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Protein Alignment TBC1D5 and Tbc1d10b

DIOPT Version :10

Sequence 1:	NP_731780.1	Gene:	TBC1D5 / 41628	FlyBaseID:	FBgn0038129	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_653105.3	Gene:	Tbc1d10b / 68449	MGIID:	1915699	Length:	798	Species:	Mus musculus

Alignment Length:	684	Identity:	122/684 - (17%)
Similarity:	219/684 - (32%)	Gaps:	238/684 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ARESLEHLPG----NGAIRVIPEAGAMNSVERYRQEWQVLLENLDADPE----SLRQ-------- 64
            |.::|.:|..    :|.:..:|:.                :.::.:|.|    :||:
Mouse   249 APDTLSYLDSVSLMSGTLESLPDD----------------VSSMGSDSEINGMALRKTDKYGFLG 297

  Fly    65 -SAFAGDLKMS------KFRSVHWALLLRVLTSEHRSWTSQRLQQ-RVRYDK-----FRA---DY 113
             |.::|.|:.|      :.|.:.|..:.    |....|.|:|.|: ::|..|     .||   .|
Mouse   298 GSQYSGSLESSIPVDVARQRELKWLEMF----SNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQY 358

  Fly   114 VRNPHQLAVDCNDDPLSQSTQSVWNQYFSDQDLFAVIRQDVVRTFPGVDFF--RKPLVQNAMVNI 176
            :.|..:| ::.|.....:..::..:..:.|     ||.:|:.|.||..:.|  |....|..:..|
Mouse   359 LSNSKEL-LEQNPGKFEELERAAGDPKWLD-----VIEKDLHRQFPFHEMFAARGGHGQQDLYRI 417

  Fly   177 LFYYAREHPYMCYR--QGMHEILAPIIFVVYSDHQSLLHFSELAKTDINPTLLDVLDPAYLEADT 239
            |      ..|..||  :|..:..||:..|:      |:|.                 ||
Mouse   418 L------KAYTIYRPDEGYCQAQAPVAAVL------LMHM-----------------PA------ 447

  Fly   240 YSLFSRLMASVESYYRVSNLVSTPGGHIEQRAESPGDNETSTEA-EVIGQLNFIRDKILAKQDQH 303
            ...|..|:...:.|.                   ||......|| ::.|::.|   .:|.:....
Mouse   448 EQAFWCLVQICDKYL-------------------PGYYSAGLEAIQLDGEIFF---ALLRRVSPL 490

  Fly   304 LHHYLQKMEIPLHIFGIRWLRLLFGREFMLLDLLLLWDAIFADSDRFDLPNYILVAMLVHIRDKL 368
            .|.:|::..|...::...|...:|.|......:|.:||..|.:.              |.|..::
Mouse   491 AHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEG--------------VKIIFRV 541

  Fly   369 LLSDYTTSLTYLMRYPNNVDVHLVLRHALFMLNPKQFEYPPNAFTCVSFANSSAD-KDVPPPAGQ 432
            .|                    ::|||.|..:...:        :|.....:... :::|....|
Mouse   542 AL--------------------VLLRHTLGSVEKLR--------SCQGMYETMEQLRNLPQQCMQ 578

  Fly   433 RPRTNSENSSMATSGSQIDRQITFMQERNAADSSALAKLQDTHRVAMDGYLENSPELLRLELKNA 497
            ......|.:::..:.:.|:|:       |||.   |.|.::|
Mouse   579 EDFLVHEVTNLPVTEAWIERE-------NAAQ---LKKWRET----------------------- 610

  Fly   498 QTVIKIARSKLQSYLSTVRHHVGKQANGSEELGRTLDGIEELCSFLDVKFMFPLHQRSAPIDQAL 562
                   |.:|| |..:.|.|..:..:  ||..|....:....|.|           |.|   :|
Mouse   611 -------RGELQ-YRPSRRLHGSRAIH--EERRRQQPPLGPSSSLL-----------SLP---SL 651

  Fly   563 EANEQKQLNTVSKPPKPTASSTPANAPAALSATGGYQMPENAFMHSSMRRLLG---------ELR 618
            ::...:.:.....||.|...::....|.|:....|        :|.|:....|         |:|
Mouse   652 KSRGSRAVGGAPSPPPPVRRASAGPVPGAVVIAEG--------LHPSLPSPTGNSTPLGTSKEIR 708

  Fly   619 EIELSTITSDEKPGNAVVQNGLPAAEPQQRHRNE 652
            ..|... ...||......|......|.|::.|.:
Mouse   709 RQEKER-QKQEKDREKERQRQEKERERQEKERQK 741

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.