DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8773 and rnpepl1

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_001335117.1	Gene:	rnpepl1 / 100535895	ZFINID:	ZDB-GENE-030131-5522	Length:	692	Species:	Danio rerio

Alignment Length:	488	Identity:	107/488 - (21%)
Similarity:	188/488 - (38%)	Gaps:	120/488 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 VTPGSTASTSEPGTTASPEKIDYRLPGTLKPTHYDLYLFPNIETGEFSGQETITITVEEATDQIV 163
            |.||..:...:...:.....:|.::||.....  |::|             ::|..||..||  .
Zfish    75 VQPGVQSLILDTHPSLLIHSVDCKVPGASGAP--DVFL-------------SLTYRVEPFTD--Y 122

  Fly   164 LHSLNLNISSVSIMNTGSDTLEILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVG 228
            ..|||:.:.:..|....:..:.:..||.|..   .|:.|:..||.|:|..|......|:.|
Zfish   123 GSSLNITLPAAVIRPHRAFRVTVRYTTTDGP---AIWWLDAELTCGQTRPLVFTQGHSVCN---- 180

  Fly   229 LYSSSYVKEDETRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNVDSS 293
                                      |..|||||.||:|:.::.|:..|.|        :.|..|
Zfish   181 --------------------------RSFFPCFDTPAVKSTYSATVRVPEG--------VTVLMS 211

  Fly   294 VSQGAFQE----VTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQL----- 349
            .|:.|:.:    ..|:...|:..||...:..|..:..:...::         |:|.|..|
Zfish   212 ASRSAYSKQDRVFQFSMEYPVPAYLVALVAGDLQHADIGPRSR---------VWAEPCILTCAVS 267

  Fly   350 ---DKVDLAVTIGKGVIEYYI-DYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEA 410
               ..|:..:.:.:|:...|: ..:.:.: ||       |.|...|||: ..:|:..:|:|
Zfish   268 KLGGSVERWLNVAEGLFGPYVWGRYDLVF-LP-------PSFPIVAMEN-PCLTFIISSIL---- 319

  Fly   411 TSSATNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPE--WKMRDQF 473
                .:::.:...:.||.||.||||.||...|.::||:||.|::.:.......|.|  ..:...|
Zfish   320 ----ESQEFLLIDVIHEIAHGWFGNAVTNATWEEMWLSEGLATYAQRRITTEAYGEAFTCLETVF 380

  Fly   474 TVSTLHSVLTLDGTLGSHPIIQTVE-------NPDQITEIFDTITYSKGSSLVRMLEDFLGE-TT 530
            .:..||..:.|   ||.:..:..::       ||..:..:|   ||.||...|..|....|: ..
Zfish   381 RLDALHRQMRL---LGDNNPVSKLQAKFEPGVNPSSLMNLF---TYEKGFCFVSYLSQLCGDIKR 439

  Fly   531 FRQAVTNYLNEYKYSTAETGN-------FFTEI 556
            |...:..|:.::::|:....:       ||.|:
Zfish   440 FDSFLRAYIEKFRFSSVIAQDLLDFFLGFFPEL 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	92/414 (22%)
		M1_APN_2	130..579	CDD:189008	101/457 (22%)
		ERAP1_C	655..969	CDD:288671
rnpepl1	NP_001335117.1	M1_LTA4H	36..490	CDD:189006	107/488 (22%)
rnpepl1	NP_001335117.1	Leuk-A4-hydro_C	507..649	CDD:312599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810