DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and Rnpepl1

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_852070.3	Gene:	Rnpepl1 / 108657	MGIID:	1914170	Length:	720	Species:	Mus musculus

Alignment Length:	832	Identity:	162/832 - (19%)
Similarity:	263/832 - (31%)	Gaps:	244/832 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 PGSTAEPGSTAEPGSTASPGSTVTPGSTASTSEPGTTASPEKIDYRLPGTLKPTHYDLYLFPNIE 141
            ||:.|.|   |.|.....|...|...|:|..             :||      .|..|.|....|
Mouse    11 PGAEAAP---ARPPPEPPPALDVASASSAQL-------------FRL------RHLQLGLELRPE 53

  Fly   142 TGEFSGQETITI---------TVEEATDQIVLHSLNLNISSVSIMNTGSDTLEILETTVDAVREF 197
            ..|.:|...:.:         .|.:|...:.|||::...:|                   ||.|.
Mouse    54 ARELAGCLVLELCALRPAPRALVLDAHPALRLHSVSFRRAS-------------------AVSES 99

  Fly   198 ------------------------------LIFQLNEPLT---KGRTVRLHIGFEGSMANKIVGL 229
                                          |.|:| :|.|   ...||.|....:.....:::..
Mouse   100 PCTFAFPAPGSGPPLPGFADAPGAESASCPLAFRL-DPFTDYGSSLTVTLPPEVQAHQPFQVILR 163

  Fly   230 YSSSYVKEDETRKWIATSKFEPTYA---------------RQAFPCFDEPALKAEFTITLVHPSG 279
            |:|:    |....|....  |.||.               |..|||||.||:|..::..:..|.|
Mouse   164 YTST----DAPAIWWLDP--ELTYGNAKPFVFTQGHSVCNRSFFPCFDTPAVKCTYSAVVKAPLG 222

  Fly   280 EDYHALSNMNVDSSVSQGAFQE----VTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSM 340
                    :.|..|.:|..:.|    ..|....|:..||...:..|.  |...|..:.
Mouse   223 --------VQVLMSATQSVYVEEEGLYHFHMEHPVPAYLVALVAGDL--KPADIGPRS------- 270

  Fly   341 SVYATPEQLDKVDLAVTIGKGVIEYYIDYFQIAY-PL--PKLDMAAI-PDFVSGAMEHWGLVTYR 401
            .|:|.|..|   ..|.:...|.:|.::...:..| |.  .:.|:..: |.|...|||: ..:|:.
Mouse   271 RVWAEPCLL---PTATSKLSGAVEQWLSAAERLYGPYMWGRYDIVFLPPSFPIVAMEN-PCLTFI 331

  Fly   402 ETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPE 466
            .:|:|..:        :.:...:.||.||.||||.||...|.::||:||.|::.:.......|..
Mouse   332 ISSILESD--------EFLVIDVIHEVAHSWFGNAVTNATWEEMWLSEGLATYAQRRITTETYGA 388

  Fly   467 --WKMRDQFTVSTLHSVLTLDGTLGSHPIIQTVE-------NPDQITEIFDTITYSKGSSLVRML 522
              ..:...|.:..||..:.|   ||....:..::       ||..:..:|   ||.||...|..|
Mouse   389 AFTCLETAFRLDALHRQMRL---LGEDSPVSKLQVKLEPGVNPSHLMNLF---TYEKGYCFVYYL 447

  Fly   523 EDFL-GETTFRQAVTNYLNEYKYSTAETG-------NFFTEIDKLELGYNVTEIMLTWTVQMGLP 579
            .... |...|...:..|:.:||:::....       :||.|:.:..:..........|....|.|
Mouse   448 SQLCGGPQRFDDFLRAYVEKYKFTSVVAQDLLDSFLSFFPELKEQSVDCRAGLEFERWLNATGPP 512

  Fly   580 VVTIEKVSDTEYKLTQKRFLSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVVQRLWFYHDQSEI 644
            :        .|..|:|...|:.|.:                          .:.:||......:.
Mouse   513 L--------AEPDLSQGSSLTRPVE--------------------------ALFQLWTAEPLEQA 543

  Fly   645 TVTVPAAVEWIKFNADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQL 709
            ..:..|                  .|...|.      ..|.:.|  :||         |.|.:.|
Mouse   544 AASASA------------------IDISKWR------TFQTALF--LDR---------LLDGSPL 573

  Fly   710 PYATAFELTRYLDKETDYVPWSVAASRLTSLKRTLYYTSTYAKYKKYATALIEPIYTALTWTVGE 774
            |......|::......|.:...:....|..:.|..||...: :.:::..:.:..:||...:   |
Mouse   574 PQEVVMSLSKCYSSLLDSMNAEIRIRWLQIVVRNDYYPDLH-RVRRFLESQMSRMYTIPLY---E 634

  Fly   775 DHLDNRLRVTALSAACSL------GLESCLTEAGEQFNAWLAKPEDRPKADV 820
            |.....|:..||......      .|...:.:...|.....|:|...|..|:
Mouse   635 DLCTGALKSFALEVFYQTQGRLHPNLRRTIQQILSQGLGPSAEPSTEPSTDL 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	100/466 (21%)
		M1_APN_2	130..579	CDD:189008	112/530 (21%)
		ERAP1_C	655..969	CDD:288671	29/172 (17%)
Rnpepl1	NP_852070.3	M1_LTA4H	29..507	CDD:189006	116/557 (21%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	321..325		2/3 (67%)
		Leuk-A4-hydro_C	524..668	CDD:312599	29/208 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..708		4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810