Protein Alignment TBC1D5 and Usp6nl

DIOPT Version :10

• Sequence 1: NP_731780.1
• Gene: TBC1D5 / 41628
• FlyBaseID: FBgn0038129
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_852064.2
• Gene: Usp6nl / 98910
• MGIID: 2138893
• Length: 842
• Species: Mus musculus
• Alignment Length: 770
• Identity: 147/770 - (19%)
• Similarity: 249/770 - (32%)
• Gaps: 279/770 - (36%)

  Fly    21 EHLPGNGAIRVIPEAGAMNSVERYRQ-------EWQVLLENLD--ADPESLRQSAFAG-DLKMSK 75
            |.||.:.|           :.:|.:|       :|..:|:..:  .:.|...:..:.| .|::
Mouse    77 EELPYHNA-----------AADRQKQLEIERTSKWLKMLKKWERYKNTEKFHRRIYKGIPLQL-- 128

  Fly    76 FRSVHWALLLRV--LTSEHRSWTSQRLQQRVRYDKFRADYVRNPHQLAVDCNDDPLSQSTQSVWN 138
             |...|||||.:  :..|.|...| :|:.|.|                 .|:.|
Mouse   129 -RGEVWALLLEIPKMKEETRDLYS-KLKHRAR-----------------GCSPD----------- 163

  Fly   139 QYFSDQDLFAVIRQ---DVVRTFPGVDFFRK--PLVQNAMVNILFYYAREHPYMCYRQGMHEILA 198
                       |||   ||.|||.....||.  .:.|.::.::|..|:..:..:.|.|||.:|.|
Mouse   164 -----------IRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITA 217

  Fly   199 PIIFVVYSDHQSLLHFSELAKTDINPTLLDVLDPAYLEADTYSLFSRLMASVESYYRVSNLVSTP 263
              :.::|.:.:..  |..|.|....|.  ..:...:::.     |.:|:...|.:.::.|
Mouse   218 --LLLMYMNEEDA--FWALVKLFSGPK--HAMHGFFVQG-----FPKLLRFQEHHEKILN----- 266

  Fly   264 GGHIEQRAESPGDNETSTEAEVIGQLNFIRDKILAKQDQHLHHYLQKMEIPLHIFGIRWLRLLFG 328
                                           |.|:|..||    |...||....:.::|....|
Mouse   267 -------------------------------KFLSKLKQH----LDSQEIYTSFYTMKWFFQCF- 295

  Fly   329 REFMLLDL------LLLWDAIFADSDRFDLPNYILVAM-------------------LVHIRDKL 368
                 ||.      |.:||....:.:|      :|.||                   ||....:.
Mouse   296 -----LDRTPFRLNLRIWDIYIFEGER------VLTAMSYTILKLHKKHLMKLSMEELVEFLQET 349

  Fly   369 LLSDYTTSLTYLMRYPNNVDVHLVLRHALFMLNP-KQFEYP-------PNAFTCVSFANS---SA 422
            |..|:.....:::. ...|.:..:.|..|.:..| |:.|||       |....||:..::   |.
Mouse   350 LAKDFFFEDDFVIE-QLQVSMAELKRAKLDLPEPGKEDEYPKKPLGQLPPESACVNHLSNGQRSV 413

  Fly   423 DKDVPPPAGQR----PRTNSENSSMATS------------------------------------- 446
            .:..|..:.:|    ||.|.|:|.:..|
Mouse   414 GRPSPKTSSRREDGSPRKNHEHSPVHHSRNGTPERAGQSRRKSVDEGSKNLKHEAESQRKPSPGM 478

  Fly   447 -----------GSQIDRQIT-----FMQE-RNAADSSALAKLQDTHRVAMDGYLENSPELLRLEL 494
                       .:|....|:     ||.: |..:|:||:.:   |.:.|::|...::...|.:.:
Mouse   479 QDSSRHYNHAAANQNSNAISNVRKEFMPKWRKPSDASAIER---TTKYAVEGKSHSALPALPVAI 540

  Fly   495 K-NAQTVIKIARSKLQSYLSTVRHHVGKQANGSEELGRTLDGIEELCSFLDV------------- 545
            . :|:|.:..:|.|:::    :....||:.:.:.:......|..|..:..:.
Mouse   541 PGSAETRLPNSRQKMKA----LDGGEGKRGSNASQYDNVPGGESEHGASAEEGPERTHPHSPRKH 601

  Fly   546 ------------KFMF----PLHQRSAPIDQALEANEQKQL-NTVSKPPKPTASSTPANAPAALS 593
                        ||.|    |.|.|..|  |..|.:.:... .:.|.||....:| |.:.|.|.|
Mouse   602 PEPSPSPPKVPNKFTFKVQPPSHVRYPP--QLPEEDHRAAYPPSYSNPPVYHGNS-PKHVPTAHS 663

  Fly   594 ATGGYQMPENAFMHSSMRRLLGELREIELSTITSDEKPGNAVVQNGLPAAEPQQR 648
            .....|:.....::.| ||..|.    .||..||.||    ......|...|..|
Mouse   664 GFVSTQISPRPQINPS-RRPYGS----SLSVDTSPEK----AYSRPTPVVLPSSR 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D5	NP_731780.1	TBC	<150..369	CDD:214540	49/248 (20%)
Usp6nl	NP_852064.2	TBC	120..335	CDD:214540	63/320 (20%)
		PTZ00449	<526..>738	CDD:185628	41/200 (21%)