DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8773 and ENPEP

DIOPT Version :9

Sequence 1:NP_650273.2 Gene:CG8773 / 41634 FlyBaseID:FBgn0038135 Length:994 Species:Drosophila melanogaster
Sequence 2:NP_001968.3 Gene:ENPEP / 2028 HGNCID:3355 Length:957 Species:Homo sapiens


Alignment Length:946 Identity:364/946 - (38%)
Similarity:544/946 - (57%) Gaps:57/946 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 GSTASPGSTAEPGSTAEPGSTAEPGSTASPG------STVTPGSTASTSEPGTTASPEKIDYRLP 124
            |.|.|..|:.:.|....|..:..|.|||||.      ..:.|   ||..|.|     :..::|||
Human    38 GLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICP---ASEDESG-----QWKNFRLP 94

  Fly   125 GTLKPTHYDLYLFPNIETGEFSGQETITITVEEATDQIVLHSLNLNISSV-SIMNTGSDTLEILE 188
            ..:.|.||||::.|.:|...::|..:|:|.:...|..:.||.....|:.: .:.....|.:::..
Human    95 DFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRR 159

  Fly   189 TTVDAVREFLIFQLNEPLTKGRTVRLHI---GFEGSMANKIVGLYSSSYVKEDETRKWIATSKFE 250
            ......:|:::.:..|.||......|::   .|.|.:...:||.|.::|.:..:.:..:||. .|
Human   160 CFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATD-HE 223

  Fly   251 PTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNV--DSSVSQGAFQEVTFAKSVPMSTY 313
            ||.||::|||||||..||.:||::.||  ::|.|||||.|  :.||.. .:...||.||||||||
Human   224 PTDARKSFPCFDEPNKKATYTISITHP--KEYGALSNMPVAKEESVDD-KWTRTTFEKSVPMSTY 285

  Fly   314 LACFIVSDF-AYKQVSIDTKGIGETFSMSVYATPEQLDKVDLAVTIGKGVIEYYIDYFQIAYPLP 377
            |.||.|..| :.|::|...|      .:::|..|||....:.|..|.|.|.:|:.:||.:.|.||
Human   286 LVCFAVHQFDSVKRISNSGK------PLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLP 344

  Fly   378 KLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMNWW 442
            |||..|||||.:||||:|||:|||||:||||...|:::|:||:|:|:|||..|.||||:|||:||
Human   345 KLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWW 409

  Fly   443 NDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPIIQTVENPDQITEIF 507
            .|||||||||||.|:|||:....:|:||||..:..:..|...|..:.|||||.||..||:||.:|
Human   410 EDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVF 474

  Fly   508 DTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTEIDKLELGYNVTEIMLTW 572
            |.|:||||||::|||||::....|::....||.:|::..|:|.:|:..:::.. ...|.|:|.||
Human   475 DGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEAS-RLPVKEVMDTW 538

  Fly   573 TVQMGLPVVTIEKVSDTEYKLTQKRFLSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVVQRLWF 637
            |.|||.||:.:..|.:    :||||||.:|. .:....||:..|.|:||:.:  :.|::...:.|
Human   539 TRQMGYPVLNVNGVKN----ITQKRFLLDPR-ANPSQPPSDLGYTWNIPVKW--TEDNITSSVLF 596

  Fly   638 YHDQSE-ITV--TVPAAVEWIKFNADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLND 699
            ...:.| ||:  :.|:...::|.|.|.:|:|||||:...|:.:|..|.:....|.|.|||.|::|
Human   597 NRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDD 661

  Fly   700 AFALADSTQLPYATAFELTRYLDKETDYVPWSVAASRLTSLKRTLYYTS-------TYAKYKKYA 757
            |||||.:..|.|..|..||:||.:|.:::||....|.:|      |..|       .|...::|.
Human   662 AFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVT------YIISMFEDDKELYPMIEEYF 720

  Fly   758 TALIEPIYTALTWTVGEDHLDNRLRVTALSAACSLGLESCLTEAGEQFNAWLAKPEDRPKADVRE 822
            ...::||..:|.|....||:...||.:.|..||.:|....|..|...|..||......| .::|.
Human   721 QGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLP-VNLRL 784

  Fly   823 TVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLMYGLSAIQIPWILQRYIDLAWNEEYVRGQD 887
            .||.||:|:.|::..|:...|.:...|.|.||.||:|||::::...:|.||:||..:...::.||
Human   785 LVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQD 849

  Fly   888 YFTCLTYISANPVGESLVWDYVRENWQRLVDRFGLNERYLGNLIPSITARFSTQTKLEEMEQFFA 952
            .||.:.|||.|..|:::.|::::.||..||:|:.||.|.||.:: :|...|:|:.:|.:||.|||
Human   850 VFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIV-TIAEPFNTELQLWQMESFFA 913

  Fly   953 KYPEAGAGTAARVRALETVKNNIVWLAENLEGVDAW 988
            |||:||||...|.:.||||||||.||.::...:..|
Human   914 KYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREW 949

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8773NP_650273.2 Peptidase_M1 122..515 CDD:279741 171/399 (43%)
M1_APN_2 130..579 CDD:189008 192/455 (42%)
ERAP1_C 655..969 CDD:288671 118/320 (37%)
ENPEPNP_001968.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 44..83 12/41 (29%)
Peptidase_M1 92..482 CDD:279741 171/399 (43%)
M1_APN_2 100..545 CDD:189008 192/455 (42%)
Substrate binding. /evidence=ECO:0000269|PubMed:23888046, ECO:0007744|PDB:4KXA, ECO:0007744|PDB:4KXB, ECO:0007744|PDB:4KXC, ECO:0007744|PDB:4KXD 357..361 3/3 (100%)
ERAP1_C 617..931 CDD:288671 119/321 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158476
Domainoid 1 1.000 242 1.000 Domainoid score I2231
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H68216
Inparanoid 1 1.050 658 1.000 Inparanoid score I777
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 1 1.000 - - otm40383
orthoMCL 1 0.900 - - OOG6_100307
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3793
SonicParanoid 1 1.000 - - X67
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.790

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