DRSC/TRiP Functional Genomics Resources

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Protein Alignment TBC1D5 and Tbc1d10a

DIOPT Version :10

Sequence 1:NP_731780.1 Gene:TBC1D5 / 41628 FlyBaseID:FBgn0038129 Length:654 Species:Drosophila melanogaster
Sequence 2:NP_598784.1 Gene:Tbc1d10a / 103724 MGIID:2144164 Length:500 Species:Mus musculus


Alignment Length:366 Identity:75/366 - (20%)
Similarity:114/366 - (31%) Gaps:120/366 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 SSARESLEHLPGNGAIRVIPEAGAMNSVERYRQEWQVLLENLDADPESLRQSAFAGDLKMSKF-- 76
            |..||||    ..|     |:|...:.           |.:|.:|.|:   :.|| :.::.||  
Mouse    20 SGTRESL----AQG-----PDAATADE-----------LSSLGSDSEA---NGFA-ERRIDKFGF 60

  Fly    77 ----RSVHWAL---LLRVLTSEHRSWTSQRLQQRVRYDKFRADYVRNPHQLAVDCNDDPLSQSTQ 134
                :....||   .|.||......|    |.....:||:.|   :...::.:.|..........
Mouse    61 IVGSQGAEGALEEVPLEVLRQRESKW----LDMLNNWDKWMA---KKHKKIRLRCQKGIPPSLRG 118

  Fly   135 SVWNQYFS---------------------DQDLFAVIRQDVVRTFPGVDFF--RKPLVQNAMVNI 176
            ..| ||.|                     |.....||.:|:.|.||..:.|  |....|..:..:
Mouse   119 RAW-QYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRV 182

  Fly   177 LFYYAREHPYMCYRQGMHEILAPIIFVVYSDHQSLLHFSELAKTDINPTLLDVLDPAYLEADTYS 241
            |..|....|    .:|..:..|||..|:      |:|.                 ||      ..
Mouse   183 LKAYTLYRP----EEGYCQAQAPIAAVL------LMHM-----------------PA------EQ 214

  Fly   242 LFSRLMASVESYYRVSNLVSTPGGHIEQRAESPGDNETSTEA-EVIGQLNFIRDKILAKQDQHLH 305
            .|..|:...|.|.                   ||......|| ::.|::.|   .:|.|.....|
Mouse   215 AFWCLVQVCEKYL-------------------PGYYSEKLEAIQLDGEILF---SLLQKVSPVAH 257

  Fly   306 HYLQKMEIPLHIFGIRWLRLLFGREFMLLDLLLLWDAIFAD 346
            .:|.:.:|...::...|....|.|......:|.:||..|.:
Mouse   258 KHLSRQKIDPLLYMTEWFMCAFARTLPWSSVLRVWDMFFCE 298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBC1D5NP_731780.1 TBC <150..369 CDD:214540 42/200 (21%)
Tbc1d10aNP_598784.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..45 10/44 (23%)
TBC 110..313 CDD:214540 48/245 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 396..415
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..500
Binding to the PDZ domain of EBP50. /evidence=ECO:0000250 497..500
Blue background indicates that the domain is not in the aligned region.

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