Protein Alignment TBC1D5 and TBC1D8

DIOPT Version :10

• Sequence 1: NP_731780.1
• Gene: TBC1D5 / 41628
• FlyBaseID: FBgn0038129
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_001317277.1
• Gene: TBC1D8 / 11138
• HGNCID: 17791
• Length: 1155
• Species: Homo sapiens
• Alignment Length: 635
• Identity: 123/635 - (19%)
• Similarity: 196/635 - (30%)
• Gaps: 232/635 - (36%)

  Fly   150 IRQDVVRTFPGVDFFRKPLVQN-----AMVNILFYYAREHPYMCYRQGMHEILAPIIFVV----- 204
            |.:|:.|:.|     ..|..||     |:..:|..||..:|.:.|.|.|: ||..::.:.
Human   565 IERDLHRSLP-----EHPAFQNETGIAALRRVLTAYAHRNPKIGYCQSMN-ILTSVLLLYTKEEE 623

  Fly   205 ---------------YSDH--------QSLLHFSELAKTDINPTLLDVL-DPAYLEADTYSLFSR 245
                           |.:|        ||:  |.||.|..: |.|.:.: |.:.|.:.:.|.|..
Human   624 AFWLLVAVCERMLPDYFNHRVIGAQVDQSV--FEELIKGHL-PELAEHMNDLSALASVSLSWFLT 685

  Fly   246 LMASVESYYRVSNLV----------------------------STPGG-----------HIEQRA 271
            |..|:.......|:|                            |...|           ||:..
Human   686 LFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEDLCSSKDDGQALMILSRFLDHIKNE- 749

  Fly   272 ESPG------------DNETSTEAEVIGQLNFIRDKILAKQDQ---HLHHYLQKMEIPLHIFGIR 321
            :|||            |.|.....::   .:.|||......||   .:.|...|..|
Human   750 DSPGPPVGSHHAFFSDDQEPYPVTDI---SDLIRDSYEKFGDQSVEQIEHLRYKHRI-------- 803

  Fly   322 WLRLLFGREFMLLDLLLLWDAIFADSDRFDLPNY-ILVAMLVHIRD---------------KLLL 370
              |:|.|.|          |....:..|..:|.. ||...|..:.|               :.:.
Human   804 --RVLQGHE----------DTTKQNVLRVVIPEVSILPEDLEELYDLFKREHMMSCYWEQPRPMA 856

  Fly   371 SDYTTSLTYLMRYPNNVDVHLVLRHALFMLNPKQFEYPPNAFTCVSFANSSADKDVPPPAGQRPR 435
            |.:..|..|..:|  .:|.. ...|...:::|         :||.:.....|::..        |
Human   857 SRHDPSRPYAEQY--RIDAR-QFAHLFQLVSP---------WTCGAHTEILAERTF--------R 901

  Fly   436 TNSENSSMATSGSQIDRQITFMQERNAADSSALAKLQDTHRVAMDGYLENSPELL-RLELKNAQT 499
            ...:|         :|:.|.|....:..|            :..:|.:....:|| ||.:..|.|
Human   902 LLDDN---------MDQLIEFKAFVSCLD------------IMYNGEMNEKIKLLYRLHIPPALT 945

  Fly   500 V-IKIARSKLQS-YLSTVRHHVGKQANGS------------EELGRTLDGIE---------ELCS 541
            . .:.::|.|:: .|||.|..|..:.||.            ::|.:..|..|         |...
Human   946 ENDRDSQSPLRNPLLSTSRPLVFGKPNGDAVDYQKQLKQMIKDLAKEKDKTEKELPKMSQREFIQ 1010

  Fly   542 FLDVKF-MF-------PLHQRSAPIDQALEANEQKQLNTVSKPPKPTAS-----------STPAN 587
            |....: ||       .|:|..|.:...|     .|:..|.:....:.|           |.|:.
Human  1011 FCKTLYSMFHEDPEENDLYQAIATVTTLL-----LQIGEVGQRGSSSGSCSQECGEELRASAPSP 1070

  Fly   588 APAALSATGGYQMPENAFMHSSMRRLLGELREIELSTITSD------EKP 631
            ..:..:.||.......||..::.|.....|..|..|.:|..      |||
Human  1071 EDSVFADTGKTPQDSQAFPEAAERDWTVSLEHILASLLTEQSLVNFFEKP 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D5	NP_731780.1	TBC	<150..369	CDD:214540	63/322 (20%)
TBC1D8	NP_001317277.1	PH-GRAM1_TBC1D8	171..269	CDD:270156
		PH-GRAM2_TBC1D8	311..406	CDD:270160
		TBC	520..726	CDD:214540	35/169 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1046..1085		5/38 (13%)