DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8773 and T16G12.1

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_499230.2	Gene:	T16G12.1 / 176416	WormBaseID:	WBGene00011803	Length:	1890	Species:	Caenorhabditis elegans

Alignment Length:	958	Identity:	226/958 - (23%)
Similarity:	392/958 - (40%)	Gaps:	175/958 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 HYDLYLFPNI---------ETGEFSGQETITITVEEATDQIVLHSLNLNISSVSI---------- 176
            :|.|.|..||         |...||...|:|..:...|..|.:::..|....|||
Worm  1004 YYKLDLQVNIPGSGPYQWYENMTFSATSTVTFQLVSPTSSITINAHRLMFDPVSIRLYNENDENA 1068

  Fly   177 --------------MNTGSDTLEILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSM-ANKI 226
                          .:.|:.|:..:..||....::.:|               |.:.|.: .|..
Worm  1069 HTPIPIDFSKVMKDYDKGTVTIPTMNNTVLYPNQYSLF---------------IEYTGFIFQNPD 1118

  Fly   227 VGLYSSSYVKEDETRK-WIATSKFE--PTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSN- 287
            .|..|::|:.....|| ||.|:.||  |. ||...||:|||:.|.:|.:::.||:  |..||||
Worm  1119 EGDASNTYLGGLNNRKGWIFTTDFEGGPG-ARSLLPCWDEPSYKGQFEVSVFHPT--DMIALSNE 1180

  Fly   288 MNVDSSVSQGAFQEVTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLDKV 352
            :::..::....:....||.:..|||||....|..|:.......|   |....:..::..||..:.
Worm  1181 VDIQRTIYDNGWTTTKFATTNQMSTYLLALCVGHFSNLATVTRT---GVLTRVWTWSGMEQYGEF 1242

  Fly   353 DLAVTIGKGVIEYYIDYFQIAYPLPKLDMAAIPDFV--SGAMEHWGLVTYRETSLLYDEATSSAT 415
            .|.||  .|.|::..:||...:||.|||:.|:|::.  :||||:|||:....:..::|...::..
Worm  1243 ALNVT--AGTIDFMENYFSYDFPLKKLDVMALPEYTMNAGAMENWGLIIGEYSLFMFDPDYATTR 1305

  Fly   416 NKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKM----RDQFTVS 476
            :...:|...|||..|.|||::||::||||::||||||.:....|:|..:||...    .::|.::
Worm  1306 DITEVAETTAHEVVHQWFGDIVTLDWWNDIFLNEGFAQYWFANGIDNTFPEQHAYSIDYNRFYMN 1370

  Fly   477 TLHSVLTLDGTLG-SHPIIQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLN 540
              |..|..|...| :.|:|.  :.|    .:|....|.|||:|:.:|.:.|....|::.:::||.
Worm  1371 --HIALKYDCIPGVAKPVIS--DTP----PVFGIEPYYKGSALLNLLNNVLTPAVFQEGLSSYLT 1427

  Fly   541 EYKYSTAETGNFFTEIDKLELGYNVTE----------IMLTWTVQMGLPVVTIEKVSDTEYKLTQ 595
            :|.|..|...|.:|.:......:|:|:          .|..:|:|...|::|:.....:..:..|
Worm  1428 QYGYVNASPRNLWTSLTVAAQRHNITDWNGQPLDVSSFMDPYTLQTSYPIITLTLRGTSTVQANQ 1492

  Fly   596 KRFLSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVVQRLWF--YHDQSEITVTVPAAVEWIKFN 658
            :..:|:..             .|::|:  ||.:...:...||  :...::.|...|....:...|
Worm  1493 QSCMSDET-------------LWNVPL--FTQTPGALDFNWFVNFTGGNDATWLRPLPTGYRVDN 1542

  Fly   659 ADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDK 723
            |....:.|:|||...|..:..||:...:...|..||.||:||.....|.:.......:||.||..
Worm  1543 AGSTSFARINYDDKSWYSIQAQLLSNMNTMSSTTRAMLLDDANFFYQSGRWEMTKFLDLTLYLVN 1607

  Fly   724 ETDYVPWSVAASRLTSLKRTLYYTSTYAKYKKYATALIEPIYTALTWTV----GEDHL------D 778
            |....||..|....|.:.....|.......:.|...:.:...:...|..    ..|.:      .
Worm  1608 EDSLAPWEQAIEFFTEMLNRFQYQPEIDTVRNYVIQITKNAVSKFQWNTNGLWANDRIVQLLVNV 1672

  Fly   779 NRLRVTALSAACSLGLESCLTEAGEQFNAWLAK---------------PEDRPKADVRETVYYYG 828
            |.|.|...|...:|.|          ||.::.|               |      ::|:..|.||
Worm  1673 NNLAVNRQSRQVALTL----------FNNFVLKCKYSLSGTGKCSGIHP------NLRQPTYCYG 1721

  Fly   829 IQSVGSQEDWDAV---WELFVNESD--ASEKSKLMYGLSAIQIPWILQRYIDLAWNEEYVR---G 885
            ::...:.:|:..|   :..||..:.  .::.|.|:..|..:|         :|...:..:|   .
Worm  1722 LRQSNNIDDFTTVNNLYSWFVQNAGYLQTDGSNLLNALGCVQ---------NLDLQKTMLRSILS 1777

  Fly   886 QDY-FTCLTYISANPVGESLVWDYVRENWQRLVDR---FGLNERYLGNLIPSITARFSTQTKLEE 946
            .|| .:.|..|:.:.....::::::.:|.|.:::.   |.|       .:.::...:||..:||.
Worm  1778 GDYPPSLLNSIAVHDDSSDVLYNFLLDNTQDILNAPFDFSL-------YVKAMFQNWSTSNQLEL 1835

  Fly   947 MEQF--FAKYPEAGAGTA-ARVRALETVKNNIVWLAENLEGVDAWLDK 991
            .:.|  .:.|....|... ...:.:.||.:|..|:.........|:.|
Worm  1836 AKDFQNSSNYNLLNAAQKNIYKQGILTVNSNANWMLIYKTPFLEWIQK 1883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	120/428 (28%)
		M1_APN_2	130..579	CDD:189008	139/502 (28%)
		ERAP1_C	655..969	CDD:288671	69/353 (20%)
T16G12.1	NP_499230.2	M1_APN_2	88..549	CDD:189008
		ERAP1_C	640..931	CDD:314669
		Peptidase_M1	999..1402	CDD:279741	120/428 (28%)
		ERAP1_C	1542..1839	CDD:314669	66/328 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820