Protein Alignment TBC1D5 and TBC1D14

DIOPT Version :10

• Sequence 1: NP_731780.1
• Gene: TBC1D5 / 41628
• FlyBaseID: FBgn0038129
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: XP_011511809.1
• Gene: TBC1D14 / 57533
• HGNCID: 29246
• Length: 727
• Species: Homo sapiens
• Alignment Length: 432
• Identity: 80/432 - (18%)
• Similarity: 148/432 - (34%)
• Gaps: 128/432 - (29%)

  Fly    20 LEHLPGNGAIRVIPEAGAMNSVERYRQEWQVLLENLDADPESLRQSAFAGDLKMSKFR---SVHW 81
            ||..|.|...:...||      :::||:::.::  :.|....|:::.........:.|   |:..
Human   316 LEDRPANLPAKPAEEA------QKHRQQYEEMV--VQAKKRELKEAQRRKKQLEERCRVEESIGN 372

  Fly    82 ALLL---RVLTSEHRSWTSQRLQQ--------RVR---YDKFRADYVRNPHQLAVDC------ND 126
            |:|.   .:|.:....|.|::::.        .||   :.....:.:...|:|...|      ..
Human   373 AVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERW 437

  Fly   127 DPLSQSTQSVWNQ--YFSDQDLFA---VIRQDVVRTFPGVDFFRKPLV----------------- 169
            ..||.....|.|:  .||..|..|   :|:.|:.||||.:..|::.|:
Human   438 RSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQVLIFVDFRVGLQKSFQKRKE 502

  Fly   170 -QNAMVNILFYYAREHP-----------YMCYR------QGMHEILAPIIFVVYSDHQSLLHFSE 216
             ::..:..|:.:....|           |.|||      ||| ..:|.::.:......:.:.||.
Human   503 RESTKLQQLWSWCLGGPYHDMLHSILGAYTCYRPDVGYVQGM-SFIAAVLILNLDTADAFIAFSN 566

  Fly   217 LAKTDINPTLLDVLDPAYLEADTYSLFSRLMASVESYYRVSNLVSTPGGHIEQRAESPGDNETST 281
            |..   .|..:     |:...| :.|.....|:.|.::. .||
Human   567 LLN---KPCQM-----AFFRVD-HGLMLTYFAAFEVFFE-ENL---------------------- 599

  Fly   282 EAEVIGQLNFIRDKILAKQDQHLHHYLQKMEIPLHIFGIRWLRLLFGREFMLLDLLL-LWDAIFA 345
                        .|:.|        :.:|..:...|:.|.|:..|:.:. :.|||.. :||....
Human   600 ------------PKLFA--------HFKKNNLTPDIYLIDWIFTLYSKS-LPLDLACRIWDVFCR 643

  Fly   346 DSDRFDLPNYILVAMLVHIRDKLLLSDYTTSLTYLMRYPNNV 387
            |.:.|.....:.:..|  ..|.|...|:.....:|.|.|.::
Human   644 DGEEFLFRTALGILKL--FEDILTKMDFIHMAQFLTRLPEDL 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D5	NP_731780.1	TBC	<150..369	CDD:214540	45/254 (18%)
TBC1D14	XP_011511809.1	ERM_helical	329..>368	CDD:466641	7/46 (15%)
		TBC	398..664	CDD:214540	58/321 (18%)