DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and Enpep

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_031960.1	Gene:	Enpep / 13809	MGIID:	106645	Length:	945	Species:	Mus musculus

Alignment Length:	932	Identity:	349/932 - (37%)
Similarity:	534/932 - (57%)	Gaps:	46/932 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 TAEPGSTAEPGSTASPGSTVTPGSTASTSEPGTTASPEKIDYRLPGTLKPTHYDLYLFPNIETGE 144
            :.|..:|..|.......||..|....:........|.|..::|||..:.|.||||.:...:|...
Mouse    42 SCEQDTTPAPSQPPPEASTALPPQDQNVCPDSEDESGEWKNFRLPDFINPVHYDLEVKALMEEDR 106

  Fly   145 FSGQETITITVEEATDQIVLHSLNLNISSV-SIMNTGSDTLEILETTVDAVREFLIFQLNEPL-- 206
            ::|..||::.:.:.|..:.||.....|:.: .:.....:.:.|........:|:::.|..|.|
Mouse   107 YTGIVTISVNLSKPTRDLWLHIRETKITKLPELRRPSGEQVPIRRCFEYKKQEYVVIQAAEDLAA 171

  Fly   207 TKGRTV-RLHIGFEGSMANKIVGLYSSSYVKEDETRKWIATSKFEPTYARQAFPCFDEPALKAEF 270
            |.|.:| ||.:.|:|.:...:||.|.::|:::.:.|. ||.:..|||.||::|||||||..|:.:
Mouse   172 TSGDSVYRLTMEFKGWLNGSLVGFYKTTYMEDGQIRS-IAATDHEPTDARKSFPCFDEPNKKSTY 235

  Fly   271 TITLVHPSGEDYHALSNMNVD-SSVSQGAFQEVTFAKSVPMSTYLACFIVSDF-AYKQVSIDTKG 333
            :|:::||  ::|.|||||..: |.:....:::.||.|||||||||.||.|..| |.::.|...|
Mouse   236 SISIIHP--KEYSALSNMPEEKSEMVDDNWKKTTFVKSVPMSTYLVCFAVHRFTAIERKSRSGK- 297

  Fly   334 IGETFSMSVYATPEQLDKVDLAVTIGKGVIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLV 398
                 .:.||..|.|.:..:.|..|.:.|.:|:.|||.:.|.|||||..|||||.:||||:||||
Mouse   298 -----PLKVYVQPNQKETAEYAANITQAVFDYFEDYFAMEYALPKLDKIAIPDFGTGAMENWGLV 357

  Fly   399 TYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAV 463
            |||||:||||...|:::|:||:|||:|||..|.||||.|||:||:|||||||||||.|:|||:..
Mouse   358 TYRETNLLYDPLLSASSNQQRVASVVAHELVHQWFGNTVTMDWWDDLWLNEGFASFFEFLGVNHA 422

  Fly   464 YPEWKMRDQFTVSTLHSVLTLDGTLGSHPIIQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGE 528
            ..:|:|..|..:..:..|...|..:.|||::.||..|.:||.:||.|:||||:|::|||:|::..
Mouse   423 EKDWQMLSQVLLEDVFPVQEDDSLMSSHPVVVTVSTPAEITSVFDGISYSKGASILRMLQDWITP 487

  Fly   529 TTFRQAVTNYLNEYKYSTAETGNFFTEIDKLELGYN--VTEIMLTWTVQMGLPVVTIEKVSDTEY 591
            ..|::....||.:::::.|:|.:|:   |.|:...|  |.|:|.|||.|||.||||:    ....
Mouse   488 EKFQKGCQIYLKKFQFANAKTSDFW---DSLQEASNLPVKEVMDTWTSQMGYPVVTV----SGRQ 545

  Fly   592 KLTQKRFLSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVVQRLWFYH--DQSEITVTVPAAVE- 653
            .:||||||.: :..|....|||..|.|:||:.:..:.:|   |:..|:  |:..||:....:.:
Mouse   546 NITQKRFLLD-SKADPSQPPSELGYTWNIPVRWADNDNS---RITVYNRLDKGGITLNANLSGDA 606

  Fly   654 WIKFNADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELT 718
            ::|.|.|.:|:|||||:...|:.:|:.|....:.|.:.||:..::||||||.:..|.|..|..||
Mouse   607 FLKINPDHIGFYRVNYEGGTWDWIAEALSSNHTRFSAADRSSFIDDAFALARAQLLNYKIALNLT 671

  Fly   719 RYLDKETDYVPWSVAASRLTSLKRTLYYTS-------TYAKYKKYATALIEPIYTALTWTVGEDH 776
            .||..|.|::||....|.::      |..|       .|...:.|....::|:...|.|.....|
Mouse   672 MYLKSEEDFLPWERVISSVS------YIISMFEDDRELYPMIETYFQGQVKPVADLLGWQDTGSH 730

  Fly   777 LDNRLRVTALSAACSLGLESCLTEAGEQFNAWLAKPEDRPKADVRETVYYYGIQSVGSQEDWDAV 841
            :...||.:.|..||.:|....|..|.:.|::||......| .::|..||.||:|:.|::..|:..
Mouse   731 ITKLLRASILGFACKMGDREALGNASQLFDSWLKGSASIP-VNLRLLVYRYGMQNSGNEAAWNYT 794

  Fly   842 WELFVNESDASEKSKLMYGLSAIQIPWILQRYIDLAWNEEYVRGQDYFTCLTYISANPVGESLVW 906
            .|.:...|.|.||.||:|||::::...:|.||:::..:...::.||.||.:.|||.|..|:::.|
Mouse   795 LEQYQKTSLAQEKEKLLYGLASVKDVKLLARYLEMLKDPNIIKTQDVFTVIRYISYNSYGKTMAW 859

  Fly   907 DYVRENWQRLVDRFGLNERYLGNLIPSITARFSTQTKLEEMEQFFAKYPEAGAGTAARVRALETV 971
            ::::.||..||.||.:|:||||.:: :|...|:|:.:|.:|:.||||||.||||...|.:.||||
Mouse   860 NWIQLNWDYLVSRFTINDRYLGRIV-TIAEPFNTELQLWQMQSFFAKYPNAGAGAKPREQVLETV 923

  Fly   972 KNNIVWLAENLEGVDAWLDKQP 993
            ||||.||..|.:.:..|....|
Mouse   924 KNNIEWLNVNRQSIREWFASLP 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	168/398 (42%)
		M1_APN_2	130..579	CDD:189008	189/456 (41%)
		ERAP1_C	655..969	CDD:288671	111/320 (35%)
Enpep	NP_031960.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..77		6/33 (18%)
		Peptidase_M1	84..474	CDD:279741	168/398 (42%)
		M1_APN_2	92..537	CDD:189008	189/456 (41%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		3/3 (100%)
		ERAP1_C	608..922	CDD:288671	112/321 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848873
Domainoid	1	1.000	242	1.000	Domainoid score	I2215
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68216
Inparanoid	1	1.050	639	1.000	Inparanoid score	I819
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm42453
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.780