPFYLENIKNRTLLTSND------------TWIV 612

  Fly   621 PITYFTSSDSVVQRL-WFYHDQS-----EITVTVPAAVEWIKFNADQVGYYRVNYDTDLWNDLAD 679
            ||.:.  .:...|.| |.  |||     |:.|: .:..:|:..|.:..||||||||...|..|..
Human   613 PILWI--KNGTTQPLVWL--DQSSKVFPEMQVS-DSDHDWVILNLNMTGYYRVNYDKLGWKKLNQ 672

  Fly   680 QLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAASRLTS--LKR 742
            ||...|.|...:.|..|::|||:|:.:..:...||.|||:||.:|.:.:.|......|.:  |..
Human   673 QLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEIIVWHTVLVNLVTRDLVS 737

  Fly   743 TLYYTSTYAKYKKYATALIEPIYTALTWTVGEDHL---DNRLRVTALS----AACSLGLESCLTE 800
            .:.....|:..|:|....:..|:...:..:.|:.|   |:.|.:.:|.    .||.||||.||..
Human   738 EVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQDDYLALISLEKLFVTACWLGLEDCLQL 802

  Fly   801 AGEQFNAWLAKPEDRPKADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLMYGLSAIQ 865
            :.|.|..|:..||:.....:::.|..||| ::||.::||.:...:.|.::..||.:|.|.:|..:
Human   803 SKELFAKWVDHPENEIPYPIKDVVLCYGI-ALGSDKEWDILLNTYTNTTNKEEKIQLAYAMSCSK 866

  Fly   866 IPWILQRYIDLAWNEEYVRGQDYFT-----CLTYISANPVGESLVWDYVRENWQRLVDRFGLNER 925
            .||||.||:      ||......||     .:..::::.||..:..|::..|||.:..|:|...
Human   867 DPWILNRYM------EYAISTSPFTSNETNIIEVVASSEVGRYVAKDFLVNNWQAVSKRYGTQS- 924

  Fly   926 YLGNLIPSITARFSTQTKLEEMEQFFAKYPEAGAGTAARVRA-LETVKNNIVWLAENLEG----- 984
             |.|||.:|....:|..::.|::|||:...|  .....||.| |:|:||      |||:.
Human   925 -LINLIYTIGRTVTTDLQIVELQQFFSNMLE--EHQRIRVHANLQTIKN------ENLKNKKLSA 980

  Fly   985 -VDAWL 989
             :.|||
Human   981 RIAAWL 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	150/418 (36%)
		M1_APN_2	130..579	CDD:189008	172/481 (36%)
		ERAP1_C	655..969	CDD:288671	100/328 (30%)
LVRN	NP_776161.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..91		11/46 (24%)
		Peptidase_M1	97..506	CDD:279741	150/418 (36%)
		M1_APN_2	105..577	CDD:189008	172/481 (36%)
		Substrate binding. /evidence=ECO:0000250	379..383		2/3 (67%)
		ERAP1_C	648..951	CDD:288671	96/311 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820