Protein Alignment TBC1D5 and TBC1D5

DIOPT Version :10

• Sequence 1: NP_731780.1
• Gene: TBC1D5 / 41628
• FlyBaseID: FBgn0038129
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_001127853.1
• Gene: TBC1D5 / 9779
• HGNCID: 19166
• Length: 817
• Species: Homo sapiens
• Alignment Length: 737
• Identity: 208/737 - (28%)
• Similarity: 345/737 - (46%)
• Gaps: 138/737 - (18%)

  Fly     5 GIEAI-TLNGSSARESLEHLPGNGAIRVIPEAGAMNSVERYRQEWQVLLENLDADPESLRQSAFA 68
            ||:.: :.:..|..:|.::  |......:...|..||   ||:||:.|..| :....::||....
Human    20 GIDPLSSYSNKSGGDSNKN--GRRTSSTLDSEGTFNS---YRKEWEELFVN-NNYLATIRQKGIN 78

  Fly    69 GDLKMSKFRSVHWALLLRVLTSEHRSWTSQRLQQRVRYDKFRADYVRNPHQLAVDCN---DDPLS 130
            |.|:.|:|||:.|.|.|.||..:...|.|:..:.|..|...:..::.||.::....:   ::|||
Human    79 GQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIKEIHITNPRKVVGQQDLMINNPLS 143

  Fly   131 QSTQSVWNQYFSDQDLFAVIRQDVVRTFPGVDFFRKPLVQNAMVNILFYYAREHPYMCYRQGMHE 195
            |...|:||::|.|::|.::|.|||.||||.:.||::..|:..:.::||.||||:..:.|:|||||
Human   144 QDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHE 208

  Fly   196 ILAPIIFVVYSDHQSLLHFSELAKTDINPTLLDVLDPAYLEADTYSLFSRLMASVESYYRVSNLV 260
            :||||:||::.|||:.||.||.|:.  :..:..||:|.|||.|.|::||:||.:.|.::....
Human   209 LLAPIVFVLHCDHQAFLHASESAQP--SEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFE-- 269

  Fly   261 STPGGHIEQRAES----------PGDNETSTEAEVIGQLNFIRDKILAKQDQHLHHYLQKMEIPL 315
                 |..|:.:.          |.|  ......::.::|.|:|.:|.|.|..|:.:|.::||..
Human   270 -----HDGQKGKETLMTPIPFARPQD--LGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAP 327

  Fly   316 HIFGIRWLRLLFGREFMLLDLLLLWDAIFADSDRFDLPNYILVAMLVHIRDKLLLSDYTTSLTYL 380
            .|:|:||:||||||||.|.|||::|||:|||.....|.:||.||||::|||.|:.|:|.|.|..|
Human   328 QIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLL 392

  Fly   381 MRYPNNVDVHLVLRHALFMLNPKQ------FEYPPN----------------------------- 410
            |.||...|||.::..|||:.:||:      :::.||
Human   393 MHYPFIGDVHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKV 457

  Fly   411 AFTCVSFANSSADKDVPP--PAGQRPRTNSENSSMA-----TSGSQIDRQITFMQERNAADSSAL 468
            :.:.::|........:.|  ..|..|..||.:||..     ||.......:...|::.....|..
Human   458 SNSLINFGRKLISPAMAPGSAGGPVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSES 522

  Fly   469 AKLQDTHRVAMDGY-------LENSPELLRLELKNAQTVIKI---------------ARSKLQSY 511
            ..:|......:.|.       ::...:|..|..||..:...:               :.:|..|:
Human   523 MPVQLNKGDVVTGSDAQVSVPVQTLTDLQGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSF 587

  Fly   512 LSTV---RHH---VGKQANGSEE--------LGRTLDGIEELCSF----LDVKFMFPLHQRSAPI 558
            .|.:   |.|   :|::.  |||        |...|:.::.:|.:    :|...   ::.:...:
Human   588 FSNISRSRSHSKTMGRKE--SEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHL---VNIQDVIL 647

  Fly   559 DQALEANEQ--------KQLNTVSKPPKPTASSTPANAPAALSATGGYQ--MPENAFMHSSMRRL 613
            .:.||..:|        ||:..:.|      .|...| .:.|.|....|  :.:|.:..|...:.
Human   648 QENLEKEDQILVSLAGLKQIKDILK------GSLRFN-QSQLEAEENEQITIADNHYCSSGQGQG 705

  Fly   614 LGELREIELSTI---TSDEKPG 632
            .|:.:.:::|..   .|.|.||
Human   706 RGQGQSVQMSGAIKQASSETPG 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D5	NP_731780.1	TBC	<150..369	CDD:214540	96/228 (42%)
TBC1D5	NP_001127853.1	TBC	79..381	CDD:214540	122/314 (39%)