DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8773 and erap2

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	XP_005165525.1	Gene:	erap2 / 100144556	ZFINID:	ZDB-GENE-080402-6	Length:	935	Species:	Danio rerio

Alignment Length:	956	Identity:	334/956 - (34%)
Similarity:	490/956 - (51%)	Gaps:	108/956 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 STASTSEPGTTASPEKIDY-----RLPGTLKPTHYDLYLFPNIETGEFSGQETITITVEEATDQI 162
            |:.|.|..|...:.:.:.:     |||..:.|.||.|.:.||:.|..|:|...|.|.|:..|:.:
Zfish    20 SSESNSPTGDNLATDGLPFPWSKVRLPNYIVPVHYHLLIHPNLTTLSFTGSVKIEIDVKNNTNWV 84

  Fly   163 VLHSLNLNISSVSIM-----NTGSDTLEILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSM 222
            ||||.||.|.:.:::     :....||.:||..:.  .:..||. .:.||.|....|::.|...:
Zfish    85 VLHSKNLKIYTATVLDEHEAHLSEKTLSVLEYPLH--EQIAIFS-PKILTSGEKYFLYLEFGAPL 146

  Fly   223 ANKIVGLYSSSY-VKEDETRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALS 286
            ::...|.|.|:| .|..|||. :|::.||||.||.|.||||||..||.:|:.:  ..|..:.|||
Zfish   147 SDGFHGFYKSTYRTKSGETRV-LASTHFEPTSARMALPCFDEPVFKANYTVRI--RRGPSHIALS 208

  Fly   287 NMNVDSSV--SQGAFQEVTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGET-FSMSVYATPEQ 348
            ||.::.:|  |.|.|:: .|..||.||:||..||:.||  |.||    |:..| .::|:||.||:
Zfish   209 NMPLEQTVEISNGLFED-HFEASVKMSSYLLAFIICDF--KSVS----GLTATGINISIYAVPEK 266

  Fly   349 LDKVDLAVTIGKGVIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSS 413
            ..:...|:.....::|:|..||.|.|||||||:.|||||.|||||:|||.||||||||||...||
Zfish   267 WHQTQYALEAALRLLEFYEQYFNILYPLPKLDLIAIPDFESGAMENWGLTTYRETSLLYDPDISS 331

  Fly   414 ATNKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTL 478
            |::|..:..||.||.||.||||||||:||||:|||||||.::|.:.|:|||||.|:.|.| :.|.
Zfish   332 ASDKLWVTMVIGHELAHQWFGNLVTMDWWNDIWLNEGFARYMESVSVEAVYPELKVEDHF-LDTC 395

  Fly   479 HSVLTLDGTLGSHPIIQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYK 543
            ...:..|....|.||....|:|.||.|:|||::|.||:.::.||..||.:..|:..:..||..:.
Zfish   396 FGAIGRDSLNSSRPISSLAESPTQIKEMFDTVSYEKGACILHMLRHFLTDEGFQSGIIRYLRRFS 460

  Fly   544 YSTAETGNFFTEIDKL---------ELGY-----------------NVTEIMLTWTVQMGLPVVT 582
            |..|...:.:..:.|.         |..|                 ::.::|.|||:|.|:|:||
Zfish   461 YCNARNEDLWDSLIKTCSEEDFAAGEYCYSSAQATKNAYRFAGEHVDLKKMMNTWTLQKGIPLVT 525

  Fly   583 IEKVSDTEYKLTQKRFLSNPNDYDADHEPSEFNYRWSIPITYFTS-SDSVVQRLWFYHDQSEITV 646
            ::: ...:..:.|:|||......|......:..|.|.||:||.|| ||..|:.:.   |:....:
Zfish   526 VKR-QGRKLHIGQERFLKIVLPDDPSWHSLQDGYLWHIPLTYKTSHSDHEVKHIL---DKKSDVL 586

  Fly   647 TVPAAVEWIKFNADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPY 711
            .:...|:|:|.|.|..|||.|:||.:.||.|.:.|.|..:|....|||.|:::||.|..:.:|..
Zfish   587 LLDEHVDWVKLNTDMNGYYIVHYDEEGWNALTELLKVNHTALSFKDRASLIHNAFQLVTAGRLSL 651

  Fly   712 ATAFELTRYLDKETDYVPWSVAASRLTSLKRTLYYTSTYAK-------------YKKYATALIEP 763
            ..|.:|..||..||..||          |.:.|.|..::.|             .|.|.....:.
Zfish   652 DRALDLIAYLKSETHNVP----------LLQGLGYLQSFYKLIEKRKIADVTHNLKTYILQYFKD 706

  Fly   764 IYTALTWTVGEDHL--DNRLRVTALSAACSLGLESCLTEAGEQFNAW------LAKPEDRPKADV 820
            :....:|:  :|.:  |.|||...||.||.|....||.:|...|.:|      ::.|     .||
Zfish   707 VIDKQSWS--DDGMVSDRRLREDVLSLACDLDYPPCLEKAERLFVSWVKSNGTISLP-----TDV 764

  Fly   821 RETVYYYGIQSVGSQEDWDAVWELFVNESDAS----EKSKLMYGLSAIQIPWILQRYIDLAWNEE 881
            .||||..|.|.       |:.|...:.:...|    ||||.:..|::.:....|.|.:.|.....
Zfish   765 SETVYMVGAQD-------DSGWVYLLRQYGVSMCETEKSKFLSALTSSKDSEKLSRLLQLGMEGT 822

  Fly   882 YVRGQDYFTCLTYISANPVGESLVWDYVRENWQRLVDRFGLNERYLGNLIPSITARFSTQTKLEE 946
            .::.|:..:.:..::.||||..|.||:|:::|..||::|.|....:..:|.....:||:..:|.|
Zfish   823 VIKTQNLPSLIYMVARNPVGHFLAWDFVKKHWNELVEKFPLGSFGIREIIVGTVTQFSSTEELRE 887

  Fly   947 MEQFFAKYPEAGAGTAARVRALETVKNNIVWLAENLEGVDAWLDKQ 992
            :|.||....|..:.......|.|.|:.|||||..|||.:..||.::
Zfish   888 VESFFKSIQEQVSQLRIIQVATENVEKNIVWLKRNLETMRTWLQRR 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	179/401 (45%)
		M1_APN_2	130..579	CDD:189008	195/483 (40%)
		ERAP1_C	655..969	CDD:288671	97/338 (29%)
erap2	XP_005165525.1	Peptidase_M1	44..432	CDD:279741	179/401 (45%)
		M1_APN_2	52..522	CDD:189008	195/483 (40%)
		ERAP1_C	595..911	CDD:288671	97/339 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920