DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Ces2g

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_932116.2	Gene:	Ces2g / 72361	MGIID:	1919611	Length:	560	Species:	Mus musculus

Alignment Length:	598	Identity:	169/598 - (28%)
Similarity:	268/598 - (44%)	Gaps:	85/598 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGRE--VHVYTGIPYAKPPVEDLRFRKPVPA 88
            :|:|..|:.|........:..|.||.|:||.:.|:..:  ||.:.|||:|||||..|||..|...
Mouse    17 LLLLLGHVQGHDSPETSPIRSTHSGQVQGRLIHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAP 81

  Fly    89 EPWHGVLDATRLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGG 153
            |||.||.|.|...|.|.|.......|....::..|..::||||||:|::.||.|:    .|:|
Mouse    82 EPWSGVRDGTSQPAICPQNVTMNMEGLKELKLTLPPVSMSEDCLYLNIYTPAHAQ----EGSN-- 140

  Fly   154 EHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQY 218
                                     ||:::||:||....|.|::  |:..::||..:|:|.:.||
Mouse   141 -------------------------LPVMVWIHGGALTVGMASM--YDGSVLAATEDVVVVAIQY 178

  Fly   219 RVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVN 283
            |:|..||.       |...|.|.||.|..||..|:||::.|...|||||:.:|:||||||..||:
Mouse   179 RLGVLGFF-------STGDEHARGNWGFLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGISVS 236

  Fly   284 AQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRS 348
            :.::||:::||..|.:|:||....|.:..:..:.|....|.::.|....|      ..::.|:|.
Mouse   237 SHVVSPMSKGLFHRAIMESGVALLPGTIFSFSEVVYQTVAKLSGCEAMDS------EALVRCLRG 295

  Fly   349 VDAKTISVQQWNSYSGILSFPSAP-TIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFL-- 410
            ...:.|.....|       |...| .:||.|||..|..|:.:||......::|...||..:.:
Mouse   296 KSEEEILAISKN-------FQMIPGVVDGEFLPKHPQELLASADFHPVPSIIGFNNDEYGWIVPK 353

  Fly   411 ---LYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRA 472
               ....|....:::..|:.:|...::|       ...|...::.:....:.......|.|....
Mouse   354 VIGSTQTIKGITRENLQAVLKDTAPQMM-------LPPECSDLLMEEYMEDIEDPKTLQIQFTEM 411

  Fly   473 VGDHFFTCPTNEYAQALAERGASVHYYYFTHRTS--TSLWGEWMGVLHGDEI-----EYFFGQPL 530
            :.|..|..|:.:.|. .....|.|::|.|.|::|  ..:....:...||||:     .:|:|..|
Mouse   412 MEDFMFVIPSLQVAY-FQRSHAPVYFYEFQHQSSFLKDVRPPHVNADHGDEVPFVFGSFFWGMKL 475

  Fly   531 NNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDG-EEWPNFSKEDPVYYIFSTDDKIEKLARGPL 594
            |.:.:    |:.|.:||:.....||:.|||..:. ..||.|. .|..|...:....:.:..:
Mouse   476 NLTEE----EKLLNRRMMKYWANFARHGNPNSESLPYWPVFD-HDEQYLQLNIQPAVGQFQK--- 532

  Fly   595 AARCSFWNDYLPK 607
            |.:..||...||:
Mouse   533 ARKLQFWTKTLPR 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	161/575 (28%)
Ces2g	NP_932116.2	COesterase	31..539	CDD:278561	161/576 (28%)
Ces2g	NP_932116.2	Aes	72..>337	CDD:223730	101/317 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810