Protein Alignment TBC1D5 and tbc1d1

DIOPT Version :10

• Sequence 1: NP_731780.1
• Gene: TBC1D5 / 41628
• FlyBaseID: FBgn0038129
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: XP_031751223.1
• Gene: tbc1d1 / 733547
• XenbaseID: XB-GENE-5959648
• Length: 1286
• Species: Xenopus tropicalis
• Alignment Length: 603
• Identity: 111/603 - (18%)
• Similarity: 218/603 - (36%)
• Gaps: 163/603 - (27%)

  Fly    11 LNGSSARESLEHLPGNGAIRVIPEAGAM--NSVERYRQEW------QVLLENLDADPESLRQSAF 67
            |...:.|..||.:..:|.:|   .|.|:  .:.|..|:.|      |:||..::.:.:.|:.|
 Frog   803 LGDIAPRSPLEPVSEDGPVR---SAVAVRHRTTEELRELWKKAILQQILLLRMEKENQKLQAS-- 862

  Fly    68 AGDLKMSKFR-------------SVHWALLL--------RVLTSEHRSWTSQRL--QQRVRYDKF 109
            ..||:..:.:             ::.|..:|        :..|.:..:...|.:  |.|....||
 Frog   863 ENDLQNKRLKLDYEEITPCLKDVTLVWEKMLSTPGRSKIKTDTEKIHAAVGQGVPRQHRGEIWKF 927

  Fly   110 RAD--YVRNPHQLAVDCNDDPLSQSTQSVWNQYFSDQDLFAVIRQDVVRTFPGVDFFRKPL--VQ 170
            .::  .:|:.|.......|.|..:..:.:..|..:       |..|:.||||...:|...|  .|
 Frog   928 LSEQYQLRHQHISKNQLKDTPYKELLKQLTTQQHA-------ILIDLGRTFPTHPYFSAQLGAGQ 985

  Fly   171 NAMVNILFYYAREHPYMCYRQGMHEILAPIIFVVYSDHQSLLHFSELAKTDINPTLLDVLDPAYL 235
            .::.|||..|:...|.:.|.||: ..:|.::         |||.:
 Frog   986 LSLYNILKAYSLLDPEVGYCQGL-SFVAGVL---------LLHMT-------------------- 1020

  Fly   236 EADTYSLFSRLM--ASVESYYRVSNLVSTPGGHIEQRAESPGDNETSTEAEVIGQLNFIR-DKIL 297
            |.|.:.:...||  ..:...||...:..                          |:...: .::|
 Frog  1021 EEDAFKMLKFLMYDLGLRKQYRPDMITL--------------------------QIQMYQLSRLL 1059

  Fly   298 AKQDQHLHHYLQKMEIPLHIFGIRWLRLLFGREFMLLDLLLLWDAIFADSDRFDLPNYILVAMLV 362
            ....:.|:::|:..||...::...|...:|..:|.|..:..::|.||....
 Frog  1060 HDYHRDLYNHLETYEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGS-------------- 1110

  Fly   363 HIRDKLLLSDYTTSLTYLMRYPNNVDVHLVLRHALFMLNPKQFEYPPNAFTCVSFANSSADKDVP 427
            .:..|:.||...:....::::.|...:...:::.|..|...|.|...|....:..:......:|.
 Frog  1111 EVIFKVALSLLGSHKPLILQHENLESIVEFIKNTLPNLGLVQMEKTINQVFEMDISKQLQAYEVE 1175

  Fly   428 PPAGQRPRTNSENSSMATSGSQIDRQITFMQERNAADSSALAKLQDTH-RVAMDGYLENSPELLR 491
            ....|....:|...|.....:::::..:.::::|   ...|.:||.:| |:.:   ||::.|.|:
 Frog  1176 YHVLQDELIDSSPLSDNQRINKLEKANSTLRKQN---FDLLEELQVSHGRIQV---LESTVENLQ 1234

  Fly   492 ---LELKNAQTVIKIARSKLQSYLSTVRHHVGKQANGSEELGRTLDGIEELCSFLDVKFMFPLHQ 553
               ::||.:...:::.||.|.:.:..:|..: |...|:           :||:
 Frog  1235 SNEVKLKRSVLTLELERSALLNTIEELRAQI-KDMQGN-----------KLCN------------ 1275

  Fly   554 RSAPIDQALEANEQKQLN 571
                 ||    ||..|||
 Frog  1276 -----DQ----NEPNQLN 1284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D5	NP_731780.1	TBC	<150..369	CDD:214540	41/223 (18%)
tbc1d1	XP_031751223.1	PTB_TBC1D1_like	166..397	CDD:269967
		DUF3350	805..860	CDD:463365	13/57 (23%)
		TBC	912..1129	CDD:214540	53/293 (18%)
		SMC_prok_B	<1150..>1269	CDD:274008	24/125 (19%)