DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8773 and anpep

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	XP_031755081.1	Gene:	anpep / 100492262	XenbaseID:	XB-GENE-981369	Length:	977	Species:	Xenopus tropicalis

Alignment Length:	1024	Identity:	355/1024 - (34%)
Similarity:	548/1024 - (53%)	Gaps:	94/1024 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VTAKLVAIGLGLALTAFTVSTIV-LAVQKANLKSDLRDAQEKLDLLEAGYTSTAAPTTASTANPG 66
            |:..::|:|:..|:.|  ||||: |||..:..|....|              .|.|...:|::.|
Frog     7 VSKLVLAVGIIFAVAA--VSTIIALAVVYSQEKGKNND--------------VAKPPETTTSSSG 55

  Fly    67 STASPGSTAEPGSTAEPGSTAEPGSTASPGSTVTPGSTASTSEPGTTASPEKIDYRLPGTLKPTH 131
            :                 |||...:||:..:|.|   ||.:::|..       .||||.||.|.|
Frog    56 T-----------------STATTTTTATATATAT---TAQSNDPWN-------KYRLPKTLSPVH 93

  Fly   132 YDLYLFPNIETGE-----FSGQETITITVEEATDQIVLHSLNLNISSVSI----MNTGSDTLEIL 187
            ||:.|.|.:....     |.|:.|......:|||.|::||..||.:..:.    :..|:..:.:.
Frog    94 YDVELQPFLVKNADGLYVFRGKSTAFFICNDATDLIIIHSNKLNHTKFNSFDAKLQDGATDVALK 158

  Fly   188 ETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDETRKWIATSKFEPT 252
            .|.....::||:.|....|..|:...|:..|.|.:|:.:.|.|.|.|: ||...|.|||::.:..
Frog   159 STFFQKDKQFLVVQAAANLVPGKQYGLYTEFVGELADDLAGFYRSEYL-EDGVTKIIATTQMQAP 222

  Fly   253 YARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNM-NVDSSVSQGAFQEVT---FAKSVPMSTY 313
            .||:|||||||||:||.|.|||.:  .:.|.|:||| .:|.|......|:.|   |.|:..||:|
Frog   223 DARKAFPCFDEPAMKATFNITLKY--RQPYKAMSNMREIDRSTVTEDGQQWTVSKFDKTPKMSSY 285

  Fly   314 LACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQL---DKVDLAVTIGKGVIEYYIDYFQIAYP 375
            |..||||:|.    ::...|......:.::...:.:   ::.:.|:::.|.:::::.:|::..||
Frog   286 LVAFIVSEFE----AVGDPGNATVTGVQIWGRKKAIQDENQGEYALSVTKPILDFFAEYYRTPYP 346

  Fly   376 LPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMN 440
            |||.|..|:|||.:||||:|||||||||:||:|:..||..||:|:.:|||||.||.|||||||:.
Frog   347 LPKSDQVALPDFSAGAMENWGLVTYRETALLFDDQVSSIGNKERVVTVIAHELAHQWFGNLVTIR 411

  Fly   441 WWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPII---QTVENPDQ 502
            |||||||||||||:|||||.|...|.|.::|...::.:|.|:.:|....|||:.   ..|.:|.:
Frog   412 WWNDLWLNEGFASYVEYLGADKAEPNWNIKDLIVLNDVHRVMAVDALASSHPLTSREDEVNSPSE 476

  Fly   503 ITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTEID-------KLE 560
            |:.:||:|.||||:|::|||.:||.|..|...:.:||..::||.....:.:|.:.       .::
Frog   477 ISALFDSIAYSKGASVIRMLSEFLTEPLFVDGLASYLKGFEYSNTVYSDLWTHLQWAVNNQTAVK 541

  Fly   561 LGYNVTEIMLTWTVQMGLPVVTIEKVSDTEYKLTQKRFLSNPNDYDADHEPSEFNYRWSIPITYF 625
            |...:.:||.||.:|||.|||.|:..:..   :|||.||.:|:....  .||.|:|:|.:||:|.
Frog   542 LPLPIKDIMDTWVLQMGFPVVKIDTATGV---VTQKHFLLDPDSVVT--RPSPFDYKWKVPISYK 601

  Fly   626 TSSDSVVQRLWFYHDQSEITVTVPAAVEWIKFNADQVGYYRVNYDTDLWNDLADQLVVQPSAFGS 690
            .||..  ..:|..::...:........:|:..|.:..||||||||.:.|:.|.:||.....|...
Frog   602 ISSKE--DNIWLQNESETVEDFKITGNDWLLVNLNVTGYYRVNYDDNNWSRLLNQLQTSHQAIPV 664

  Fly   691 VDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAASRLTSLKRTLYYTSTYAKYKK 755
            ::||.:::|||.||.:.|:....|.:.|:|:..:.:|:||..|.|.|:...:....|..:...||
Frog   665 INRAQIIDDAFNLARAKQITTIQALDTTKYISADREYMPWQAALSGLSYFTQMFDRTEVFGPMKK 729

  Fly   756 YATALIEPIYTAL-----TWTVGEDHL-DNRLRVTALSAACSLGLESCLTEAGEQFNAWLAKP-E 813
            |....:.|::...     .||.....| |....:..||.|||..:|.||..|.|.|:.|:|.| :
Frog   730 YMKMQVNPLFEYFKQETGNWTNRPVSLTDQYCEINTLSTACSYDIEDCLKFASELFSQWMATPQQ 794

  Fly   814 DRPKADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLMYGLSAIQIPWILQRYIDLAW 878
            :....::|..||...:...|.|| |:.||:.|.....|.|:.||...|:..:.||||.|:::.:.
Frog   795 NNIHPNLRTNVYCTAVAQGGEQE-WNFVWDRFQLTDIAQEQDKLRAALACSKEPWILNRFLEYSL 858

  Fly   879 NEEYVRGQDYFTCLTYISANPVGESLVWDYVRENWQRLVDRFGLNERYLGNLIPSITARFSTQTK 943
            :...:|.||..:.::.:..||:|:||.||:||..|:.|...||.:....||||..:|.||||:.:
Frog   859 DPTMIRRQDAVSTISSVVNNPIGQSLAWDFVRAKWKTLYSMFGESSFSFGNLIERVTRRFSTEFE 923

  Fly   944 LEEMEQFFAKYPEAGAGTAARV--RALETVKNNIVWLAENLEGVDAWLD 990
            |:::.||.|.....|.|||::.  :|:|..|.||.|:.:|...|..|.:
Frog   924 LQQLLQFKADNQNPGFGTASQALEQAIEKTKANINWVNQNKAAVKKWFE 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	165/411 (40%)
		M1_APN_2	130..579	CDD:189008	182/474 (38%)
		ERAP1_C	655..969	CDD:288671	108/322 (34%)
anpep	XP_031755081.1	M1_APN-Q_like	92..555	CDD:341064	179/469 (38%)
anpep	XP_031755081.1	ERAP1_C	628..955	CDD:403137	110/327 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110