Protein Alignment TBC1D5 and Evi5

DIOPT Version :10

• Sequence 1: NP_731780.1
• Gene: TBC1D5 / 41628
• FlyBaseID: FBgn0038129
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_727526.2
• Gene: Evi5 / 32088
• FlyBaseID: FBgn0262740
• Length: 807
• Species: Drosophila melanogaster
• Alignment Length: 550
• Identity: 102/550 - (18%)
• Similarity: 184/550 - (33%)
• Gaps: 165/550 - (30%)

  Fly   136 VWNQYF----SDQDLFA-----------VIRQDVVRTFPGVDFFRK---PLVQNAMVNILFYYAR 182
            ||.|..    .|:..:|           |||:|:.||:|.|:||::   | .|.|:.|::..|:.
  Fly   125 VWQQLSGASDGDKKQYAEYIKATSACEKVIRRDIARTYPEVEFFKEKDGP-GQEALFNVIKAYSL 188

  Fly   183 EHPYMCYRQGMHEILAPIIFVVYSDHQSLLHFSELAKTDINPTLLDVLDPAYLEADTYSLFSRLM 247
            ....:.|.||...|:.                           ||.:..|   |.:.:::..::|
  Fly   189 HDREVGYCQGSGFIVG---------------------------LLLMQMP---EEEAFAVLVQIM 223

  Fly   248 ASVESYYRVSNLVSTPGGHIEQRAESPGDNETSTEAEVIGQLNFIRDKILAKQDQHLHHYLQKME 312
            ..                |..:....|..:|       :|...:..:.::.:|...:|.:.|:..
  Fly   224 QQ----------------HRMRHMFKPSMSE-------LGLCMYQLENLVQEQIPDMHIHFQQQG 265

  Fly   313 IPLHIFGIRWLRLLF------GREFMLLDLLLLWDAIFADSDRFDLPNYILVAMLVHIRDKLLLS 371
            ....::...|...|:      .....::|:.|        |:..:....:.:|:|:..:|.||..
  Fly   266 FQTTMYASSWFLTLYTTTLNVNLSCRIMDVFL--------SEGMEFIFKVALALLLTGKDTLLCL 322

  Fly   372 DYTTSLTYLMR-YPNNVDVHLV----LRHALFMLNPKQFEYPPNAFTCVSFANSSADKDVPPPAG 431
            |....|.:..: .|..|:..:.    |.::: .||.|:.:.....:       ....|.......
  Fly   323 DMEAMLKFFQKELPGRVEADVEGFFNLAYSI-KLNTKRMKKMEKEY-------QDLKKKEQEEMA 379

  Fly   432 QRPRTNSENSSM--------ATSGSQIDRQITFMQERNAADSSALA---KLQDTHRVAMDGYLEN 485
            :..|...||..:        |.|....||.:.....|...:.::.|   :|....|    .|||.
  Fly   380 ELRRLRRENCLLKQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLRR----SYLEV 440

  Fly   486 SPELLRLELKNAQTVIKIARSKLQSYLSTVRHHVGKQANGSEELGRTLDGIEELCSFLDVKFMFP 550
            |.     :|:||...::....:||      .::|...:|.|.:     ..|:|||...:.
  Fly   441 SH-----QLENANEEVRGLSLRLQ------ENNVSIDSNNSRQ-----SSIDELCMKEEA----- 484

  Fly   551 LHQRSAPIDQALE---------ANEQKQLNTVS------KPPKPTASSTPANAPAALSATGGYQM 600
            |.||...:...||         |..:.|:..:.      :..|.|...|               .
  Fly   485 LKQRDEMVSCLLEELVKVRQGLAESEDQIRNLKAKVEELEEDKKTLRET---------------T 534

  Fly   601 PENAFMHSSMRRLLGELREIELSTITSDEK 630
            |:|:..|.....:..:|||.|.|....|.|
  Fly   535 PDNSVAHLQDELIASKLREAEASLSLKDLK 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D5	NP_731780.1	TBC	<150..369	CDD:214540	38/227 (17%)
Evi5	NP_727526.2	TBC	113..320	CDD:214540	44/256 (17%)
		Smc	<358..>761	CDD:440809	48/253 (19%)