Protein Alignment TBC1D5 and TBC1D3C

DIOPT Version :10

• Sequence 1: NP_731780.1
• Gene: TBC1D5 / 41628
• FlyBaseID: FBgn0038129
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: XP_006721967.1
• Gene: TBC1D3C / 414060
• HGNCID: 24889
• Length: 610
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 105/529 - (19%)
• Similarity: 180/529 - (34%)
• Gaps: 162/529 - (30%)

  Fly     4 WGIEAITLNGSSARESLEHLPGNGAIRVIP------------EAGAMNSVERYRQEWQVLLENLD 56
            || .|..|....|..|...|||      :|            ||..:......:.:|..:|
Human    90 WG-SAPRLGPLQAPCSSSALPG------LPYSETELPPLTAREAKQIRREISRKSKWVDML---- 143

  Fly    57 ADPESLRQS------AFAGDLKMSKFRSVHWALLLRVLTSEHRSWTSQRLQQRVRYDKFRADYVR 115
            .|.|..:.|      |:.| :.|: .|...|::||.  |.|      .:|:...||...:....|
Human   144 GDWEKYKSSRKLIDRAYKG-MPMN-IRGPMWSVLLN--TEE------MKLKNPGRYQIMKEKGKR 198

  Fly   116 NPHQLAVDCNDDPLSQSTQSVWNQYFSDQDLFAVIRQDVVRTFPGVDFFRK--PLVQNAMVNILF 178
            :             |:..|.:      |:|:...:|:.:        |||.  ...|..:::||.
Human   199 S-------------SEHIQRI------DRDVSGTLRKHI--------FFRDRYGTKQRELLHILL 236

  Fly   179 YYAREHPYMCYRQGMHEILAPIIFVVYSDHQSLLHFSELAKTDINPTLLDVLDPAYLEADTYSLF 243
            .|...:|.:.|.:.:..|.|  :|::|..                            |.|.:...
Human   237 AYEEYNPEVGYCRDLSHIAA--LFLLYLP----------------------------EEDAFWAL 271

  Fly   244 SRLMA----SVESYYRVSNLVSTPGGHIEQRAESPGDNETSTEAEVIGQLNFIRDKILAKQDQHL 304
            .:|:|    |::.::       :|.|...|..:...::..:|.          :.|.:..||
Human   272 VQLLASERHSLQGFH-------SPNGGTVQGLQDQQEHVVATS----------QPKTMGHQD--- 316

  Fly   305 HHYLQKMEI-----PLHIFGIRWLRLLFGREFMLLDLLL-LWDAIFADSDRFDLPNYILVAMLVH 363
                 |.::     ||...    :|:|.  :.:.|.|.| |||....:.::..:|   :..:...
Human   317 -----KKDLCGQCSPLGCL----IRILI--DGISLGLTLRLWDVYLVEGEQALMP---ITRIAFK 367

  Fly   364 IRDKLLLSDYTTSLTYLMRYPNNV------DVHLVLRH---ALFMLNPKQFEYPPNAFTCVSFAN 419
            ::.|.|..  |:......|:.|..      |...||:|   ::..|..|:.:.||.|   .....
Human   368 VQQKRLTK--TSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKKGDLPPPA---KPEQG 427

  Fly   420 SSADKDVPPPAGQRPRTNSENSSMATSGSQIDRQITFMQERNAADSSAL----AKLQDTHRVAMD 480
            |||.:.||...|.:.....:..:.....::..|.|.......|..||..    |..:||:.|...
Human   428 SSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQ 492

  Fly   481 GYLENSPEL 489
            |.  .||.|
Human   493 GV--PSPAL 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D5	NP_731780.1	TBC	<150..369	CDD:214540	39/230 (17%)
TBC1D3C	XP_006721967.1	TBC	160..373	CDD:214540	55/313 (18%)
		PHA03381	<417..>529	CDD:177618	22/88 (25%)