DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and Lta4h

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_032543.2	Gene:	Lta4h / 16993	MGIID:	96836	Length:	611	Species:	Mus musculus

Alignment Length:	658	Identity:	139/658 - (21%)
Similarity:	244/658 - (37%)	Gaps:	162/658 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 ASPEKIDYRLPGTLKPTHYDLYLFPNIETGEFSGQETITI-TVEEATDQIVLHSLNLNISSVSIM 177
            |||..:       .:..|..|....:......:|...:|: :.||....:.|.:.:|.|..|.|
Mouse    11 ASPASV-------CRTQHLHLRCSVDFARRTLTGTAALTVQSQEENLRSLTLDTKDLTIEKVVI- 67

  Fly   178 NTGSDTLEILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDETRK 242
             .|.:....|..:.......:...|...|:|.:.:.:.|.||.|              .:....:
Mouse    68 -NGQEVKYTLGESQGYKGSPMEISLPIALSKNQEIVIEISFETS--------------PKSSALQ 117

  Fly   243 WIAT------------SKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNVDSSVS 295
            |:..            |:.:..:.|...||.|.|::|..:|..:..|  ::..||.     |::.
Mouse   118 WLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVP--KELVALM-----SAIR 175

  Fly   296 QGAFQE--------VTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLDK- 351
            .|...:        ..|.:.||:..||...:|.....:|:...|         .|::..||::|
Mouse   176 DGEAPDPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRT---------LVWSEKEQVEKS 231

  Fly   352 ----------VDLAVTIGKGVIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLL 406
                      :.:|..:|...:  :..|..:..|         |.|..|.||:..|.....|.|.
Mouse   232 ANEFSETESMLKIAEDLGGPYV--WGQYDLLVLP---------PSFPYGGMENPCLTFVTPTLLA 285

  Fly   407 YDEATSSATNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRD 471
            .|::         :::|||||.:|.|.|||||...|:..|||||...::|......::.| |.|.
Mouse   286 GDKS---------LSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGE-KFRH 340

  Fly   472 QFTVSTLHSVLTLDGTLG-SHPIIQTV-----ENPDQITEIFDTITYSKGSSLVRMLEDFL-GET 529
            ...:.....:.....|.| |||..:.|     .:||   ..:.:|.|.||.:|:..||..| |..
Mouse   341 FHALGGWGELQNTIKTFGESHPFTKLVVDLKDVDPD---VAYSSIPYEKGFALLFYLEQLLGGPE 402

  Fly   530 TFRQAVTNYLNEYKYSTAET--------GNFFTEIDKL-ELGYNVTEIMLTWTVQMGLPVVTIE- 584
            .|...:..|:.::.|.:..|        .:|..::|.| ::.:|      ||....|||.|...
Mouse   403 VFLGFLKAYVKKFSYQSVTTDDWKSFLYSHFKDKVDLLNQVDWN------TWLYAPGLPPVKPNY 461

  Fly   585 --KVSDTEYKLTQKRFLSNPNDYD----------ADHEPSEF----NYRWSIPI----------T 623
              .:::....|:|:...:...|..          :.|:.:||    ..:..:|:          .
Mouse   462 DVTLTNACIALSQRWVTAKEEDLSSFSIADLKDLSSHQLNEFLAQVLQKAPLPLGHIKRMQEVYN 526

  Fly   624 YFTSSDSVVQRLWF-YHDQSEITVTVPAAVEWIKFNADQVGYYRVNYDTDLWNDLADQLVVQPSA 687
            :...::|.::..|. ...||:....:|.|::.    |.:.|  |:.:...|:.|||        |
Mouse   527 FNAINNSEIRFRWLRLCIQSKWEEAIPLALKM----ATEQG--RMKFTRPLFKDLA--------A 577

  Fly   688 FGSVDRAH 695
            |   |::|
Mouse   578 F---DKSH 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	91/430 (21%)
		M1_APN_2	130..579	CDD:189008	109/496 (22%)
		ERAP1_C	655..969	CDD:288671	11/41 (27%)
Lta4h	NP_032543.2	leuko_A4_hydro	6..608	CDD:274120	139/658 (21%)
		M1_LTA4H	6..450	CDD:189006	111/507 (22%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P09960	135..137		0/1 (0%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P09960	267..272		1/4 (25%)
		Leuk-A4-hydro_C	468..607	CDD:286244	24/132 (18%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P09960	564..566		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810