DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8773 and LOC100004744

DIOPT Version :9

Sequence 1:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	XP_001920418.2	Gene:	LOC100004744 / 100004744	-ID:	-	Length:	935	Species:	Danio rerio

Alignment Length:	931	Identity:	338/931 - (36%)
Similarity:	495/931 - (53%)	Gaps:	82/931 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 TTAS---PEKIDYRLPGTLKPTHYDLYLFPNIETGE-----FSGQETITITVEEATDQIVLHSLN 168
            ||.|   |.| :||||.||.|.:|::.|:|.::..:     |:|..::.......||.|::|...
Zfish    35 TTESHVEPWK-EYRLPDTLFPHYYNITLWPRLQPDDHGLYVFTGNSSVVFKCLRETDIIIIHCNK 98

  Fly   169 LNISS-------VSIMNTGSDTLEILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSMANKI 226
            ||::|       :|..:| |:...:.:|.::.:.::|:.|||..|..|....|:..|.|.:|:.:
Zfish    99 LNLTSEDGYLAKLSAFST-SEVPSVKKTWIEEMTQYLVLQLNGKLKAGELYVLYTEFVGELADDL 162

  Fly   227 VGLYSSSYVKEDETRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSN---- 287
            .|||.|.| .||..:|.:|||:..||:||:.||||||||:||.|.|||:|..|.  .||||
Zfish   163 AGLYRSEY-DEDGEKKIVATSQMHPTHARKTFPCFDEPAMKAVFHITLIHDRGT--VALSNGMEI 224

  Fly   288 MNVDSSVSQGAFQEVTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLD-- 350
            .|||:.|........||..:..||:||...:|||  |..|   |...|..  :.::|..:.::
Zfish   225 ENVDTIVDGQPVTVTTFEPTKIMSSYLLALVVSD--YTNV---TSADGTL--IRIWARKKAIEDG 282

  Fly   351 KVDLAVTIGKGVIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSAT 415
            ..|.|:.|...:::::.:|:.:.|||.|.|..|:|||..||||:||||.|||::||||...||..
Zfish   283 HGDYALNITGPILKFFENYYNVPYPLSKSDQIALPDFYFGAMENWGLVMYRESNLLYDPTVSSNA 347

  Fly   416 NKQRIASVIAHEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHS 480
            ||:|.|::||||.||||||||||:.|||::||||||||:|.|||.|...|.|.::|...:..:|.
Zfish   348 NKERTATIIAHELAHMWFGNLVTLKWWNEVWLNEGFASYVSYLGADFAEPSWNVKDLIILKDVHR 412

  Fly   481 VLTLDGTLGSHPIIQTVEN---PDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEY 542
            |..:|....|||:....|:   |:||.|.|||::||||:|::|||.|||.|..|.|.:..||..:
Zfish   413 VFAVDALASSHPLSSKEEDIIKPEQIIEQFDTVSYSKGASVLRMLSDFLTEPVFVQGLNTYLTMF 477

  Fly   543 KYSTAETGNFFTEI-DKLELGYN---------VTEIMLTWTVQMGLPVVTIEKVSDTEYKLTQKR 597
                |:......:: |.|:...|         |..||..|.:|||.||||   |:.|..:::|..
Zfish   478 ----ADQNTVGEDLWDHLQTAVNKTGTVLPLSVKVIMDRWVLQMGFPVVT---VNTTTGQVSQMH 535

  Fly   598 FLSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVVQRLWF------YHDQSEITVTVPAAVEWIK 656
            ||.:|.  .:....|.|||.|.:||.:. .|..|..|.|.      |:|..      ....||:.
Zfish   536 FLLDPE--SSLQRTSPFNYEWIVPINWM-KSKMVQSRFWLLERTAVYNDMK------TTGSEWVL 591

  Fly   657 FNADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYL 721
            .|.:..||||||||...|..|.:||.........::||.:::|||.||.:..:|...|.:.|.||
Zfish   592 LNLNITGYYRVNYDIGNWERLLNQLAENHKVISVINRAQIVDDAFNLARAKIIPVTLALKTTTYL 656

  Fly   722 DKETDYVPWSVAASRLTSLKRTLYYTSTYAKYKKYATALIEPIYTALTWTVGED-------HLDN 779
            .:|.:|:||..|.:.|.........|..|...:.|....:.|::.... |:.||       |.|.
Zfish   657 SEEREYMPWQSALNNLDYFYLMFTQTEVYRLLQSYTKKQVTPLFDYFK-TITEDWSDVPSGHTDQ 720

  Fly   780 RLRVTALSAACSLGLESCLTEAGEQFNAWLAKPEDRP-KADVRETVYYYGIQSVGSQEDWDAVWE 843
            ..:|.|:..|||.|::.|.......:..|:.:|...| ..::|.|||...| :.|..|:||..|.
Zfish   721 YNQVNAIRFACSTGVDECQNLTSSWYKQWMDQPNHNPIHPNLRSTVYCSAI-ATGGAEEWDFGWT 784

  Fly   844 LFVNESDASEKSKLMYGLSAIQIPWILQRYIDLAWNEEYVRGQDYFTCLTYISANPVGESLVWDY 908
            :|.|.  |.|..|||..|:..:...:|:||:....:...:|.||..:.:.||::||.|:.|.|::
Zfish   785 MFKNA--AIEADKLMSSLACAKNQTLLKRYLGYTLDPSMIRKQDATSVIVYIASNPDGQKLAWEF 847

  Fly   909 VRENWQRLVDRFGLNERYLGNLIPSITARFSTQTKLEEMEQFFAKYPEAGAG--TAARVRALETV 971
            ||..|:.:...:|:......:||..||..|||:.:||::.:|.:...|.|.|  |||..:|:|..
Zfish   848 VRNKWEYMFTEYGVGSFNFASLISGITKTFSTEAELEQLLKFKSDNSEIGFGSATAALEQAIEKT 912

  Fly   972 KNNIVWLAENLEGVDAWLDKQ 992
            |.||.|:|||.|.:..||..|
Zfish   913 KANIKWVAENQEDITDWLVAQ 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	168/413 (41%)
		M1_APN_2	130..579	CDD:189008	187/479 (39%)
		ERAP1_C	655..969	CDD:288671	102/323 (32%)
LOC100004744	XP_001920418.2	Peptidase_M1	47..450	CDD:279741	168/413 (41%)
		M1_APN_2	57..520	CDD:189008	187/477 (39%)
		ERAP1_C	590..911	CDD:288671	102/324 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6076
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920