DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8630 and SCD

DIOPT Version :9

Sequence 1:	NP_731781.1	Gene:	CG8630 / 41629	FlyBaseID:	FBgn0038130	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_005054.3	Gene:	SCD / 6319	HGNCID:	10571	Length:	359	Species:	Homo sapiens

Alignment Length:	299	Identity:	150/299 - (50%)
Similarity:	206/299 - (68%)	Gaps:	2/299 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KTPENKPYELEIVWRNVGLFVILHSMALYGLYLVFAESAYWELLPVYATMFLGGLGITAGVHRLW 115
            |..|....::|.||||:.|..:||..||||:.|:.....|..|..|: ..|:..||||||.||||
Human    60 KDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVF-YYFVSALGITAGAHRLW 123

  Fly   116 SHKAYKAKLPLRIFLMLCQSLAFQNSIWEWTRDHRVHHKFTDTHADPHNSRRGFFFAHMGWLMCK 180
            ||::|||:||||:||::..::||||.::||.||||.||||::||||||||||||||:|:|||:.:
Human   124 SHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVR 188

  Fly   181 KHPDVTSKGKQISMEDIEQDPVVMFQKKMYFVVMPICCFALPMIFPYYVMGSSLRVCFFTCSMLR 245
            |||.|..||..:.:.|:|.:.:||||::.|...:.:.||.||.:.|:|..|.:.:...|..:.||
Human   189 KHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLR 253

  Fly   246 FCLSLHFTWLVNSAAHFYGMKPYDVNVSAMNNKLVSTLTIGEGWHNYHHVFPWDYKAAELGTYSF 310
            :.:.|:.|||||||||.:|.:|||.|:|...|.|||...:|||:|||||.||:||.|:|. .:..
Human   254 YAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEY-RWHI 317

  Fly   311 NWTTAFIDVMAKIGQAYDLKFVSQEMVYKRVLRTGDGSH 349
            |:||.|||.||.:|.|||.|.||:..:..|:.|||||::
Human   318 NFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNY 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8630	NP_731781.1	Delta9-FADS-like	90..330	CDD:239582	126/239 (53%)
CG8630	NP_731781.1	FA_desaturase	91..297	CDD:278890	107/205 (52%)
SCD	NP_005054.3	Delta9-FADS-like	100..337	CDD:239582	125/238 (53%)
		FA_desaturase	102..306	CDD:278890	108/204 (53%)
		Histidine box-1. /evidence=ECO:0000305	120..125		4/4 (100%)
		Histidine box-2. /evidence=ECO:0000305	157..161		2/3 (67%)
		Histidine box-3. /evidence=ECO:0000305	298..302		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1398
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.837287	Normalized mean entropy	S1208
OMA	1	1.010	-	-		QHG63267
OrthoDB	1	1.010	-	-		D296120at33208
OrthoFinder	1	1.000	-	-		FOG0000495
OrthoInspector	1	1.000	-	-		mtm8474
orthoMCL	1	0.900	-	-		OOG6_100468
Panther	1	1.100	-	-	O	PTHR11351
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X207
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.740