Protein Alignment CG8773 and Anpep

DIOPT Version :9

• Sequence 1: NP_650273.2
• Gene: CG8773 / 41634
• FlyBaseID: FBgn0038135
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_032512.2
• Gene: Anpep / 16790
• MGIID: 5000466
• Length: 966
• Species: Mus musculus
• Alignment Length: 1040
• Identity: 353/1040 - (33%)
• Similarity: 536/1040 - (51%)
• Gaps: 144/1040 - (13%)

  Fly     4 TAKLVAIGLGLALTAFTVSTIVLAVQKANLKSDLRDAQEKLDLLEAGYTSTAAPTTASTANPGST 68
            |..::.|.||:|.....::..|:..|:.|     |:|:          .|..|||.
Mouse    10 TLGILGILLGVAAVCTIIALSVVYAQEKN-----RNAE----------NSATAPTL--------- 50

  Fly    69 ASPGSTAEPGSTAEPGSTAEPGSTASPGSTVTPGSTASTSEPGTTASPEKIDYRLPGTLKPTHYD 133
                                ||||::..:|.||  ....|:|..       .||||.||.|..|.
Mouse    51 --------------------PGSTSATTATTTP--AVDESKPWN-------QYRLPKTLIPDSYR 86

  Fly   134 LYLFPNIETGE-----FSGQETITITVEEATDQIVLHSLNLNISSVS----IMNT-------GSD 182
            :.|.|.:....     |.|..|:..|..:.||.|::||..||.:...    ::.|       ..|
Mouse    87 VILRPYLTPNNQGLYIFQGNSTVRFTCNQTTDVIIIHSKKLNYTLKGNHRVVLRTLDGTPAPNID 151

  Fly   183 TLEILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDETRKWIATS 247
            ..|::|.|     |:|:..|...|.:||...:...|:|.:|:.:.|.|.|.|: |.:.:|.:||:
Mouse   152 KTELVERT-----EYLVVHLQGSLVEGRQYEMDSQFQGELADDLAGFYRSEYM-EGDVKKVVATT 210

  Fly   248 KFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNM--------NVDSSVSQGAFQEVTF 304
            :.:...||::||||||||:||.|.|||::|:  :..|||||        ..|.|.:...|.
Mouse   211 QMQAADARKSFPCFDEPAMKAMFNITLIYPN--NLIALSNMLPKESKPYPEDPSCTMTEFH---- 269

  Fly   305 AKSVP-MSTYLACFIVSDFAYKQV-SIDTKGIGETFSMSVYATPEQLD--KVDLAVTIGKGVIEY 365
              |.| |||||..:|||:|  |.: |:...|:    .:.::|.|..:|  :.|.|:.:...::.:
Mouse   270 --STPKMSTYLLAYIVSEF--KNISSVSANGV----QIGIWARPSAIDEGQGDYALNVTGPILNF 326

  Fly   366 YIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAH 430
            :..::..:|||||.|..|:|||.:||||:||||||||:||::|..:||.:||:|:.:|||||.||
Mouse   327 FAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRESSLVFDSQSSSISNKERVVTVIAHELAH 391

  Fly   431 MWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPI-- 493
            .|||||||:.|||||||||||||:|||||.|...|.|.::|...::.::.|:.:|....|||:
Mouse   392 QWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSS 456

  Fly   494 -IQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTEID 557
             ...::.||||.|:||:||||||:|::|||..||.|..|::.:::||:.|:||.....:.:..:.
Mouse   457 PADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDLFKKGLSSYLHTYQYSNTVYLDLWEHLQ 521

  Fly   558 K-------LELGYNVTEIMLTWTVQMGLPVVTIEKVSDTEYKLTQKRFL----SNPNDYDADHEP 611
            |       ::....|..||..|.:|||.||:|   |:....:::||.||    ||..      .|
Mouse   522 KAVNQQTAVQPPATVRTIMDRWILQMGFPVIT---VNTNTGEISQKHFLLDSKSNVT------RP 577

  Fly   612 SEFNYRWSIPITYFTSSDSVVQRLWFYHDQSEITVTVPAAVEWIKFNADQVGYYRVNYDTDLWND 676
            |||||.|..||.:..|...  ...|...::::......::.|||..|.:..|||.||||.:.|..
Mouse   578 SEFNYIWIAPIPFLKSGQE--DHYWLDVEKNQSAKFQTSSNEWILLNINVTGYYLVNYDENNWKK 640

  Fly   677 LADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAASRLTSLK 741
            |.:||....|....::||.:::|:|.||.:..:|...|.:.|.:|.||.:|:||..|.|.|....
Mouse   641 LQNQLQTDLSVIPVINRAQIIHDSFNLASAKMIPITLALDNTLFLVKEAEYMPWQAALSSLNYFT 705

  Fly   742 RTLYYTSTYAKYKKYATALIEPIY-----TALTW-----TVGEDHLDNRLRVTALSAACSLGLES 796
            .....:..|...|:|....:.|::     ....|     |:.|.:.:    :.|:|.|||.||:.
Mouse   706 LMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWVNRPPTLMEQYNE----INAISTACSSGLKE 766

  Fly   797 CLTEAGEQFNAWLAKPEDRP-KADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLMYG 860
            |.....|.::.|:..|.:.. ..::|.|||...| :.|.:|:|:..||.|.|.:..:|..||...
Mouse   767 CRDLVVELYSQWMKNPNNNTIHPNLRSTVYCNAI-AFGGEEEWNFAWEQFRNATLVNEADKLRSA 830

  Fly   861 LSAIQIPWILQRYIDLAWNEEYVRGQDYFTCLTYISANPVGESLVWDYVRENWQRLVDRFGLNER 925
            |:..:..|||.||:....|.:|:|.||..:.:..|::|..|..||||:||.||::|.:.:|....
Mouse   831 LACSKDVWILNRYLSYTLNPDYIRKQDTTSTIISIASNVAGHPLVWDFVRSNWKKLFENYGGGSF 895

  Fly   926 YLGNLIPSITARFSTQTKLEEMEQFFAKYPEAGAGTAARV--RALETVKNNIVWLAENLEGVDAW 988
            ...|||..:|.|||::.:|:::|||.|.....|.||..|.  :|||..:.||.|:.||.:.|..|
Mouse   896 SFANLIQGVTRRFSSEFELQQLEQFKADNSATGFGTGTRALEQALEKTRANIDWVKENKDAVFKW 960

  Fly   989  988
            Mouse   961  960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	168/423 (40%)
		M1_APN_2	130..579	CDD:189008	185/486 (38%)
		ERAP1_C	655..969	CDD:288671	106/326 (33%)
Anpep	NP_032512.2	Cytosolic Ser/Thr-rich junction	33..68		15/80 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..64		11/62 (18%)
		Metalloprotease	69..966		331/935 (35%)
		M1_APN-Q_like	84..545	CDD:341064	182/480 (38%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P15144	351..355		3/3 (100%)
		ERAP1_C	618..945	CDD:403137	109/331 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.850