DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Ces2j

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_038953911.1	Gene:	Ces2j / 685645	RGDID:	1591368	Length:	576	Species:	Rattus norvegicus

Alignment Length:	596	Identity:	171/596 - (28%)
Similarity:	260/596 - (43%)	Gaps:	110/596 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 TSSGPVRGRSVTVQGRE--VHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQERY 109
            |.:|.|||..|.|:..:  :|.:.|||:|||||..|||..|...|||.||.|||...|.|:|...
  Rat    56 THTGQVRGSFVHVKDTKSGIHTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTAM 120

  Fly   110 EYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQN 174
            ....|....|:  ....:||||||:|::.||.|                               :
  Rat   121 MNLEGMKETEL--TKLPMSEDCLYLNIYVPAHA-------------------------------H 152

  Fly   175 TTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEE 239
            ..:.||:::||:|||.:.|||:::  :|..:||...:::.|.|||:|..||.       |...:.
  Rat   153 EDSNLPVMVWIHGGGLVGGSASMN--DASTLAATEEIVIVSIQYRLGVLGFF-------STGDQH 208

  Fly   240 APGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGT 304
            |.||.|..||..|:||::.|...||||.:.:|:||.|||.:||::.::||:::||..|.:||||.
  Rat   209 ARGNWGYLDQMAALRWVQQNIAYFGGNRDSVTIFGVSAGGTSVSSHVVSPMSKGLFHRAIMQSGV 273

  Fly   305 MNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTISV--QQWNSYSGILS 367
            ...|  .:.|:.:..:.|.:.|...|.||    :...::.|:|:...:.|..  |.:....|:
  Rat   274 ALLP--GLISDTSEVVYKTVANLSGCEAS----DSEALIRCLRAKSKQEILAINQVFKMIPGV-- 330

  Fly   368 FPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDE-----GTYFLLYDFIDYFDKDDATA-- 425
                  :||.|||..|..|:.:.|......::|...||     .|...||..|:...::...|
  Rat   331 ------VDGKFLPKHPQELLASKDFHPVPSIIGVNTDECGWGVPTILGLYHIINNITRETLPAAL 389

  Fly   426 --------LPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPT 482
                    ||.:....||....|....||                 ..|.|....:||..|..|.
  Rat   390 KIAAAQMMLPPECIDLIMEEYMGDTEDAE-----------------TLQAQFKEMLGDFIFVIPA 437

  Fly   483 NEYAQALAERGASVHYYYFTHRTS--TSLWGEWMGVLHGDEI-----EYFFGQPLNNSLQYRPVE 540
            .:.|. .....|.|::|.|.|..|  ..:...:....|||:.     .||:|...:.:.:    |
  Rat   438 LQVAH-FQRSQAPVYFYEFQHLLSFIKQVRPFYPKADHGDDTVFVFGSYFWGMTFDLTEE----E 497

  Fly   541 RELGKRMLSAVIEFAKTGNP-AQDGEEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDY 604
            ..|.:|::.....||:|||| .:|...||....::....:.|.    ..:.|...|.|..||...
  Rat   498 ELLKRRVMKYWANFARTGNPNGEDLPHWPVLDHDEQYLQLNSQ----PAVGRALKARRLQFWTKT 558

  Fly   605 LP-KVRSWAGT 614
            || |::...|:
  Rat   559 LPQKIQELKGS 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	165/580 (28%)
Ces2j	XP_038953911.1	COesterase	50..555	CDD:395084	165/580 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810