Protein Alignment Ace and Ache

DIOPT Version :10

• Sequence 1: NP_476953.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_038945765.1
• Gene: Ache / 83817
• RGDID: 69313
• Length: 616
• Species: Rattus norvegicus
• Alignment Length: 649
• Identity: 239/649 - (36%)
• Similarity: 341/649 - (52%)
• Gaps: 67/649 - (10%)

  Fly    12 PMSLPLPLTIPLPLVLVLSLHLSGVCGVIDR----LVVQTSSGPVRGRSVTVQGREVHVYTGIPY 72
            |:..| .|..|| |.|:||| |.|......|    |:|:...|.:||..:...|..|..:.|||:
  Rat     7 PLHTP-SLASPL-LFLLLSL-LGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPF 68

  Fly    73 AKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVW 137
            |:|||...||..|.|..||.|:||||.....|.|.....:|||.|.|:||||..:||||||:|||
  Rat    69 AEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVW 133

  Fly   138 APAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNA 202
            .|               :|                 ..|:..|:|||||||||.:|:::||:|:.
  Rat   134 TP---------------YP-----------------RPTSPTPVLIWIYGGGFYSGASSLDVYDG 166

  Fly   203 DIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNP 267
            ..:|.|...::.|..||||.||||.|    |.  :.:|||||||.||.||::|:::|..||||:|
  Rat   167 RFLAQVEGTVLVSMNYRVGTFGFLAL----PG--SRDAPGNVGLLDQRLALQWVQENIAAFGGDP 225

  Fly   268 EWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNA 332
            ..:||||||||::||...::|..:|.|..|.::||||.|.||:.:::.:|......|.....|..
  Rat   226 MSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPP 290

  Fly   333 SMLKTNPAHVMSCMRSVDAKTISVQQWN--SYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDY 395
            .....|...::||:|:..|:.:...:|:  ....|..|...|.:||.||...|..|:.|.|.:|.
  Rat   291 GGAGGNDTELISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDL 355

  Fly   396 DILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSW--E 458
            .:|:|.|:|||:|||:|. :..|.||:.:.:.|.::|..:.....:|:....||::..||.|  .
  Rat   356 QVLVGVVKDEGSYFLVYG-VPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHP 419

  Fly   459 GNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLHGDEIE 523
            .:|.:. :..:...||||...||..:.|..||.:||.|:.|.|.||.||..|..||||.||.|||
  Rat   420 EDPAHL-RDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIE 483

  Fly   524 YFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNP--AQDGE--EWPNFSKEDPVYYIFSTDD 584
            :.||.||:.||.|...||...:|::.....||:||:|  .:|.:  .||.::.....|  .|.:.
  Rat   484 FIFGLPLDPSLNYTVEERIFAQRLMKYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQY--VSLNL 546

  Fly   585 KIEKLARGPLAARCSFWNDYLPKVRSWAG-----TCDGDS-GSASISP----RLQLLGIAALIY 638
            |..::.||..|..|:|||.:|||:.|...     ||...: |.|:..|    .|.||....|::
  Rat   547 KPLEVRRGLRAQTCAFWNRFLPKLLSATATEVPCTCPSPAHGEAAPRPGPALSLSLLFFLFLLH 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_476953.1	COesterase	43..601	CDD:395084	210/565 (37%)
Ache	XP_038945765.1	COesterase	37..563	CDD:395084	210/567 (37%)