Protein Alignment TBC1D5 and Rabgap1

DIOPT Version :10

• Sequence 1: NP_731780.1
• Gene: TBC1D5 / 41628
• FlyBaseID: FBgn0038129
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_001101311.1
• Gene: Rabgap1 / 311911
• RGDID: 1304691
• Length: 1065
• Species: Rattus norvegicus
• Alignment Length: 662
• Identity: 122/662 - (18%)
• Similarity: 230/662 - (34%)
• Gaps: 210/662 - (31%)

  Fly     7 EAITLNGSSARESLEHLPGNGAIRVIPEAGAMNSVERYRQEWQVLLENLDADPESLRQSAFAGDL 71
            |.:.|...|.||. .....:.::| :|::|:.:|:.....|     ::.:.|.:....|.| ||:
  Rat   469 EVVCLESESERER-RKTTASPSVR-LPQSGSQSSMIPSPPE-----DDEEEDNDEPLLSGF-GDV 525

  Fly    72 K--------------MSKFRSVHWALLLRV----LTSEHRSWTSQRLQQRVRYDKFRADYVRNPH 118
            .              :||     |.|.|.|    |:|..||...:.|:..|             .
  Rat   526 SKECAEKILETWGELLSK-----WHLNLNVRPKQLSSLVRSGVPEALRGEV-------------W 572

  Fly   119 QLAVDC-NDDPLSQSTQSVWNQYFSDQDLFAVIRQDVVRTFPGVDFFRKP--LVQNAMVNILFYY 180
            ||...| |:|.|.:..:.:..:. |.||  :.|.:|:.||||..|:|:..  ..|:::..|...|
  Rat   573 QLLAGCHNNDHLVEKYRILITKE-SPQD--SAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAY 634

  Fly   181 AREHPYMCYRQGMHEILAPIIFVVYSDHQSLLHFSELAKTDINPTLLDVLDPAYLEADTYSLFSR 245
            :.....:.|.|| ...||.::.:...:.|:   ||.|.|...:..|.:             ||.:
  Rat   635 SVYDEEIGYCQG-QSFLAAVLLLHMPEEQA---FSVLVKIMFDYGLRE-------------LFKQ 682

  Fly   246 LMASVE-SYYRVSNLVSTPGGHIEQRAESPGDNETSTEAEVIGQLNFIRDKILAKQDQHLHHYLQ 309
            ....:. .:|::..|:.                            .:|.|         |:::..
  Rat   683 NFEDLHCKFYQLERLMQ----------------------------EYIPD---------LYNHFL 710

  Fly   310 KMEIPLHIFGIRWLRLLFGREFML------LDLLLL--WDAIFADSDRFDLPNYILVAMLVHIRD 366
            .:.:..|::..:|...||..:|.|      :||||.  ...||          .:.:.:|...:|
  Rat   711 DISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIF----------NVALGLLKTSKD 765

  Fly   367 KLLLSDYTTSLTYLMRYPNNVDVHLVLRHALFMLNPKQFEYPPNAFTCVSFANSSADKDVPPPAG 431
            .|||:|:..:|.:..       |.|          ||::....||...:..|
  Rat   766 DLLLTDFEGALKFFR-------VQL----------PKRYRSEENAKRLMELA------------- 800

  Fly   432 QRPRTNSENSSMATSGSQIDRQITFMQERNAADSSALAKLQDTHRVAMDGYLENSPELLRLELKN 496
                .|::.|....  .:.:::...|:|:.|.....:.:.:..:|...:..       :|||.:|
  Rat   801 ----CNTKISQKKL--KKFEKEYHTMREQQAQQEDPIERFERENRRLQEAN-------MRLEQEN 852

  Fly   497 AQTVIKIARSKLQSYLSTVRHHVGKQANGSEELGRTLDGIEELCSFLDVKFMFPLHQRSAPIDQA 561
            .....::..||:                   .|.:.||..||....|:.:.:....:.....|:.
  Rat   853 DDLAHELVTSKI-------------------ALRKDLDNAEEKADALNKELLMTKQKLIDAEDEK 898

  Fly   562 LEANEQK-QLNTVSKPPKPTASSTPANAPAALSATGGYQMPENAFMHSSMRRLLGELREI--ELS 623
            ....|:. ||..:.:.....|.|               ::.:|:       .::|:.::|  :||
  Rat   899 RRLEEESAQLKEMCRRELDKAES---------------EIKKNS-------SIIGDYKQICSQLS 941

  Fly   624 TITSDEKPGNAV 635
            .....::..|.|
  Rat   942 ERLEKQQTANKV 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D5	NP_731780.1	TBC	<150..369	CDD:214540	43/229 (19%)
Rabgap1	NP_001101311.1	PTB_Rab6GAP	141..269	CDD:269922
		DUF3694	303..433	CDD:463599
		TBC	559..768	CDD:214540	56/288 (19%)
		SMC_prok_B	785..>1028	CDD:274008	35/236 (15%)