Protein Alignment TBC1D5 and TBC1D3

DIOPT Version :10

• Sequence 1: NP_731780.1
• Gene: TBC1D5 / 41628
• FlyBaseID: FBgn0038129
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_001116863.3
• Gene: TBC1D3 / 729873
• HGNCID: 19031
• Length: 549
• Species: Homo sapiens
• Alignment Length: 476
• Identity: 93/476 - (19%)
• Similarity: 166/476 - (34%)
• Gaps: 143/476 - (30%)

  Fly    45 RQEWQVLLENLDADPESLRQS------AFAGDLKMSKFRSVHWALLLRVLTSEHRSWTSQRLQQR 103
            :.:|..:|    .|.|..:.|      |:.| :.|: .|...|::||.  |.|      .:|:..
Human    75 KSKWVDML----GDWEKYKSSRKLIDRAYKG-MPMN-IRGPMWSVLLN--TEE------MKLKNP 125

  Fly   104 VRYDKFRADYVRNPHQLAVDCNDDPLSQSTQSVWNQYFSDQDLFAVIRQDVVRTFPGVDFFRK-- 166
            .||...:....|:             |:..|.:      |:|:...:|:.:        |||.
Human   126 GRYQIMKEKGKRS-------------SEHIQRI------DRDVSGTLRKHI--------FFRDRY 163

  Fly   167 PLVQNAMVNILFYYAREHPYMCYRQGMHEILAPIIFVVYSDHQSLLHFSELAKTDINPTLLDVLD 231
            ...|..:::||..|...:|.:.|.:.:..|.|  :|::|..
Human   164 GTKQRELLHILLAYEEYNPEVGYCRDLSHIAA--LFLLYLP------------------------ 202

  Fly   232 PAYLEADTYSLFSRLMA----SVESYYRVSNLVSTPGGHIEQRAESPGDNETSTEAEVIGQLNFI 292
                |.|.:....:|:|    |::.::       :|.|...|..:...::..:|.
Human   203 ----EEDAFWALVQLLASERHSLQGFH-------SPNGGTVQGLQDQQEHVVATS---------- 246

  Fly   293 RDKILAKQDQHLHHYLQKMEI-----PLHIFGIRWLRLLFGREFMLLDLLL-LWDAIFADSDRFD 351
            :.|.:..||        |.::     ||...    :|:|.  :.:.|.|.| |||....:.::..
Human   247 QPKTMGHQD--------KKDLCGQCSPLGCL----IRILI--DGISLGLTLRLWDVYLVEGEQAL 297

  Fly   352 LPNYILVAMLVHIRDKLLLSDYTTSLTYLMRYPNNV------DVHLVLRH---ALFMLNPKQFEY 407
            :|   :..:...::.|.|..  |:......|:.|..      |...||:|   ::..|..|:.:.
Human   298 MP---ITRIAFKVQQKRLTK--TSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKKGDL 357

  Fly   408 PPNAFTCVSFANSSADKDVPPPAGQRPRTNSENSSMATSGSQIDRQITFMQERNAADSSAL---- 468
            ||.|   .....|||.:.||...|.:.....:..:.....::..|.|.......|..||..
Human   358 PPPA---KPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGG 419

  Fly   469 AKLQDTHRVAMDGYLENSPEL 489
            |..:||:.|...|.  .||.|
Human   420 AVREDTYPVGTQGV--PSPAL 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D5	NP_731780.1	TBC	<150..369	CDD:214540	39/230 (17%)
TBC1D3	NP_001116863.3	TBC	99..312	CDD:214540	55/313 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..419		16/71 (23%)
		PHA03381	<356..>468	CDD:177618	22/88 (25%)