DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8630 and SCD5

DIOPT Version :9

Sequence 1:	NP_731781.1	Gene:	CG8630 / 41629	FlyBaseID:	FBgn0038130	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_001032671.2	Gene:	SCD5 / 79966	HGNCID:	21088	Length:	330	Species:	Homo sapiens

Alignment Length:	330	Identity:	156/330 - (47%)
Similarity:	211/330 - (63%)	Gaps:	18/330 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PSAATPSQKVA---KKAEAKT-------------PENKPYELEIVWRNVGLFVILHSMALYGLYL 83
            |..||.:.|:.   .|.|.:.             |..:.....||||||.|..:||..|:|.|.|
Human     2 PGPATDAGKIPFCDAKEEIRAGLESSEGGGGPERPGARGQRQNIVWRNVVLMSLLHLGAVYSLVL 66

  Fly    84 VFAESAYWELLPVYATMFLGGLGITAGVHRLWSHKAYKAKLPLRIFLMLCQSLAFQNSIWEWTRD 148
            : .::....||..|....|..||:|||.||||||::|:|||||||||.:..|:||||.|:||:||
Human    67 I-PKAKPLTLLWAYFCFLLAALGVTAGAHRLWSHRSYRAKLPLRIFLAVANSMAFQNDIFEWSRD 130

  Fly   149 HRVHHKFTDTHADPHNSRRGFFFAHMGWLMCKKHPDVTSKGKQISMEDIEQDPVVMFQKKMYFVV 213
            ||.|||:::|.|||||:||||||:|:|||..:||.||..||:::.:.|:..||||..|:|.|.:.
Human   131 HRAHHKYSETDADPHNARRGFFFSHIGWLFVRKHRDVIEKGRKLDVTDLLADPVVRIQRKYYKIS 195

  Fly   214 MPICCFALPMIFPYYVMGSSLRVCFFTCSMLRFCLSLHFTWLVNSAAHFYGMKPYDVNVSAMNNK 278
            :.:.||.:|.:.|:|:.|.||...:|..|:||:.:||:.:||||||||.||.:|||.::|...|.
Human   196 VVLMCFVVPTLVPWYIWGESLWNSYFLASILRYTISLNISWLVNSAAHMYGNRPYDKHISPRQNP 260

  Fly   279 LVSTLTIGEGWHNYHHVFPWDYKAAELGTYSFNWTTAFIDVMAKIGQAYDLKFVSQEMVYKRVLR 343
            ||:...||||:|||||.||:||.|:|.| .:||.||.|||.|..:|.|.|.|..::.|:..|..|
Human   261 LVALGAIGEGFHNYHHTFPFDYSASEFG-LNFNPTTWFIDFMCWLGLATDRKRATKPMIEARKAR 324

  Fly   344 TGDGS 348
            |||.|
Human   325 TGDSS 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8630	NP_731781.1	Delta9-FADS-like	90..330	CDD:239582	128/239 (54%)
CG8630	NP_731781.1	FA_desaturase	91..297	CDD:278890	110/205 (54%)
SCD5	NP_001032671.2	Delta9-FADS-like	71..311	CDD:239582	128/240 (53%)
		FA_desaturase	77..279	CDD:278890	108/201 (54%)
		Histidine box-1. /evidence=ECO:0000305	94..99		4/4 (100%)
		Histidine box-2. /evidence=ECO:0000305	131..135		2/3 (67%)
		Histidine box-3. /evidence=ECO:0000305	272..276		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154901
Domainoid	1	1.000	46	1.000	Domainoid score	I12114
eggNOG	1	0.900	-	-		E1_COG1398
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63267
OrthoDB	1	1.010	-	-		D296120at33208
OrthoFinder	1	1.000	-	-		FOG0000495
OrthoInspector	1	1.000	-	-		mtm8474
orthoMCL	1	0.900	-	-		OOG6_100468
Panther	1	1.100	-	-	O	PTHR11351
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X207
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.720