Protein Alignment TBC1D5 and SGSM1

DIOPT Version :10

• Sequence 1: NP_731780.1
• Gene: TBC1D5 / 41628
• FlyBaseID: FBgn0038129
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_001035037.1
• Gene: SGSM1 / 129049
• HGNCID: 29410
• Length: 1148
• Species: Homo sapiens
• Alignment Length: 393
• Identity: 85/393 - (21%)
• Similarity: 147/393 - (37%)
• Gaps: 93/393 - (23%)

  Fly    33 PEAGAMNSVERYRQEWQVLLENLDADPESLR-QSAFAGDL----KMSKFRSVHWALLLRVLTSEH 92
            |..|:::.    ||..:......:|..|.|. |.:...||    .|.:|.|:..:|.:.:...:.
Human   806 PRDGSVDD----RQSSEATTSQDEAPREELAVQDSLESDLLANESMDEFMSITGSLDMALPEKDD 866

  Fly    93 ---RSWTSQRLQQRVRYDKFRADYVRNPH---------QLAVDCNDDPLSQSTQSVWNQYFSDQ- 144
               ..|.|...::..:.|. ..:....|.         .|||..:.:.:|..:.|  ...:|.:
Human   867 VVMEGWRSSETEKHGQADS-EDNLSEEPEMESLFPALASLAVTTSANEVSPVSSS--GVTYSPEL 928

  Fly   145 -DLFAV----IRQDVVRTFPGVDFFRKPLVQNAMVNILFYYAREHPYMCYRQGMHEILAPIIFVV 204
             ||:.|    |.:||.|......:| .|.....:.||:..|..:|..:.|.|||.::|||
Human   929 LDLYTVNLHRIEKDVQRCDRNYWYF-TPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAP----- 987

  Fly   205 YSDHQSLLHFSELAKTDINPTLLDVLDPAYLEADTYSLFSRLMASVESYYRVSNLVSTPGGHIEQ 269
                                 ||.:||.   ||..:|.|:.||..:...:       ..||.:
Human   988 ---------------------LLVILDD---EALAFSCFTELMKRMNQNF-------PHGGAM-- 1019

  Fly   270 RAESPGDNETSTEAEVIGQLNFIRDKILAKQDQHLHHYLQKMEIPLHIFGIRWLRLLFGREFMLL 334
                  |...:....:|..|:....:::.:...:.|.|          |..||..|.|.||.:..
Human  1020 ------DTHFANMRSLIQILDSELFELMHQNGDYTHFY----------FCYRWFLLDFKRELVYD 1068

  Fly   335 DLLLLWDAIFA----DSDRFDLPNYILVAMLVHIRDKLLLS--DYTTSLTYLMRYPNNVDVHLVL 393
            |:.|:|:.|:|    .|..:.|  :|.:|::...||.:|.:  |:|..:.:........:...||
Human  1069 DVFLVWETIWAAKHVSSAHYVL--FIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVL 1131

  Fly   394 RHA 396
            :.|
Human  1132 KLA 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D5	NP_731780.1	TBC	<150..369	CDD:214540	52/222 (23%)
SGSM1	NP_001035037.1	RUN_SGSM1	20..196	CDD:439065
		PH_RUTBC	254..425	CDD:275431
		Important for interaction with RAB9A and RAB9B. /evidence=ECO:0000250|UniProtKB:Q8BPQ7	256..297
		Required for interaction with RAP family members	301..350
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..411
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	700..830		5/27 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	871..894		3/23 (13%)
		TBC	<936..1105	CDD:214540	52/225 (23%)